Evaluation of Hippocampal Injury and Cognitive Function Induced by Embolization in the Rat Brain

ABSTRACT Embolism is responsible for at least 20% of all stroke and half of cerebral infarctions. A number of animal models have been developed to mimic thromboembolic stroke. However, little aimed directly at hippocampal damage and cognitive function. In the present study, three sizes of emboli (150–178 μm, 74–124 μm, and 48–74 μm) were employed to induce thromboembolic stroke model in rats. Results showed that the diameter of the particle was critical for animal behavioral and histopathological consequences. Hematoxylin–eosin (HE) staining revealed that CA1 and CA2–3, which are two of the main hippocampal subdivisions were injured seriously, especially induced by emboli(48–74 μm). At 24 hr, the neurological deficit scores showed that emboli injection could cause significant neurological deficit, and the increase of neurological deficit scores correlated well to the diameter of emboli. At 60 days, emboli(150–178 μm) and emboli(48–74 μm) lead to obvious cognitive impairment, which correlated well to the hippocampal CA1 injury. Our research might be helpful to choose suitable size of emboli to induce animal model to research subcortical ischemia and vascular dementia. However, cognitive alterations and cerebral injury following different sizes of emboli injection in rats remains a topic for future investigation. Anat Rec, 2013. © 2013 Wiley Periodicals, Inc.
Source: The Anatomical Record Part B: The New Anatomist - Category: Anatomy Authors: Tags: Full Length Article Source Type: research

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Publication date: Available online 20 November 2019Source: NeuroImage: ClinicalAuthor(s): Lei Gao, Tao Wang, Tianyi Qian, Feng Xiao, Lijun Bai, Junjian Zhang, Haibo XuAbstractSevere (> 70% narrowing) asymptomatic carotid stenosis (SACS) is associated with cognitive impairment and future strokes, and connectivity basis for the remote brain consequences is poorly understood. Here we explored homotopic connectivity and parenchymal lesions measured by multimodal magnetic resonance imaging (MRI) parameters in patients with SACS. Twenty-four patients with SACS (19 males/ 5 females; 64.25 ± 7.18 years), 24 comorbidities...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Funding Opportunity RFA-NS-20-012 from the NIH Guide for Grants and Contracts. This initiative will provide two years of support for planning activities necessary for initiating a Phase III clinical trial designed to validate VCID biomarkers and/or treat patients with VCID. The full spectrum of VCID is in scope, and the one or more VCID disorders(s) to be targeted in the trial must be clearly specified in the application, for example (but not limited to): vascular insults including clinical stroke, silent infarcts and microinfarcts, leukoaraiosis, cerebral amyloid angiopathy (CAA), transient ischemic attack (TIA), micro-b...
Source: NIH Funding Opportunities (Notices, PA, RFA) - Category: Research Source Type: funding
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Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Alzheimer's Disease Source Type: news
DiscussionThe aim of this study is to assess the efficacy of tDCS for language/semantic disorders in semantic dementia. A potential treatment would be easily applicable, inexpensive, and renewable when therapeutic effects disappear due to disease progression.Trial registrationClinicalTrials.govNCT03481933. Registered on March 2018.
Source: Trials - Category: Research Source Type: clinical trials
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Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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Source: The Journal of Alzheimers Association - Category: Psychiatry Tags: Alzheimers Dement Source Type: research
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Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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Source: Blood Pressure - Category: Hematology Tags: Blood Press Source Type: research
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Source: Minding Our Elders - Category: Geriatrics Authors: Source Type: blogs
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