Topical 4% nicotinamide vs. 1% clindamycin in moderate inflammatory acne vulgaris
This study aimed to compare efficacy of the topical 4% nicotinamide and 1% clindamycin gels in these patients. In this randomized, double‐blind clinical trial, patients with moderate inflammatory facial acne vulgaris were randomly allocated to receive either topical 4% nicotinamide (n = 40) or 1% clindamycin gels (n = 40) twice daily. In each group, they were further categorized in two subgroups with oily and non‐oily types of facial skin. The Cook's acne grade was determined at baseline and at weeks 4 and 8 post treatment. Acne grade decreased from an average of 5.93 ± 0.83 at baseline to 4.03 ± 1.33 at week 4 and 2.08 ± 1.59 at week 8 in nicotinamide receivers, and from an average of 5.70 ± 0.94 at baseline to 3.85 ± 1.66 at week 4 and 2.03 ± 1.53 at week 8 in the clindamycin group (within‐group P 0.05). Comparing with each other, nicotinamide and clindamycin gels were significantly more efficacious in oily and non‐oily skin types, respectively. No major side effect was encountered by any patient. Skin type is a significant factor in choosing between topical nicotinamide and clindamycin in patients with acne vulgaris.
Publication date: Available online 9 October 2020Source: Clinical Plasma MedicineAuthor(s): Dr. Arisi Mariachiara, Venturuzzo Anna, Gelmetti Alessandra, Guasco Pisani Edoardo, Bassissi Stefania, Rossi Mariateresa, Calzavara-Pinton Piergiacomo
Condition: Acne Interventions: Drug: Spironolactone; Drug: Doxycycline Hyclate Sponsor: University of Pennsylvania Not yet recruiting
CONCLUSIONS: Rosacea is an evolving condition; care should take into account all clinical signs and symptoms of rosacea that are present in an individual patient, understanding that symptoms may change over time, and utilize combination therapy when applicable to target all rosacea symptoms. J Drugs Dermatol. 2020;19(10): 929-934. doi:10.36849/JDD.2020.5367. PMID: 33026776 [PubMed - as supplied by publisher]
Recent advances in the medical treatment of acne make it"an exciting time" for treating patients with the condition.Medscape Medical News
Condition: Atrophic Acne Scar Intervention: Combination Product: Fractional laser with PRP fluid or PRP gel Sponsor: Yasmine Ahmed Abd El-Maguid El-Hadidy Recruiting
Molecules, Vol. 25, Pages 4563: (+)-Erythro-Δ8′-7S,8R-Dihydroxy-3,3′,5′-Trimethoxy-8-O-4′-Neolignan, an Anti-Acne Component in Degreasing Myristica fragrans Houtt Molecules doi: 10.3390/molecules25194563 Authors: Chia-Jung Lee Chun-Wei Huang Lih-Geeng Chen Ching-Chiung Wang Acne is a common skin condition observed in adolescents. Nutmeg (Myristica fragrans Houtt) (MF) is a well-known traditional Chinese medicine; its major toxic components, safrole and myristicin, are rich in essential oils. Essential oils of MF (MFO) were extracted by hydrodistillation; the residue was extracted...
BACKGROUND: Chronic illnesses belong to suicide risk factors. The goal of the current study was to estimate the rate of suicide-related behaviors in patients with atopic dermatitis, psoriasis, or acne from a third-person perspective (namely, Austrian derma...
Authors: Abbe CR, Page ST, Thirumalai A Abstract Unintended pregnancy is a global public health problem. Despite a variety of female contraceptive options, male contraceptive options are limited to the condom and vasectomy. Condoms have high failure rates and surgical vasectomy is not reliably reversible. There is a global need and desire for novel male contraceptive methods. Hormonal methods have progressed the furthest in clinical development and androgen plus progestin formulations hold promise as a marketable, reversible male contraceptive over the next decade. Investigators have tested androgen plus progestin ...