The Nordic long-term OCD treatment study (NordLOTS): rationale, design, and methods
Conclusions: This multicenter trial covering three Scandinavian countries is going to be the largest CBT-study for paediatric OCD to date. It is not funded by industry and tries in the short and long-term to answer the question whether further CBT or SSRI is better in CBT non-responders.
ConclusionsThis study provides information about Aβ plaque burden, tau tangle burden, and neurodegeneration in cognitively unimpaired persons at three levels of genetic risk for AD. Unimpaired APOE ϵ4 HMs can be studied before their 70s to evaluate the understanding of factors, processes, and interventions involved in the predisposition to and prevention of AD, and after their 70s, to discover factors, processes, and interventions involved in the resilience or resistance to and prevention of AD.
Publication date: Available online 10 December 2019Source: American Journal of OtolaryngologyAuthor(s): Evette Ronner, Razan Basonbul, Rupal Bhakta, Leila Mankarious, Daniel J. Lee, Michael S. CohenAbstractObjectiveEvaluate the impact of cochlear anomalies on hearing outcomes for pediatric patients with cochlear implants.Study designRetrospective chart review.SettingTertiary care center.Subjects and methodsCharts were retrospectively reviewed for cases where pediatric cochlear implant surgery was performed between 2002 and 2018 at a single, tertiary care institution. Patients were divided into groups based on the presence ...
Conclusions: Our data suggest that thyroid hormones influence angiogenic signaling in MSCs via integrin αvβ3 and further substantiate the anti-angiogenic activity of Tetrac in the tumor microenvironment. PMID: 31816265 [PubMed - as supplied by publisher]
CONCLUSIONS: PD-L1 inhibitors lead to immune mediated thyroiditis, the most frequent endocrine IRAE. In most cases, management is supportive without requiring steroids or discontinuation of immunotherapy. Diffusely increased thyroid 18FDG uptake on PET scan may predict the occurrence of thyroiditis, whereas TPO antibodies may help identify its severity. Thyroiditis may be a biomarker for anti-tumor immune response, highlighting the need to further characterize its underlying mechanism. PMID: 31813343 [PubMed - as supplied by publisher]
ConclusionsPMMA acrylic resin base material was superficially modified through the incorporation of carboxylic acid groups by using PAA and PIA coatings that reduced the adherence of C albicans biofilm by 90%.
Publication date: November 2019Source: Chinese Journal of Natural Medicines, Volume 17, Issue 11Author(s): Mei-Qi WAN, You-Bo ZHANG, Xiao-Yan LIU, Ke-Ming LI, Ling-Yun JIA, Xiu-Wei YANGAbstractAngelicae Pubescentis Radix (APR), a widely used traditional Chinese medicine (TCM), is mainly used to treat rheumatism and headache diseases. Angelol B is one of the bioactive constituents of APR with significant anti-inflammatory activity. This paper is aimed to illustrate the metabolites of angelol B in vivo. To achieve this objective, a metabolomics approach based on a rapid and accurate UPLC-Q-TOF-MS method was used to detect th...
ConclusionOur protocol serves as a guide for precise localization of entire CSA and to ensure adequate dose to the large and complex targets. It can also be adapted for other complex treatment techniques such as total-marrow-irradiation and total-lymphoid-irradiation.
ConclusionsThe findings of this study support the usefulness of PET/CT in the detection of subcutaneous MZL, and in staging and treatment decisions.
CONCLUSIONS: We summarized the current tendency and limitations as well as future challenges in this field. The development of CAD needs to meet the rigid clinical requirements, such as high accuracy, strong robustness, high efficiency, fine-grained analysis and classification, and to provide practical clinical functions. This review provides helpful information for both engineering researchers and radiologists to learn the latest development of CAD systems. PMID: 31815727 [PubMed - as supplied by publisher]
This study presents an exploratory characterization on the effect of build orientation on deformation behavior of Ti–6Al–4V rods produced through electron beam melting (EBM). Microstructural differences in horizontally and vertically printed rods were characterized using optical microscopy, scanning electron microscopy (SEM), transmission electron microscopy (TEM) coupled with energy dispersive spectroscopy (EDS), and electron backscatter diffraction (EBSD). A typical microstructure of the alloy consists of primary-α and vanadium-enriched β-phases. Compared to the horizontal samples, vertically print...