Baboon‐Like Syndrome in Children

We describe for the first time baboon syndrome in a child induced by a coinfection with Epstein‐Barr virus and cytomegalovirus.
Source: Pediatric Dermatology - Category: Dermatology Authors: Tags: Case Report Source Type: research

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AbstractCommon infectious agents, such asToxoplasma gondii (T. gondii) and several human herpes viruses, have been linked to increased risk of self-harm. The aim of this study was to investigate the associations between self-harm and seropositivity toT. gondii, Epstein-Barr virus (EBV), Herpes Simplex virus Type 1 (HSV-1), and Cytomegalovirus (CMV). IgM and IgG antibodies to these infections were measured in the Health 2000 project nationally representative of the whole Finnish adult population, and 6250 participants, age 30 and over, were followed for 15  years via registers. In addition, lifetime suicidal ideation a...
Source: European Archives of Psychiatry and Clinical Neuroscience - Category: Neuroscience Source Type: research
Congenital cytomegalovirus (cCMV) infection is a major cause of childhood hearing loss and neurodevelopmental delay. Identification of newborns with cCMV infection allows provision of beneficial interventions. However, most infants with cCMV infection have subclinical infection and go undiagnosed. Thus, expanded neonatal CMV testing is increasingly recommended. Saliva is an attractive sample type for CMV testing of newborns, because it is easier to collect than urine and more sensitive for CMV detection than dried blood spots. We evaluated the Alethia CMV assay, a rapid, easy-to-use loop-mediated isothermal amplification m...
Source: Journal of Clinical Microbiology - Category: Microbiology Authors: Tags: Virology Source Type: research
NK cells are cytotoxic lymphocytes that provide systemic defense against pathogens and malignancy. Although historically considered cells of the innate immune system, NK cells are now known to be capable of memory or memory-like immune responses in certain settings. Memory NK responses were initially reported over a decade ago in studies involving mouse models of cytomegalovirus infection and delayed-type hypersensitivity reactions to chemical haptens and viral antigens. Since then, a growing body of literature suggests that memory or memory-like NK cell responses may occur in a broader range of immunological settings, inc...
Source: Frontiers in cellular and infection microbiology - Category: Microbiology Source Type: research
Publication date: Available online 21 March 2020Source: Antiviral ResearchAuthor(s): Rebecca Böffert, Ramona Businger, Hannes Preiß, Dirk Ehmann, Vincent Truffault, Claudia Simon, Natalia Ruetalo, Klaus Hamprecht, Patrick Müller, Jan Wehkamp, Michael Schindler
Source: Antiviral Therapy - Category: Virology Source Type: research
Future Virology, Ahead of Print.
Source: Future Virology - Category: Virology Authors: Source Type: research
Cytomegalovirus (CMV) is the most commonly transmitted virus in utero with a prevalence of up to 1.5%. The infection has potentially debilitating and devastating consequences for the infected fetus, being a leading cause for neurological disability worldwide. Once acquired, it often goes undetected with only an assumed 10% of infected neonates displaying the classic clinical or imaging features. Viral DNA polymerase chain reaction (PCR) of saliva or urine obtained within the first 21 days of life is required to make the diagnosis.
Source: Clinical Radiology - Category: Radiology Authors: Tags: Review Source Type: research
Publication date: Available online 21 March 2020Source: Brain, Behavior, and ImmunityAuthor(s): Bart N. Ford, T. Kent Teague, Morgan Bayouth, Robert H. Yolken, Jerzy Bodurka, Michael R. Irwin, Martin P. Paulus, Jonathan Savitz
Source: Brain, Behavior, and Immunity - Category: Neurology Source Type: research
The human α-defensin-derived peptide HD5(1-9) inhibits cellular attachment and entry of human cytomegalovirus. Antiviral Res. 2020 Mar 21;:104779 Authors: Böffert R, Businger R, Preiß H, Ehmann D, Truffault V, Simon C, Ruetalo N, Hamprecht K, Müller P, Wehkamp J, Schindler M Abstract Human cytomegalovirus (HCMV) infection causes severe illness in newborns and immunocompromised patients. Since treatment options are limited there is an unmet need for new therapeutic approaches. Defensins are cationic peptides, produced by various human tissues, which serve as antimicrobial effector...
Source: Antiviral Research - Category: Virology Authors: Tags: Antiviral Res Source Type: research
Authors: Wen L, Zhao F, Qiu Y, Cheng S, Sun JY, Fang W, Rayner S, McVoy MA, Jiang XJ, Tang Q, Li FC, Hu F, Luo MH PMID: 32189197 [PubMed - as supplied by publisher]
Source: Protein and Cell - Category: Cytology Tags: Protein Cell Source Type: research
This study aimed at characterizing GCV population PK and interindividual variability (IIV) in intensive care unit (ICU) patients. Secondary objectives were to identify patient characteristics responsible for IIV and simulate GCV exposure for different dosing regimens. Method: In this retrospective observational study, clinical data and serum GCV levels were collected from ICU patients on intravenous GCV. PK modeling, covariate analyses, and explorative Monte Carlo dosing simulations (MCS) were performed using nonlinear mixed-effects modeling. Bootstrap and visual predictive checks were used to determine model adequacy. ...
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
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