'The TIPSing Point'

This study evaluated the earlier use of TIPS in such patients. Methods: Objective: The study was conducted to determine if early treatment with extended polytetrafluoroethylene (e-PTFE), can improve outcomes in patients with cirrhosis and acute variceal bleeding who are at high risk for treatment failure and death.Setting: Patients were enrolled at nine European centers between May2004 and March 2007. Study Design: Randomization was performed within 24 hours after admission. The randomization sequence was generated by computer with the use of a concealed block size of four. The coded treatment assignments were kept at the coordinating center in sealed, consecutively numbered, opaque envelopes.Subjects: Eligible patients had cirrhosis with acute esophageal variceal bleeding that was being treated with a combination of vasoactive drugs, endoscopic treatment, and prophylactic antibiotics. Patients had Child-Pugh class C disease (a score of 10 to 13) or they had class B disease (a score of 7 to 9) but with active bleeding at diagnostic endoscopyExclusion criteria were an age of more than 75 years, pregnancy, hepatocellular carcinoma that did not meet the Milano criteria for transplantation(i.e., a single lesion
Source: BioMed Central - Category: Journals (General) Authors: Source Type: research

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ConclusionIn a national cohort of CIED implantations we demonstrate that women are at an overall higher risk of procedure-related adverse events compared to men, but no increased risk of all-cause mortality. Further studies are required to identify procedural techniques that would improve outcomes amongst women undergoing such procedures.
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 22 August 2019Source: Canadian Journal of CardiologyAuthor(s): Seleman Reza Bsc, Natalia Pinilla, Emilie P. Belley-Côté, Kevin J. Um, Serena Sibilio, Madhu K. Natarajan, Richard P. WhitlockAbstractOptimal post-procedural antithrombotic regimen is uncertain after transcatheter aortic valve replacement (TAVR). We developed an online questionnaire on post-TAVR antithrombotic management. After research ethics board approval, we distributed the survey to TAVR implanters across Canada. A total of 24 TAVR implanters from 17 centres responded to the survey for a response rate of 75%....
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Publication date: Available online 21 August 2019Source: Seminars in Cancer BiologyAuthor(s): Yue Zhao, Jiahui Li, Dai Li, Zhefang Wang, Jiangang Zhao, Xiaolin Wu, Qiye Sun, Peter Ping Lin, Patrick Plum, Menglong Zhou, Zhen Zhang, Hans Schlösser, Peter J. Nelson, Christiane J. BrunsAbstractMore than 70% of gastrointestinal (GI) cancers are diagnosed with metastases, leading to poor prognosis. For some cancer patients with limited sites of metastatic tumors, the term oligometastatic disease (OMD) has been coined as opposed to systemic polymetastasis (PMD) disease. Stephan Paget first described an organ-specific pattern...
Source: Seminars in Cancer Biology - Category: Cancer & Oncology Source Type: research
ConclusionPPI use was associated with an increased risk of gastric and oesophageal cancer and the risk remained increased over follow-up. These results support our original hypothesis that use of PPIs may be a risk factor for gastric and oesophageal cancer in the general population of maintenance users, independent of underlying indications.
Source: Cancer Epidemiology - Category: Cancer & Oncology Source Type: research
Publication date: Available online 21 August 2019Source: Anaesthesia &Intensive Care MedicineAuthor(s): Naomi Fleming, Rowena CockerhamAbstractGeneral anaesthesia in obstetrics is reducing with a reported use in only 4% of caesarean sections in 2017–2018. Obstetric surgery is often urgent, requiring effective team communication and a rapid, focused preoperative assessment. Physiological changes of pregnancy increase the incidence of aspiration, desaturation and failed intubation. In addition, the rapidly evolving circumstances add additional stress, impacting on performance. Hypotension from aortocaval compr...
Source: Anaesthesia and intensive care medicine - Category: Anesthesiology Source Type: research
Authors: Bada-Bosch T, Redondo B, Sevillano AM, Alonso M, Trujillo H, Auñón P, Polanco N, Rodríguez L, Gonzalez E, Andrés A PMID: 31431303 [PubMed - as supplied by publisher]
Source: Nefrologia : publicacion oficial de la Sociedad Espanola Nefrologia - Category: Urology & Nephrology Tags: Nefrologia Source Type: research
ConclusionsPulmonary metastasectomy is safe and effective treatment for well-selected patients with pulmonary metastasis of HCC. Liver recurrence at the time of pulmonary metastasectomy and the number of metastatic sites were identified as independent prognostic factors. The number of risk factors significantly influenced patient survival.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
ConclusionsAlthough cardiopulmonary complications can accompany salvage surgery, the procedure is generally safe. Survival outcome is encouraging, especially in cases with good response to initial treatment.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
Authors: Fischer Fumeaux CJ, Morisod Harari M, Weisskopf E, Eap CB, Epiney M, Vial Y, Csajka C, Bickle Graz M, Panchaud A Abstract Introduction: Depression affects 300 million individuals worldwide. While selective serotonin reuptake inhibitors (SSRI) are one of the first-line pharmacological treatments of major depression in the general population, there is still uncertainty regarding their potential benefits and risks during pregnancy. Areas covered: Outcomes requisite for a proper risk/benefit assessment of SSRI in pregnancy and lactation were considered: (a) potential risks associated with untreated depression,...
Source: Expert Opinion on Drug Safety - Category: Drugs & Pharmacology Tags: Expert Opin Drug Saf Source Type: research
ConclusionsThe incidence of neonatal listeriosis is increasing, especially in preterm neonates. Maternal listeriosis should be adequately treated with appropriate empirical antibiotics.
Source: Journal of Microbiology, Immunology and Infection - Category: Microbiology Source Type: research
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