Group A Strep (GAS) Infection

Group A Strep (GAS)
Source: eMedicineHealth.com - Category: Journals (General) Source Type: news

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In this study, we generated an isogenic serotype M1 GAS mutant deficient in Cas9 protein and compared its behavior and phenotypes to the wild-type parent strain. Absence of Cas9 was linked to reduced GAS epithelial cell adherence, reduced growth in human whole blood ex vivo, and attenuation of virulence in a murine necrotizing skin infection model. Virulence defects of the GAS ∆cas9 strain were explored through quantitative proteomic analysis, revealing a significant reduction in the abundance of key GAS virulence determinants. Similarly, deletion of cas9 affected the expression of several known virulence regulatory prot...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
ConclusionsPatients with NSTI were heterogeneous regarding co-morbidities, initial symptoms, infectious localisation, and microbiological findings. Higher age and lactate levels were associated with increased mortality, and GAS infection with decreased mortality.
Source: Intensive Care Medicine - Category: Intensive Care Source Type: research
Alecia Kennen, 37, of Rice Lake, Wisconsin, developed toxic shock syndrome after a rug burn on her shoulder in June 2015 was infected with group A Streptococcus bacteria.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
ARIES Group A Strep Assay , REF 50-10041, UDI # 00840487101469
Source: Medical Device Recalls - Category: Medical Devices Source Type: alerts
This commentary highlights the article by Bernard et al that reports the role of rocA polymorphisms in the pathogenesis of Group A Streptococcus.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Commentary Source Type: research
This commentary highlights the article by Bernard et  al that reports the role of rocA polymorphisms in the pathogenesis of Group A Streptococcus.
Source: American Journal of Pathology - Category: Pathology Authors: Tags: Commentary Source Type: research
Abstract This commentary highlights the article by Bernard et al that reports the role of rocA polymorphisms in the pathogenesis of Group A Streptococcus. PMID: 31421073 [PubMed - as supplied by publisher]
Source: The American Journal of Pathology - Category: Pathology Authors: Tags: Am J Pathol Source Type: research
Streptococcus pyogenes or group A streptococcus (GAS) can cause several mild to life-threatening infections. Age, intravenous drug use, problematic alcohol use, immunosuppression and presence of chronic disease (diabetes mellitus, cancer, or HIV) are the main risk factors for invasive disease among adults.1 GAS infections are defined as invasive (iGAS) based on isolation of the pathogen from blood or other sterile sites. Globally, the occurrence of iGAS has increased during the last decade with an estimate incidence from 2 to 4 per 100,000 in developed countries.
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Condition:   Attention Deficit-Hyperactivity Disorder Interventions:   Diagnostic Test: Antistreptolysin O Test;   Diagnostic Test: Anti-Deoxyribonuclease B;   Diagnostic Test: TLR, MyD88, IRAK-4 polymorphism Sponsor:   University of Turin, Italy Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
ACS Medicinal Chemistry LettersDOI: 10.1021/acsmedchemlett.9b00239
Source: ACS Medicinal Chemistry Letters - Category: Chemistry Authors: Source Type: research
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