Four UCLA stem cell researchers receive CIRM Early Translational grants
Four researchers from UCLA’s Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research have received Early Translational Research Awards totaling approximately $13 million from the California Institute for Regenerative Medicine, the state's stem cell agency. The UCLA researchers received four of the 12 total awards; no other institution received more than one. The Independent Citizens Oversight Committee, CIRM’s governing body, announced at its Aug. 28 meeting in La Jolla, Calif., that grant recipients included Dr. Jerome Zack, professor of medicine and microbiology, immunology and molecular genetics; Dr. Robert Reiter, Bing Professor of Urologic Research; Dr. Donald Kohn, professor of pediatrics and microbiology, immunology and molecular genetics in the life sciences; and Dr. Gerald Lipshutz, associate professor-in-residence of surgery, urology and medicine. The grants are part of CIRM’s Early Translational Research Initiative, which aims to advance promising, innovative discoveries using stem cells. In this "early translation" phase, scientists are expected to do research that will result in the development of drugs or cellular therapies to be used in FDA-approved clinical trials, translating discoveries from the laboratory to the clinic as quickly as possible. "Our CIRM grants highlight the excellence of the UCLA bench-to-bedside research program," said Dr. Owen Witte, director of the Broad ...
Conclusions This study provides evidence for enhanced myokine expression and tumor-suppressive effects of serum from chronically exercise-trained prostate cancer patients on androgen deprivation therapy.
Purpose Reduced lean body mass (LBM) is common during and after treatment for breast cancer, and it is associated with increased treatment-induced toxicity, shorter time to tumor progression, and decreased survival. Exercise training is a potential intervention for maintaining or increasing LBM. We conducted a systematic review and a meta-analysis to investigate the effects of exercise training on LBM in breast cancer. Methods A comprehensive search was performed to November 2020 for randomized controlled trials reporting the effects of structured exercise training on LBM compared with control in women with brea...
Conclusions The hypoalgesic effects induced by the isometric exercise were not only localized to the moving part of the body but also can be extended to the distal part of the body. The exercise intensities play a vital role in modulating these effects. Exercise-induced hypoalgesia could be related to the modulation of nociceptive information transmission via a spinal gating mechanism and also rely on a top-down descending pain inhibitory mechanism.
Conclusions Exercise seems to affect circulating proteins, clinical characteristics, and muscle strength in FM. This study contributes to better understanding of systemic protein changes in FM compared with CON and how resistance exercise affects such changes.
This study aimed to identify characteristics and movement-based tests that predict upper quadrant musculoskeletal injury (UQI) in military personnel over a 12-month follow-up. Methods A prospective observational cohort study of military members (n = 494; 91.9% male) was conducted. Baseline predictors associated with UQI were gathered through surveys and movement-based tests. Survey data included demographic information, injury history, and biosocial factors. Movement-based tests include the following: Y Balance Tests (YBT), Functional Movement Screen, Selective Functional Movement Assessment lumbar multisegmental mo...
Anyone have experience and interested in performing CSF catheterization for a phase 1 clinical trial in New Jersey? Or do you know anyone interested? If interested DM me please.
Any tips on how to legally and easily bill for a Level 5 for New and Established patients? I imagine one could argue for “severe progression of a chronic disease” easily. That’s one category. We need to then look at the other two categories… Category 1 I’m not sure if a simple ESI or MBB or whatever would count for a “major surgery” for the risk category. I’m also unsure if UDS would count for “invasive drug monitoring.” Note: if it does then I can see how established patients... Read more
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ConclusionLactobacillus coryniformis MXJ32 could effectively ameliorate CA-CRC via regulating intestinal microenvironment, alleviating inflammation, and intestinal barrier damage, which further suggested thatL. coryniformis MXJ32 could be considered as a functional food ingredient for the alleviation of CA-CRC.Graphic abstract
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