Feeding and Bone Turnover in Gastric Bypass.

Feeding and Bone Turnover in Gastric Bypass. J Clin Endocrinol Metab. 2013 Nov 25; Authors: Valderas JP, Padilla O, Solari S, Escalona M, González G Abstract Context:Roux-en-Y Gastric bypass (RYGB) is associated with high bone turnover. In healthy subjects, feeding causes acute reduction of bone resorption, which is regulated by several intestinal and pancreatic peptides.Objective:To assess bone turnover after feeding in patients with RYGB.Design:A cross-sectional, case-control study.Setting:University Hospital.Participants:Fifteen postmenopausal women, who underwent RY GB 7.4 ± 4.1 years before, were matched by age and BMI with 15 non-operated women (Controls).Main outcomes:Serum PTH, calcium, phosphorus, insulin, carboxytelopeptide (CTX), procollagen type I N-terminal propeptide (P1NP) and GLP-2 were measured in fasting and after a standard meal (SM).Results:The fasting calcium, phosphorus and PTH were similar in both groups and exhibited similar decreases after SM. The fasting CTX level was higher in the RYGB than in the Control groups (0.589 ± 0.18 vs. 0.382 ± 0.11 ng/ml; P
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research

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