Colorectal cancer and the elderly.

This article explores the evidence for screening and surveillance in the elderly, and addresses key challenges unique to this population. PMID: 24267607 [PubMed - in process]
Source: Clinical Colorectal Cancer - Category: Cancer & Oncology Authors: Tags: Clin Geriatr Med Source Type: research

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ConclusionLactobacillus coryniformis MXJ32 could effectively ameliorate CA-CRC via regulating intestinal microenvironment, alleviating inflammation, and intestinal barrier damage, which further suggested thatL. coryniformis MXJ32 could be considered as a functional food ingredient for the alleviation of CA-CRC.Graphic abstract
Source: European Journal of Nutrition - Category: Nutrition Source Type: research
Discussion Bloody stools or blood in the diaper is a relatively common complaint in general pediatrics. For most patients it is often a minor concern. Commonly it is a transient problem (e.g. rectal fissure caused by constipation or trauma) or often not blood (e.g. urate crystals in the diaper, food, menses, etc.). Real blood does occur with an identifiable cause such as long distance running or heavy exercise, or milk protein allergy/sensitivity that improves with a milk-restricted diet. Many more serious causes are associated with heavier or more recalcitrant bleeding, increased defecation, abdominal pain, poor eating an...
Source: PediatricEducation.org - Category: Pediatrics Authors: Tags: Uncategorized Source Type: news
Polymeric nanoparticles are widely studied in the treatment of colorectal cancer. Kaempferitrin-loaded nontoxic and biodegradable poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) developed by the solvent emulsion evaporation method by improving its solubility and bioavailability. In order to improve the delivery of kaempferitrin (KM) to cancerous cells, folic acid (FA) combined kaempfertrin PLGA NPs were prepared. The goal of the study was whether PLGA NPs with surface KM and FA could help to prevent colorectal cancer. AbstractPolymeric nanoparticles are widely studied in the treatment of colorectal cancer. Kae...
Source: Biotechnology and Applied Biochemistry - Category: Biochemistry Authors: Tags: ORIGINAL ARTICLE Source Type: research
This study aimed to examine the difference in HRQoL by participants ’ characteristics and to investigate the determinants of health-related quality of life HRQoL among Omani hospitalized patients with cancer.MethodsThis cross-sectional study was conducted in two oncology centers in Oman. Omani hospitalized patients with breast, thyroid, colorectal, stomach, and prostate cancer were recruited using convenience sampling. Participants completed Arabic versions of Pittsburgh Sleep Quality Index to measure sleep quality, Brief Fatigue Inventory scales to measure fatigue, and Functional Assessment of Cancer Therapy to meas...
Source: Quality of Life Research - Category: Health Management Source Type: research
In this study, novel iron oxide-gold core –shell hybrid nanocomposites (Fe3O4@Au HNCs) coated with alginate hydrogel carrying doxorubicin (DOX) were constructed for targeted photo-chemotherapy and magnetic resonance imaging (MRI). The magnetic core enables the HNCs to be detected through MRI and targeted towards the tumor using an external magnetic field, a method known as magnetic drug targeting (MDT). The Au shell could respond to light in the near-infrared (NIR) region, generating a localized heating for photothermal therapy (PTT) of the tumor. The cytotoxicity assay showed that the treatment of CT26 colon cancer ...
Source: Lasers in Medical Science - Category: Laser Surgery Source Type: research
ConclusionThis study elucidated the vascular anatomy and positional relationship with surrounding organs that is required in central vascular ligation during complete mesocolic excision for right sided colon cancer.
Source: Japanese Journal of Radiology - Category: Radiology Source Type: research
This study aimed to evaluate its impact on these variables and compare it with that of emergency surgery (ES).MethodsDescriptive, retrospective and single-centre study, performed between 2008 and 2015, with follow-up until 2017. One hundred eleven patients with diagnosis of left malignant colonic obstruction were included and divided according to the treatment received: stent as bridge to surgery (SBTS group: 39), palliative stent (PS group: 30) and emergency surgery with curative (ECS group: 34) or palliative intent (EPS group: 8). Treatment was decided by the attending surgeon in charge.ResultsTechnical and clinical gene...
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
Molecules, Vol. 27, Pages 737: Anti-Cancer Effects of α-Cubebenoate Derived from Schisandra chinensis in CT26 Colon Cancer Cells Molecules doi: 10.3390/molecules27030737 Authors: Jeong Eun Gong Ji Eun Kim Su Jin Lee Yun Ju Choi You Jeong Jin Young Whan Choi Sun Il Choi Dae Youn Hwang α-Cubebenoate derived from Schisandra chinensis has been reported to possess anti-allergic, anti-obesity, and anti-inflammatory effects and to exhibit anti-septic activity, but its anti-cancer effects have not been investigated. To examine the anti-cancer activity of α-cubebenoate, we investigate...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
Eur J Med Chem. 2022 Jan 12;230:114118. doi: 10.1016/j.ejmech.2022.114118. Online ahead of print.ABSTRACTMethyltransferase complex, such as METTL3/METTL14/WTP, catalyze N6-methyladenosine (m6A), which is the most abundant mRNA modification in mammals. Besides acting as a m6A methyltransferase, METTL3 also regulates mRNA translation and other biological processes. Studies have identified numerous roles and molecular mechanisms associated with METTL3 in multiple biological processes especially in tumors in recent years. Furthermore, targeting METTL3 as an efficient therapeutic way for the treatment of different kinds of tumo...
Source: European Journal of Medicinal Chemistry - Category: Chemistry Authors: Source Type: research
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