Cardiorespiratory and antinociceptive effects of two different doses of lidocaine administered to horses during a constant intravenous infusion of xylazine and ketamine

Conclusions: At the highest dose administered (THL) lidocaine CRI during xylazine/ketamine anesthesia decreased BIS and motor response to noxious stimulation, and prolonged recovery time without significant added cardiorespiratory depression.
Source: BMC Veterinary Research - Latest articles - Category: Veterinary Research Authors: Source Type: research

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Recently, Lin et  al1 suggested that high-flow nasal cannula oxygen therapy was superior to 2 L/min by nasal cannula in terms of the incidence of hypoxia and severe hypoxia among America Society of Anesthesiologists class I–II patients undergoing elective gastroscopy with low-dose propofol sedation (mean dose, 10 6 mg). Hypoxia and severe hypoxia occurred in 8.4% of patients with nasal 2 L/min cannula oxygen therapy versus 0.6% of patients with high-flow oxygen. This differs markedly from our experience with low-dose propofol sedation for diagnostic EGD done without routine supplemental oxygen.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Letter to the Editor Source Type: research
Objectives It remains controversial whether a subanesthetic dose of ketamine could modulate the antidepressant effect of electroconvulsive therapy (ECT) in patients with major depressive disorder. We investigated the effect of ketamine on accelerating the antidepressant efficacy of ECT. Methods One hundred twenty-seven patients with major depressive disorder were included in this randomized, placebo-controlled, double-blind study. The study group received 0.3 mg/kg ketamine, and the control group received an isovolumetric dose of normal saline before undergoing ECT under propofol anesthesia. The main outcome was the H...
Source: The Journal of ECT - Category: Psychiatry Tags: Original Studies Source Type: research
PMID: 32068588 [PubMed - in process]
Source: Anesthesia and Analgesia - Category: Anesthesiology Authors: Tags: Anesth Analg Source Type: research
Publication date: Available online 19 February 2020Source: Chemico-Biological InteractionsAuthor(s): Guo-liang Liu, Yun-feng Cui, Chang Lu, Peng ZhaoAbstractKetamine is gaining ground as a potential treating depression because it has a distinct mode of action than typical drugs that influence monoamine neurotransmitters including noradrenaline, dopamine, or serotonin. Ketamine is thought to act by blocking N-methyl-d-aspartate (NMDA) receptors in the brain, which interact with the amino acid neurotransmitter glutamate. The resultant chemical changes in the brain caused by ketamine are not yet fully understood but could inv...
Source: Chemico Biological Interactions - Category: Biochemistry Source Type: research
By GREG HAMMER, MD Burnout among healthcare professionals is at an all-time high. Its drivers include longer work hours, the push to see more patients, more scrutiny by administrators, and loss of control over our practice. We seem to spend more time with the electronic medical record and less time face-to-face with our patients. I have faced burnout personally. My son passed away at the age of 29, which was beyond painful. At the same time, I felt burdened by the growing number and complexity of metrics by which I was judged at work. Days in the operating room and intensive care unit seemed more and more exhausting,...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Physicians Burnout GAIN GAIN without Pain: The Happiness Handbook for Health Care Professionals Greg Hammer physician burnout physician wellness Source Type: blogs
In this study, it was aimed to demonstrate the change in quality of life, depression, anxiety, and sleep disturbance scores before and after treatment in CM patients who underwent GONB and the effectiveness of treatment.Patients and methodsThe study included 84 patients diagnosed as CM according to the International Classification of Headache Disorders III beta version diagnostic criteria. The 24-Hour Migraine Quality of Life Questionnaire (MQoLQ), Migraine Disability Assessment Scale (MIDAS), Beck Anxiety Inventory (BAI), Beck Depression Inventory (BDI), Pittsburgh Sleep Quality Index (PSQI), Headache Impact Test (HIT), a...
Source: Neurological Sciences - Category: Neurology Source Type: research
Perrotti LI Abstract Ketamine, a dissociative anesthetic and psychedelic compound, has revolutionized the field of psychopharmacology by showing robust, and rapid-acting antidepressant activity in patients suffering from major depressive disorder (MDD), suicidal tendencies, and treatment-resistant depression (TRD). Ketamine's efficacy, however, is transient, and patients must return to the clinic for repeated treatment as they experience relapse. This is cause for concern because ketamine is known for its abuse liability, and repeated exposure to drugs of abuse often leads to drug abuse/dependence. Though the mech...
Source: Behavioural Brain Research - Category: Neurology Authors: Tags: Behav Brain Res Source Type: research
Conclusions In this trial, there does not appear to be a significant difference in electrocardiographic changes in patients with Brugada syndrome when propofolversus etomidate were administered for induction of anesthesia. This study did not investigate electrocardiographic changes related to propofol used as an infusion for maintenance of anesthesia, so future studies would be warranted before conclusions about safety of propofol infusions in patients with Brugada syndrome can be determined.Editor ’s PerspectiveWhat We Already Know about This TopicBrugada syndrome is an inherited cardiac ion channel disorder that pl...
Source: Anesthesiology - Category: Anesthesiology Source Type: research
Compared with local anesthesia, general anesthesia was associated with a 54% increased odds of postpartum depression, and a 91% higher risk of suicidal thoughts or self-inflicted injury.
Source: WebMD Health - Category: Consumer Health News Source Type: news
TUESDAY, Feb. 11, 2020 -- General anesthesia for cesarean delivery is associated with increased odds of severe postpartum depression (PPD), suicidal ideation, and self-inflicted injury, according to a study published online Jan. 29 in Anesthesia...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
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