Modeling drug resistance in a conjoint normal-tumor setting

Conclusion: The results provide us with a deeper understanding of the possible evolution of normal, drug-responsive, and drug-resistant tumor cells during the cancer progression, which may contribute to improving the therapeutic strategies.
Source: Theoretical Biology and Medical Modelling - Category: Biomedical Science Authors: Source Type: research

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Authors: Palussière J, Catena V, Lagarde P, Cousin S, Cabart M, Buy X, Chomy F Abstract Non-small cell lung cancer (NSCLC) remains the leading cause of cancer death; percutaneous thermal ablation (TA) has proven feasibility, good local control and good tolerance in stage I tumors for patients with medical comorbidities and who are ineligible for surgery. In this context, stereotactic body radiotherapy (SBRT) has demonstrated high efficacy in treating T1 NSCLC and will need to be compared with percutaneous ablation. TA is also indicated in oligoprogressive disease; and can be proposed as a salvage treatment o...
Source: International Journal of Hyperthermia - Category: Internal Medicine Tags: Int J Hyperthermia Source Type: research
Publication date: September 2019Source: European Urology Supplements, Volume 18, Issue 6Author(s): G.K. Pooleri
Source: European Urology Supplements - Category: Urology & Nephrology Source Type: research
A 75-year-old man with isolated liver metastasis from prostate cancer refractory to systemic chemotherapy was referred for radioembolization (Fig 1). The chronically occluded celiac artery could not be traversed. Retrograde cannulation of the gastroduodenal artery was performed via the superior mesenteric artery using a 0.021-inch Direxion microcatheter (Boston Scientific, Marlborough, Massachusetts) and 0.016-inch Fathom wire (Boston Scientific) with successful catheterization of the right hepatic artery (Figs 2 –4).
Source: Journal of Vascular and Interventional Radiology : JVIR - Category: Radiology Authors: Tags: Extreme IR Source Type: research
ConclusionsEGCG can be used for cancer treatment. It increases the potency of several chemotherapeutics such as doxorubicin, cisplatin, and tamoxifen, in vivo and in vitro, in many cancers. MDR reversal by EGCG is facilitated by a plethora of mechanisms including oxidative and antioxidative responses, altered cell death and survival responses, suppression of oncogenic transcription factors, modulating the tumor microenvironment, and regulating multiple signal transduction pathways.
Source: Trends in Food Science and Technology - Category: Food Science Source Type: research
Publication date: Available online 20 September 2019Source: Cirugía Española (English Edition)Author(s): Vicente Munitiz, Angeles Ortiz, David Ruiz de Angulo, Luisa F. Martinez de Haro, Pascual ParrillaAbstractThere is significant controversy in the management of cardiac cancer. It seems unanimous that Siewert type I tumors be operated on as cancer of the esophagus and Siewert type III as gastric cancer. However, for “true” cancer of the gastric cardia or Siewert II, the authors do not agree. There is the obvious need for free proximal and distal margins, as well as correct lymphadenectomy. For so...
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 20 September 2019Source: Cirugía Española (English Edition)Author(s): Carles Pericay, Ismael Macías-Declara, Virginia Arrazubi, Laia Vilà, Miguel MarínAbstractAdenocarcinomas of the gastroesophageal junction represent 27% of all gastric tumors. In recent years, it has been classified as an entity of its own, with specific treatments that are sometimes differentiated from gastric treatments. Treatment can be based on chemotherapy (CTx) or chemoradiotherapy (CRTx) that is administered preoperatively (neoadjuvant), postoperatively (adjuvant) or perioperativ...
Source: Cirugia Espanola - Category: Surgery Source Type: research
Publication date: Available online 20 September 2019Source: Cirugía Española (English Edition)Author(s): Lourdes Sanz Álvarez, Estrella Turienzo Santos, José Luis Rodicio Miravalles, María Moreno Gijón, Sonia Amoza Pais, Sandra Sanz Navarro, Amaya Rizzo RamosAbstractFive-year survival of tumors of the esophagogastric junction is 50%, in the most favorable stages and with the most effective adjuvant treatments. More than 40% of patients will have recurrences within a short period, usually the first year after potentially curative surgery. Survival after this recurrence is usually le...
Source: Cirugia Espanola - Category: Surgery Source Type: research
ConclusionAtezolizumab regimens of 840  mg q2w and 1680 mg q4w are expected to have comparable efficacy and safety as the approved regimen of 1200 mg q3w, supporting their interchangeable use and offering patients greater flexibility.
Source: Cancer Chemotherapy and Pharmacology - Category: Cancer & Oncology Source Type: research
ConclusionCapOX therapy is feasible as adjuvant chemotherapy for locally advanced rectal cancer.
Source: International Journal of Clinical Oncology - Category: Cancer & Oncology Source Type: research
CONCLUSIONS: Results should support a policy of strengthening medical doctors' capabilities to communicate with patients, providing them complete information and involving them in the clinical decisions. Specifically, the findings should be used to improve current provision of cancer care by identifying areas of preferred intervention from the perspectives of patients in order to tailor the service supply accordingly. PMID: 31535573 [PubMed - as supplied by publisher]
Source: Current Medical Research and Opinion - Category: Research Tags: Curr Med Res Opin Source Type: research
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