Protocatechuic Acid Induces Angiogenesis through PI3K‐Akt‐eNOS‐VEGF Signaling Pathway

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Source: Basic and Clinical Pharmacology and Toxicology - Category: Drugs & Pharmacology Authors: Tags: Original Article Source Type: research

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Publication date: Available online 20 November 2019Source: NeuroImage: ClinicalAuthor(s): Lei Gao, Tao Wang, Tianyi Qian, Feng Xiao, Lijun Bai, Junjian Zhang, Haibo XuAbstractSevere (> 70% narrowing) asymptomatic carotid stenosis (SACS) is associated with cognitive impairment and future strokes, and connectivity basis for the remote brain consequences is poorly understood. Here we explored homotopic connectivity and parenchymal lesions measured by multimodal magnetic resonance imaging (MRI) parameters in patients with SACS. Twenty-four patients with SACS (19 males/ 5 females; 64.25 ± 7.18 years), 24 comorbidities...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Publication date: Available online 20 November 2019Source: NeuroImage: ClinicalAuthor(s): Wenjun Hong, Qixiang Lin, Zaixu Cui, Feiwen Liu, Rong Xu, Chaozheng TangAbstractMotor stroke has been characterized by disruptions in multiple large-scale functional brain networks. However, it remains unclear whether stroke patients with good hand outcomes show different connectivity profiles within and between networks from those with poor hand outcomes. In this cross-sectional study, we recruited 52 chronic subcortical stroke patients [illness duration (mean ± SD): 16 ± 16.2 months] and 52 healthy controls from the lo...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
The number and complexity of procedures performed by gastroenterologists are increasing in the United States.1,2 In addition, the number and complexity of antithrombotic agents are growing.3 These concurrent trends may lead to confusion among providers on the  appropriate management of these drugs during endoscopy. The skilled clinician must balance the risks of thrombosis, including myocardial infarction and stroke, against the risks of procedure-related hemorrhage, which can be potentially fatal.
Source: Gastrointestinal Endoscopy - Category: Gastroenterology Authors: Tags: Original article Source Type: research
Conditions:   Stroke;   Balance; Distorted Intervention:   Other: In-patient stroke rehabilitation. Sponsors:   KU Leuven;   Universitaire Ziekenhuizen Leuven Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Spinal Cord Injuries;   Stroke;   Paralysis Intervention:   Device: trans-spinal Electrical Stimulation (tsES) Sponsors:   The Hong Kong Polytechnic University;   University of California, Los Angeles;   Hospital Authority, Hong Kong Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke, Ischemic;   Stroke, Acute Intervention:   Drug: Plasminogen Activators Sponsor:   Ho Chi Minh City University of Medicine and Pharmacy Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Stroke;   Amputation Intervention:   Diagnostic Test: 3D Gait Analysis with Statistical Parametric Mapping Sponsors:   Tan Tock Seng Hospital;   Nanyang Technological University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Funding Opportunity RFA-NS-20-012 from the NIH Guide for Grants and Contracts. This initiative will provide two years of support for planning activities necessary for initiating a Phase III clinical trial designed to validate VCID biomarkers and/or treat patients with VCID. The full spectrum of VCID is in scope, and the one or more VCID disorders(s) to be targeted in the trial must be clearly specified in the application, for example (but not limited to): vascular insults including clinical stroke, silent infarcts and microinfarcts, leukoaraiosis, cerebral amyloid angiopathy (CAA), transient ischemic attack (TIA), micro-b...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
Authors: Hogan C, Binnie MJ, Doyle M, Lester L, Peeling P Abstract PURPOSE: To compare methods of monitoring and prescribing on-water exercise intensity (heart rate [HR], stroke rate [SR], and power output [PO]) during sprint kayak training. METHODS: Twelve well-trained flat-water sprint kayak athletes completed a preliminary on-water 7 × 4-min graded exercise test and a 1000-m time trial to delineate individual training zones for PO, HR, and SR into a 5-zone model (T1-T5). Subsequently, athletes completed 2 repeated trials of an on-water training session, where intensity was prescribed based on individua...
Source: International Journal of Sports Physiology and Performance - Category: Sports Medicine Tags: Int J Sports Physiol Perform Source Type: research
In this study, we reveal that saxagliptin, one of the most widely used DPP-4 inhibitors, exhibits vascular protective effects against oxygen and glucose depletion/reoxygenation (OGD/R) in human brain vascular endothelial cells. Our data show that DPP-4 is fairly expressed in brain endothelial cells and its expression is induced by OGD/R. The results of MTT assay show that inhibition of DPP-4 by saxagliptin ameliorates OGD/R-induced reduced cell viability, and LDH assay demonstrated that saxagliptin reduces cellular toxicity. Furthermore, we show that saxagliptin mitigates OGD/R-induced collapse of mitochondrial membrane po...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
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