The brighter (and evolutionarily older) face of the metabolic syndrome: evidence from Trypanosoma Cruzi infection in CD‐1 mice

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Source: Diabetes/Metabolism Research and Reviews - Category: Endocrinology Authors: Tags: Research Article Source Type: research

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Publication date: Available online 15 February 2019Source: Biochimica et Biophysica Acta (BBA) - Molecular Basis of DiseaseAuthor(s): Aline R. Lorenzon-Ojea, Hong Wa Yung, Graham J. Burton, Estela BevilacquaAbstractEndoplasmic reticulum (ER) stress occurs when the protein folding machinery in the cell is unable to cope with newly synthesized proteins, which results in an accumulation of misfolded proteins in the ER lumen. In response, the cell activates a cellular signaling pathway known as the Unfolded Protein Response (UPR), aiming to restore cellular homeostasis. Activation and exacerbation of the UPR have been describe...
Source: Biochimica et Biophysica Acta (BBA) Molecular Basis of Disease - Category: Molecular Biology Source Type: research
TYPE 2 diabetes can be controlled by eating the right kind of diet, but this can be difficult when balancing a busy schedule and eating on the go. There is one simple and tasty lunch which can fill you up and stop you from snacking on unhealthy foods while preventing blood sugar spikes.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Publication date: Available online 15 February 2019Source: Chemico-Biological InteractionsAuthor(s): Saniyya Khan, Syeedul Hasan Arif, Imrana NaseemAbstractRiboflavin (Rf) or vitamin B₂ is a known photosensitizer whose photophysical and photochemical properties are well established. Aminophylline (Am) is a phosphodiesterase inhibitor and is currently used as a bronchodilator. Although there are several reports of haemolytic and proteolytic interaction of photoilluminated riboflavin with aminophylline, the cytotoxicity of this system against malignant tissue is not well defined and fully unravelled. Here, we are evaluatin...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
Publication date: January–February 2019Source: Mendeleev Communications, Volume 29, Issue 1Author(s): Vera V. Musiyak, Dmitry A. Gruzdev, Marionella A. Kravchenko, Diana V. Vakhrusheva, Galina L. Levit, Victor P. Krasnov, Valery N. CharushinNovel purin-6-yl, 2-aminopurin-6-yl and N-(purin-6-yl)glycyl derivatives of (S)-lysine and (S)-ornithine with free α-functional groups, as well as compounds containing N9-(2-hydroxy-ethoxy)methyl substituent in the purine core have been synthesized and tested for their inhibitory effect against Mycobacterium tuberculosis strains. Among the synthesized conjugates, one compoun...
Source: Mendeleev Communications - Category: Chemistry Source Type: research
In this study, CaCo2 colorectal adenocarcinoma cells were initially epigenetically reprogrammed and transformed into CD4+ cells with nano-sized complexes of amphiphilic poly-(N-vinylpyrrolidone) (PVP) with miRNA-152 and piRNA-30074. The transformation of cells was confirmed by morphological and genetic changes in the dynamic of reprogramming. CD4+ lymphocytes marker was detected using immunofluorescence. Amphiphilic poly-(N-vinylpyrrolidone)/small non-coding RNAs complexes were investigated for transfection efficiency and duration of transfection of CaCo2 colorectal adenocarcinoma cells using fluorescence.Graphical abstract
Source: Toxicology Reports - Category: Toxicology Source Type: research
Publication date: Available online 16 February 2019Source: Clinical Epidemiology and Global HealthAuthor(s): Rashid Said Saif Almamari, Eilean Rathinasamy Lazarus, Joshua Kanaabi Muliira
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
Conclusions Developed by physicians with input from patients and other involved health-care providers such as nurses, this relatively novel concept of a patient’s checklist creates a role for the patient to ensure their own safety. With increasing attention to high-quality and cost-effective health care, patient satisfaction surveys will be assessed to rate overall health care. Further development of checklists will need to be guided by specific medical conditions and acceptance by patients and providers. Providers can use these checklists as a method to gauge a patient’s understanding of an intervention, sol...
Source: Journal of Patient Safety - Category: Health Management Tags: Original Articles Source Type: research
This paper surveys a group of natural hazards such as droughts, earthquakes, epidemics, locusts, transient weather events, and volcanos, conceiving of all of them as belonging to a broader category of short-term cataclysmic events (SCEs). Although the even...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Disaster Preparedness Source Type: news
INTRODUCTION: Hippotherapy has recently emerged as a horse-based rehabilitative therapy to improve balance, coordination, and strength in patients with a wide range of medical conditions. Although several studies have demonstrated its effectiveness in rest...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Economics of Injury and Safety, PTSD, Injury Outcomes Source Type: news
BACKGROUND: The excess of mortality in people with severe mental illness is due to unnatural causes such as accidents or suicides and natural causes such as metabolic syndrome. The presence of modifiable risk factors like tobacco consumption increases card...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
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