Noradrenergic α2 receptor attenuated inflammatory pain through STEP61/ERK signalling

ConclusionThe analgesic action produced by noradrenergic α2 receptor agonist clonidine involved the reversal of ERK1/2 hyperactivity in spinal dorsal horn of inflamed mice.
Source: European Journal of Pain - Category: Anesthesiology Authors: Tags: Original Article Source Type: research

Related Links:

Conclusion, do not visit cardiologists. They will give you heart attacks. No, that’s ridiculous. It’s so mind blowing that anyone even said this, right? It’s just ugh. Obviously, people who are extremely sick and who are at risk of killing themselves get psychiatric care. No kidding. So, yeah, this is, in fact, very dangerous. Gabe: The word bullshit is not big enough. This is the literal equivalent of me saying that I looked at fifty thousand people who went to the hospital in the last year. And you were much more likely to die if you had a hospital admission. Now, I’m talking physical health now. ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: General Mental Health and Wellness Not Crazy Podcast Psychiatry Treatment Source Type: blogs
In this study, we used the withdrawal symptoms precipitated by naloxone to characterize opioid dependence in mice. We determined the functional role of mu-opioid receptors (MORs) expressed in different subpopulations of neurons in the development of morphine withdrawal. We found that conditional deletion of MORs from glutamatergic neurons expressing vesicular glutamate transporter 2 (Vglut2+) largely eliminated the naloxone-precipitated withdrawal symptoms. In contrast, conditional deletion of MORs expressed in GABAergic neurons had a limited effect on morphine withdrawal. Consistently, mice with MORs deleted from Vglut2+ ...
Source: Neuroscience Bulletin - Category: Neuroscience Source Type: research
Another term is being added to the lexicon in the midst of the COVID-19 pandemic: quarantine brain. It takes many forms, from confusion and fogginess to limited executive functioning. Those who fall prey to it may find themselves unable to complete tasks, manage their time and routine, and make sound decisions. This occurs even if the person has no prior history with attention deficit disorder/attention deficit hyperactivity disorder. Some report a lack of motivation to get out of bed, let alone engage in their daily activities. What helps them is knowing that their boss, teachers, and family are counting on them to launch...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Dreams Memory and Perception Personal Coping Skills coronavirus COVID-19 pandemic Resilience social distancing Source Type: blogs
Conclusions: Kratom use may serve as a self-treatment strategy for a diverse population of patients with pre-existing health diagnoses. Healthcare providers need to be engaging with patients to address safety concerns and potential limitations of its use in clinical practice for specific health conditions.
Source: Journal of Addiction Medicine - Category: Addiction Tags: Original Research Source Type: research
Discussion Fragile X syndrome (FXS) was first clinically described in 1943 by Martin-Bell and in 1969 Lubs found a fragility at the terminal end of the X chromosome. In 1991, three different research groups independently cloned the mutation for the FMR1 gene (Fragile X mental retardation type 1) which has a CGG triplet expansion. The FMR1 gene codes for the FMR protein which is a major regulator of synaptic plasticity and is expressed in the brain and spermatogonia mainly but many other tissues during fetal and early neonatal development. The number of triplets and methylation correlates with clinical expression (increased...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Traumatic/contusive spinal injury produces all or most of the following disruptions of spinal cord integrity: tearing of the meninges with leakage of cerebral spinal fluid (CSF); disruption of the blood –spinal cord barrier; vertebral scarring with eventual tethering/compression of the cord; inflammation; vascular disruption with hemorrhage, edema and ischemia; free-radical injury with neuronal excitotoxicity, at-level neuronal hyperactivity, apoptosis and eventual cellular loss; mitochondrial dy sfunction; electrolytic changes; accumulation or loss of transmitters; up- and down-regulation of transmitter receptors; d...
Source: The Journal of Pain - Category: Materials Science Authors: Tags: Review Article Source Type: research
Rationale: Pain management is an essential part of good obstetrical care. The rapid onset of pain relief after combined spinal-epidural (CSE) analgesia may cause a transient imbalance in maternal catecholamine level, leading to uterine hyperactivity and fetal heart rate (FHR) abnormalities. How to manage the uterine basal tone and FHR abnormalities after labor analgesia still remains controversial. Patient concerns: A 33-year-old nulliparous woman at 40+5 weeks’ gestation underwent induction of labor after premature rupture of membranes. CSE analgesia was provided when the patient described her pain as the top o...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
Abstract Background: Pulsed radiofrequency (PRF) on the dorsal root ganglion (DRG) has been applied to alleviate neuropathic pain effectively, yet the mechanisms underlying pain reduction owing to this treatment are not clarified completely. The activated microglia, brain-derived neurotrophic factor (BDNF), phosphatidylinositol 3-kinase (PI3K), and phosphorylated extracellular signal-regulated kinase (p-ERK) in the spinal cord were demonstrated to be involved in developing neuropathic pain. Also, it has been just known that PRF on DRG inhibits the microglial activation in nerve injury rats. Here, we aim to investi...
Source: Pain Research and Management - Category: Anesthesiology Authors: Tags: Pain Res Manag Source Type: research
Discussion Restless legs syndrome (RLS) is also known as Willis-Ekbom disease. RLS is a clinical diagnosis with criteria being: 1. An urge to move the legs usually accompanied by uncomfortable and unpleasant sensations in the lower extremities (Note: sometimes other body parts can be affected) 2. The urge to move begins or worsens when sitting or lying down 3. The urge to move is partially or totally relieved by movement (Note: relief by activity may not be noticable if severely affected but must have been previously present) 4. The urge to move the legs and any accompanying unpleasant sensations during rest or in activ...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Back pain in children is a complex phenomenon, which has been shown to be associated with physical and psychosocial factors. None of the studies on Indian children have investigated the possible association between back pain and psychosocial factors. We decided to determine the prevalence of back pain in students and association with both physical and psychosocial factors. A cross-sectional study was conducted on 163 students from two city schools. Physical factors were evaluated using a structured questionnaire. Strengths and difficulties questionnaire was used to assess psychosocial factors. The studied sample consisted ...
Source: Journal of Pediatric Orthopaedics B - Category: Orthopaedics Tags: SPINE Source Type: research
More News: Anesthesiology | Back Pain | Clonidine | Hyperactivity | Pain | Study