Long-term influence of bone marrow-derived mesenchymal stem cells on liver ischemia-reperfusion injury in a rat model.
Conclusions These results suggest that intraportal bone marrow-derived mesenchymal stem cell injection is safe and cells do not migrate chaotically to other organs after targeted implementation. PMID: 25754665 [PubMed - in process]
We report a series of 5 solid organ transplantation recipients diagnosed with STEC-HUS between January 2017 and March 2019 in 2 French nephrology centers (Table 1). One patient had 2 episodes of STEC-HUS. All had severe acute kidney injury (requiring hemodialysis in 2). Neurological involvement was noted during 5 episodes: seizures (n = 4) and confusion/coma (n = 4).
As many as 10% to 20% of patients undergoing kidney transplantation develop post-transplant diabetes mellitus, which is associated with increased mortality. Even borderline changes in glucose metabolism, so-called prediabetes, may involve a similar risk. A recent study by Porrini et al. showed for the first time that such changes in glucose metabolism are in fact associated with future cardiovascular disease and death in kidney-transplanted patients. This commentary discusses the relevance and clinical implications of these new findings.
Kidney and urinary tract congenital anomalies are present in 9.5% of males under age 18. A donor in his 50s had head trauma and was found to have a horseshoe kidney. En bloc organ donation was performed after circulatory death with 41 minutes of warm ischemia time. The kidney donor profile index was 73%, final creatinine was 0.7 mg/dl, and kidney biopsies revealed 2% (right) and 3% (left) glomerulosclerosis with no fibrosis, arteriosclerosis, or arteriolosclerosis. Both kidneys had anteriorly positioned ureters, separated by a 2-cm isthmus (Figure 1).
A 48-year-old kidney transplant recipient was admitted to our hospital with nausea, polyuria, diffuse paresthesia, and muscle weakness of all extremities. His past medical history was remarkable for renal transplantation with impaired graft function (baseline glomerular filtration rate approximately 20 ml/min per 1.73 m2) and parathyroidectomy due to an uncontrolled hyperparathyroidism. An electrocardiogram showed pronounced concave ST-segment elevations in leads II, III, and aVF suspicious of an acute ST elevation myocardial infarction as well as ascending elevations deriving from a deep S wave especially in leads V1 &nda...
Conditions: Osteoporosis, Osteopenia; Renal Transplant Recipient Interventions: Drug: Denosumab 60 mg/ml [Prolia]; Drug: Alendronate 70Mg Tab Sponsors: Ain Shams University; Nahda University Recruiting
Kidney transplants between monozygotic twins can be done successfully without immunosuppression, with excellent outcomes, shows an analysis of twin transplants in the modern era.Medscape Medical News
In this study, we evaluated which cumulative dose of rATG was most appropriate for transplantation in NHPs. Cynomolgus monkeys were treated with intravenous 5 mg/kg rATG (Thymoglobulin®, Genzyme Ltd., UK) twice, on days 0 and 2 (a total of 10 mg/kg, n=2), or 4 times, on days 0, 1, 2, and 3 (a total of 20 mg/kg, n=6). In addition, we performed allo-KT in cynomolgus monkeys (n=4) with a cumulative 20 mg/kg dose of rATG with optimized dosing for induction therapy. We further compared immune cells, including naïve, central memory, and effector memory T cells, in reconstituted distributions in human KT patients (n=22)....
AbstractCostimulation between T cells and antigen-presenting cells is essential for the regulation of an effective alloimmune response and is not targeted with the conventional immunosuppressive therapy after kidney transplantation. Costimulation blockade therapy with biologicals allows precise targeting of the immune response but without non-immune adverse events. Multiple costimulation blockade approaches have been developed that inhibit the alloimmune response in kidney transplant recipients with varying degrees of success. Belatacept, an immunosuppressive drug that selectively targets the CD28-CD80/CD86 pathway, is the...
CONCLUSIONS: Anesthetic preconditioning is a promising strategy to prevent I-R injury associated with transplantation. Our results suggest that sirtuin 2 is involved in the protective mechanisms of some commonly used anesthetics against I-R damage. PMID: 31726818 [PubMed - as supplied by publisher]
(University of Illinois at Chicago) Researchers report that among patients with obesity, robotic kidney transplants produce survival outcomes comparable to those seen among nonobese patients. The study includes data collected over 10 years from more than 230 robotic-assisted kidney transplants in patients with obesity.