Chlamydia promotes gene mutations

(Max-Planck-Gesellschaft) Outcome of experimental Chlamydia infections points towards cancer.
Source: EurekAlert! - Medicine and Health - Category: Global & Universal Source Type: news

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The first-ever human trial of a genital-chlamydia vaccine suggests that it is safe and effective, according to a new study published in the Lancet. U.S. sexually transmitted illness diagnoses have reached new highs for the past four years in a row, and chlamydia is responsible for the bulk of those infections: 1.7 million cases were diagnosed in 2017 alone, according to the U.S. Centers for Disease Control and Prevention, compared to about 550,000 cases of gonorrhea, 40,000 cases of HIV and 30,000 cases of syphilis. Globally, the problem is even more widespread: about 127 million cases were diagnosed in 2016, according to ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized embargoed study Research Source Type: news
It ’s half a century since the first known HIV-related death and two patients appear to have been cured of the virus. What does this mean for the 37 million still living with it?Nobody knew what killed Robert Rayford. The African American boy was just 15 years old when he presented at St Louis city hospital in late 1968, but the medical team drew a blank.Unexplained swelling in Rayford ’s genitalia soon spread throughout his body. Chlamydia bacteria, usually localised at the point of entry, coursed through his bloodstream. A small purple lesion on the inside of his thigh signalled cancer, but of a form usually ...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Aids and HIV Medical research Health Source Type: news
Source: Cancer Management and Research - Category: Cancer & Oncology Tags: Cancer Management and Research Source Type: research
ConclusionsHPV and Ct behave as reciprocal risk factors. In women diagnosed with HPV infection or chlamydia, the screening for the mutual infection could represent a preventive intervention for severe reproductive health outcomes, such as cervical cancer and infertility.
Source: International Journal of Public Health - Category: International Medicine & Public Health Source Type: research
Wanbo Zhu1,2†, Jingyang Li1,3†, Faustina Pappoe4, Jilong Shen1* and Li Yu1* 1Department of Microbiology and Parasitology, Anhui Provincial Laboratory of Microbiology and Parasitology, Anhui Key Laboratory of Zoonoses, Anhui Medical University, Hefei, China 2Graduate School of Affiliated Anhui Provincial Hospital, Anhui Medical University, Hefei, China 3The Clinical Laboratory of the Third People’s Hospital of Heifei, Hefei, China 4Department of Microbiology and Immunology, School of Medical Sciences, University of Cape Coast, Cape Coast, Ghana One of the most successful intracellular paras...
Source: Frontiers in Microbiology - Category: Microbiology Source Type: research
In conclusion, a delicate balance of the complex system of nutrient sensing and mTOR (mTORC1) signaling is crucial to ensure appropriate development of DCs (23). Strikingly, loss of both mTOR complexes results in opposite effects on in vivo DC development compared with loss of mTORC1 alone, probably indicating differential inhibition of mTOR downstream targets and collaboration of mTOR complexes. Indeed, DC loss upon TSC1 deficiency is accompanied by increased DC apoptosis and enhanced metabolic activity due to TSC1-dependent inhibition of Myc, an effector downstream of mTOR (Figure 1), and reversed upon Myc loss (35). Of ...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study we found blocking autophagy led to increased CP growth in both macrophages and mouse embryonic fibroblasts. In vivo, loss of the autophagy elongation component ATG16L1 specifically in myeloid cells led to increased mortality in response to CP infection, characterized by greater numbers of neutrophils and dendritic cells, but no change in the CP burden in the lungs. This was accompanied by an increase in inflammasome-active macrophages and IL-1β production. While induction of autophagy in macrophages led to reduced CP growth in vitro, in vivo treatment with rapamycin led to increased mortality of infected...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
In this study it was assumed that there was no immunity following resolution of natural infection. The modeling demonstrated that a vaccine of moderate efficacy could have a significant impact on the prevalence of gonorrhea if strategically implemented (23). While encouraging it does, of course, depend on the availability of a vaccine. From Ecological Data to Evidence The epidemiological evidence from Cuba, Brazil, and New Zealand demonstrates that N. meningitidis OMV vaccines are possibly able to provide some broader protection against meningococcal disease (17, 24), particularly in older children and adults (25). These...
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
As an obstetrician/gynecologist, I spend my days examining women’s reproductive organs. My patients come to my office with a variety of concerns, some of which can be grouped under the heading of vulvar health. However, many women do not feel comfortable discussing precisely what is bothering them. And rather than use the anatomically correct word — vulva — my patients often tell me, “I have a problem down there.” My job is to figure out what they mean, explain helpful points about vulvar and vaginal health, and empower them to understand their bodies. A look at the anatomy To begin, let&rsquo...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Sexual Conditions Women's Health Source Type: blogs
Source: International Journal of Womens Health - Category: OBGYN Tags: International Journal of Women's Health Source Type: research
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