InterFuse L Modular Implant from Vertebral Technologies Receives FDA 510(k) Clearance

Lateral lumbar interbody fusion is a minimally invasive procedure to remove spinal discs damaged by degenerative disc disease, and replace them with bone graft implants. By entering through the patient’s side, the major back muscles and nerves ...
Source: Medgadget - Category: Technology Consultants Authors: Tags: Orthopedic Surgery Source Type: blogs

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Congenital pseudarthrosis of the tibia is defined as a non-union of a tibial fracture that develops in a dysplastic bone segment of the tibial diaphysis. Pathologically, a fibrous hamartoma surrounds the bone at the congenital pseudarthrosis of the tibia site. The cases of 25 children, who have congenital pseudarthrosis of the tibia, were included in this study. Their ages ranged from 15 months to 15 years at the time of treatment. Neurofibromatosis-1 was present in 24 children. They were managed according to our classification system and treatment protocol. The treatment for mobile pseudarthrosis (types 1 and 2) included ...
Source: Journal of Pediatric Orthopaedics B - Category: Orthopaedics Tags: Leg & Foot Source Type: research
Contributors : Ming yu ; Divyansh Agarwal ; Laxminarayana Korutla ; Catherine L May ; Negin N Griffith ; Wei Wang ; Andrei Georgescu ; Bernard Herring ; Omaida C Velazquez ; Prasanth Vallabhjosyul ; James F Markmann ; Chengyang Liu ; Ali NajiSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Homo sapiensThe intrahepatic milieu is inhospitable to intraportal islet allografts, limiting their applicability to ameliorate Type 1 Diabetes (T1D). Islet viability in the subcutaneous space represents an unfulfilled paradigm that is crucial to ensure widespread adoption and safety of clinical islet transp...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Non-coding RNA profiling by high throughput sequencing Homo sapiens Source Type: research
Cutting the medial collateral ligament (MCL), even in part, seems counterintuitive. However, medial meniscal surgery is not always easy, and iatrogenic articular cartilage damage can be a complication of partial meniscectomy, meniscus repair, and/or allograft transplantation in a tight knee. Fortunately, partial tears of the MCL tend to heal, and most patients do tolerate iatrogenic, partial MCL tearing without negative long-term sequelae. However, rather than accidentally tearing the MCL during medial meniscal surgery, if you need room to operate, partially release the MCL.
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - Category: Surgery Authors: Tags: Editorial Source Type: research
Studies comparing outcomes of different treatments are always intriguing, so I read the article by Puzzitiello et  al. with interest.1 Based on telephonic mean follow-up of approximately 5 years, the authors found greater rate of re-dislocation following medial patellofemoral ligament (MPFL) repair/imbrication in 19 knees as compared with reconstruction using hamstring autograft, hamstring allograft, or tibial is anterior allograft in 32 knees. The authors are to be congratulated for undertaking this retrospective review, but I did not find where follow-up duration was analyzed between the repair and reconstructed gro...
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - Category: Surgery Authors: Tags: Letter to the Editor Source Type: research
Graft choice for anterior cruciate ligament reconstruction has been a great controversy in the sports medicine literature for the last 25 years. It has been well studied in the orthopaedic literature, with numerous randomized control trials and large database studies. There remain advantages and disadvantages to each autograft choice, primarily bone –patellar tendon–bone, quadrupled hamstring, as well as allograft. More recently, quadriceps autograft has also been studied as a suitable alternative.
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - Category: Surgery Authors: Tags: Editorial Commentary Source Type: research
Recurrent rotator cuff tears are a frequent cause of shoulder disability. To repair a rotator cuff, the surgeon faces both mechanical and biological challenges. Patch use as a scaffold for rotator cuff repair is well-described, as is biological augmentation, with clinical indications and efficacy being the subjects of ongoing study. However, a clinical report of dermal allograft patch augmentation combined with attempts at supercharging the biology is novel. This technique would benefit from controlled, prospective studies, with tight inclusion criteria.
Source: Arthroscopy - Journal of Arthroscopic and Related Surgery - Category: Surgery Authors: Tags: Editorial Commentary Source Type: research
J Knee Surg DOI: 10.1055/s-0040-1710521The purpose of this systematic review was to reveal the trend in surgical technique and tunnel targets points and placement in anatomical single-bundle anterior cruciate ligament (ACL) reconstruction. Following the Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement, data collection was performed. PubMed, EMBASE, and Cochran Review were searched using the terms “anterior cruciate ligament reconstruction,” “anatomic or anatomical,” and “single bundle.” Studies were included when they reported clinical results, surgic...
Source: Journal of Knee Surgery - Category: Orthopaedics Authors: Tags: Original Article Source Type: research
CONCLUSION: The future of organ bioengineering relies on furthering understanding of organogenesis, in vivo regeneration, regenerative immunology and long-term monitoring of implanted bioengineered organs. PMID: 32463143 [PubMed - in process]
Source: The British Journal of Surgery - Category: Surgery Authors: Tags: Br J Surg Source Type: research
Authors: Pablo A, Breaud AR, Clarke W Abstract Bone marrow transplantation is used to treat particular types of cancers such as lymphoma, leukemia, and multiple myeloma. Appropriate dosing of busulfan during the preparative phase is critical for a successful allograft; if blood concentrations get too high significant liver toxicity can occur, if blood concentrations are too low, then graft-versus-host disease (GVHD) can develop. Busulfan monitoring in blood allows hospitals with the opportunity to provide individualized medicine to patients and improve overall patient outcome. Liquid Chromatography-Tandem Mass Spec...
Source: Current Protocols in Toxicology - Category: Toxicology Tags: Curr Protoc Toxicol Source Type: research
Authors: Sun YQ, Li SQ, Zhao XS, Chang YJ Abstract INTRODUCTION: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains a curable strategy for acute lymphoblastic leukemia (ALL), especially for adult cases. However, leukemia relapse after allograft restricts the improvement of transplant outcomes. Measurable residual disease (MRD) has been the strongest predictor for relapse after allo-HSCT, allowing MRD-directed preemptive therapy. AREAS COVERED: This manuscript summarizes the detection of MRD in patients with ALL who undergo allo-HSCT, focusing the effects of positive pre-HSCT MRD and post-HSC...
Source: Expert Review of Anticancer Therapy - Category: Cancer & Oncology Tags: Expert Rev Anticancer Ther Source Type: research
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