Mapping the mosquito
Uncovering how mosquitoes sniff out their human victims may lead to new tools to conquer malaria and dengue fever. Emma Davies reports
AbstractBackgroundCurrent urban vector control strategies have failed to contain dengue epidemics and to prevent the global expansion ofAedes-borne viruses (ABVs: dengue, chikungunya, Zika). Part of the challenge in sustaining effective ABV control emerges from the paucity of evidence regarding the epidemiological impact of anyAedes control method. A strategy for which there is limited epidemiological evidence is targeted indoor residual spraying (TIRS). TIRS is a modification of classic malaria indoor residual spraying that accounts forAedes aegypti resting behavior by applying residual insecticides on exposed lower sections of walls (
In conclusion, the mkDNA-based qPCR assay that we developed in this study can be used not only for diagnosis of both cutaneous and visceral leishmaniasis with high sensitivity and specificity, but also for evaluating the severity and treatment efficacy of this disease, presenting a rapid and accurate tool for clinical surveillance, treatment monitoring and the end point determination of leishmaniasis.
This study covers all public and private sectors of medical biology located in metropolitan and overseas France and also extends to the French-speaking world. This article presents the testimonies and data obtained for the "Overseas and French-speaking countries" sub-working group made up of 45 volunteer correspondents, located in 20 regions of the world. In view of the delayed spread of the SARS-CoV-2 virus, the overseas regions and the French-speaking regions have benefited from feedback from the first territories confronted with COVID-19. Thus, the entry of the virus or its spread in epidemic form could be avo...
ConclusionsThe present study found that there was a high prevalence of severe malaria among patients withPlasmodium and DENV co-infection. Physicians in endemic areas where these two diseases overlap should recognize that patients with this co-infection can develop either severe malaria or severe dengue with bleeding complications, but a greater risk of developing severe dengue than severe malaria was noted in patients with this co-infection.Trial registrationThe protocol of this study was registered at PROSPERO:CRD42020196792.
ConclusionAs we have seen in this review, many important developments in our basic understanding of GCX structure, function and role in diseases have been described since the 2007 paper. The future is wide open for continued GCX research.
Background: Arboviral diseases are, after malaria, the most important vector-borne causes of mortality and morbidity around the world. In the last five years, dengue has continued to expand its geographic range and 390 million dengue infections occur every year (95% confidence interval 284 –528 million). Accidentally, or as a result of domestication and adaptation, some arboviruses are introduced to human settlements and if their ecological requirements (vector and hosts) are met, they can become established and cause outbreaks.
Intercultural bilingual school at Andahuaylas province, Peru. Photo courtesy Sergio Chaparro Hernández (CESR) By Laura Adriaensens and Sergio Chaparro HernándezANTWERP, Belgium / BOGOTA, Colombia, Sep 11 2020 (IPS) “It’s a major paradox, no?” asks Hugo Ñopo, a researcher at the Peruvian think tank Group for the Analysis of Development (GRADE). Since the beginning of the pandemic, Peru has presented itself as an example for the region: it quickly implemented drastic prevention measures, followed scientific recommendations and prepared an economic support plan for the most vulnerable se...
los G Abstract Mosquito-transmitted diseases, including malaria and dengue, are a major threat to human health around the globe, affecting millions each year. A diverse array of next-generation tools has been designed to eliminate mosquito populations or to replace them with mosquitoes that are less capable of transmitting key pathogens. Many of these new approaches have been built on recent advances in CRISPR/Cas9-based genome editing. These initiatives have driven the development of pathogen-resistant lines, new genetics-based sexing methods, and new methods of driving desirable genetic traits into mosquito popu...
ConclusionIn this trial there is some evidence of a spillover indirect effect of the intervention, with the Breteau index tending to be lower in locations which are more surrounded by locations in the intervention arm.
Conclusions: This study is the first extensive characterisation of the clinical analysis and immune biomarkers of several clinically important febrile infections in Saudi Arabia. Importantly, an immune signature with robust accuracy, specificity and sensitivity in differentiating several febrile infections was identified, providing useful insights into patient disease management in the Arabian Peninsula. PMID: 32864128 [PubMed]