Potential Drug–Drug and Drug–Condition Interactions among Fibromyalgia Patients Initiating Pregabalin or Duloxetine: Prevalence and Health Care Expenditure Impact

Abstract ObjectiveTo quantify the prevalence of potential drug–drug/drug–condition interactions (DDI/DCI) among fibromyalgia patients initiating pregabalin or duloxetine, and to determine the impact of potential DDI/DCI on health care expenditures. DesignRetrospective cohort study. SettingU.S. clinical practice, as reflected within a large administrative claims database. SubjectsFibromyalgia patients newly initiating pregabalin or duloxetine between July 1, 2008 and October 1, 2010 (initiation date = index). Outcome MeasuresPotential DDI measured using clinical software that identifies co‐prescription of medications that potentially interact with pregabalin or duloxetine. Potential DCI, drawn from the contraindications and warnings and precautions sections of pregabalin and duloxetine prescribing information, measured using administrative claims‐based algorithms. All‐cause health care expenditures measured throughout a 6‐month postindex period. Analyses included univariate, bivariate, and multivariable statistical approaches. ResultsSeven thousand seven hundred fifty‐one pregabalin and 7,785 duloxetine initiators were selected for study: mean age 49 years, 88% female. Only 1.4% of pregabalin initiators had ≥1 potential pregabalin DCI; none had potential pregabalin DDI. In contrast, 67% of duloxetine initiators had potential duloxetine DDI/DCI, driven mostly by potential duloxetine DDI (62% of duloxetine initiators). Compared between preg...
Source: Pain Medicine - Category: Anesthesiology Authors: Tags: Original Article Source Type: research

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Conclusions Exercise seems to affect circulating proteins, clinical characteristics, and muscle strength in FM. This study contributes to better understanding of systemic protein changes in FM compared with CON and how resistance exercise affects such changes.
Source: Medicine and Science in Sports and Exercise - Category: Sports Medicine Tags: BASIC SCIENCES Source Type: research
AbstractThe aim of this study was to investigate whether adding pain neuroscience education (PNE) to a multimodal approach has additional benefits in patients with fibromyalgia (FM). The methodology of this study was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The methods and strategies applied in the study were registered in PROSPERO (CRD42021272246). A systematic search with related search terms in the PubMed, Ebsco (Academic Search Ultimate), Cochrane Library, Physiotherapy Evidence Database (PEDro), Medline (Ebsco), Cinahl (Ebsco), Scopus and Web of Sc...
Source: International Journal of Rheumatic Diseases - Category: Rheumatology Authors: Tags: REVIEW Source Type: research
Different functional somatic syndromes (FSS), fibromyalgia (FMS) and other unexplained painful conditions share many common clinical traits and are characterized by troubling and functionally disabling somatic...
Source: Clinical Epigenetics - Category: Research Authors: Tags: Research Source Type: research
Fibromyalgia (FM) is characterised by chronic, continuous, widespread pain, often associated with a sense of fatigue, non-restorative sleep and physical exhaustion. Due to the nature of this condition and the absence of other neurological issues potentially able to induce disorders in body representations per se, it represents a perfect model since it provides an opportunity to study the relationship between pain and the bodily self. Corporeal illusions were investigated in 60 participants with or without a diagnosis of FM by means of an ad hoc devised interview. In addition, motor imagery was investigated and illusions re...
Source: Frontiers in Human Neuroscience - Category: Neuroscience Source Type: research
Individuals with the fragile X premutation report symptoms of chronic pain from multiple systems, have increased incidence of comorbid conditions where pain is a prominent feature, and pathophysiology that supports disrupted pain regulation, inflammation, and energy imbalance. Less is known about how pain manifests for the subpopulation of carriers that develop the motor and cognitive changes of fragile X-associated tremor and ataxia syndrome (FXTAS), and how pain may differ between men and women. We gathered data collected from 104 males and females with FXTAS related to chronic pain, comorbid conditions related to pain, ...
Source: Frontiers in Psychiatry - Category: Psychiatry Source Type: research
The objective of this systematic review and meta-analysis was to evaluate the effects of exergame training on female patients with fibromyalgia syndrome (FMS), and outcome measurements mainly include overall functioning, pain perception, quality of life, exercise capacity, health perception, kinesiophobia and fatigue severity.DATA SOURCES: Five electronic databases (PubMed, Web of Science, PsycInfo, Scopus, and Cochrane Library) were searched from inception until June 24, 2021. In addition to search reviewing the reference lists of relevant papers by hand. Cochrane Collaboration's tool for assessing risk of bias was used t...
Source: Health Physics - Category: Physics Authors: Source Type: research
This study aimed to identify a physiological factor involved in the exacerbated pain response to MHIE in people with FM by examining their inflammatory response to a bout of high-intensity exercise (HIE).MethodsIn this prospective study, 26 participants with FM and 9 healthy controls were recruited. The participants were subjected to a bout of HIE on a recumbent cycle ergometer with their blood samples collected at three time points (pre-HIE, HIE peak, and 1-h post-HIE). The primary outcomes were levels of the pro-inflammatory interleukins IL-6 and IL-8, and anti-inflammatory IL-10 at each of the three time points. Pain in...
Source: Sport Sciences for Health - Category: Sports Medicine Source Type: research
AbstractFibromyalgia (FM) is a condition characterized by chronic widespread pain whose pathogenesis is still not fully defined. Evidence based on structural and functional neuroimaging methods, electrophysiological, and morphological – skin biopsy – features demonstrated a central and peripheral nervous system involvement. A dysfunction in nociceptive inputs processing at the central level was highlighted as the primary cause of FM, but other data coming from different laboratories contributed to emphasize again the peripher al origin of FM. In fact, small fibers neuropathy (SFN) was observed in a large number...
Source: Neurological Sciences - Category: Neurology Source Type: research
The objective of this systematic review and meta-analysis was to evaluate the effects of exergame training on female patients with fibromyalgia syndrome (FMS), and outcome measurements mainly include overall functioning, pain perception, quality of life, exercise capacity, health perception, kinesiophobia and fatigue severity.
Source: Archives of Physical Medicine and Rehabilitation - Category: Rehabilitation Authors: Source Type: research
CONCLUSION: Our clinic model provides a framework for the treatment of patients with debilitating centrally sensitized conditions and future expansion of virtual care delivery models to better meet patient care and educational needs.PMID:35005437 | PMC:PMC8715289 | DOI:10.1016/j.mayocpiqo.2021.11.003
Source: Pain Physician - Category: Anesthesiology Authors: Source Type: research
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