MiR-143 and rat embryo implantation.

MiR-143 and rat embryo implantation. Biochim Biophys Acta. 2014 Dec 5; Authors: Tian S, Su X, Qi L, Jin XH, Hu Y, Wang CL, Ma X, Xia HF Abstract Our previous study finds that miR-143 is differentially expressed in rat uteri between pre-receptive and receptive phase via microRNA (miRNA) microarray analysis. However, it is still not clear whether miR-143 play roles during embryo implantation in rat. In the study, we found that the expression level of miR-143 on gestation day 5-8 (g.d. 5-8) was higher than on g.d.3-4 in uteri of pregnant rat. MiR-143 was mainly localized in the superficial stroma/primary decidual zone, luminal and glandular epithelium. The expression of miR-143 was not significantly influenced by pseudopregnancy, but the activation of delayed implantation and experimentally induced decidualization significantly promoted miR-143 expression. Over-expression of miR-143 in human endometrial stromal cells (ESCs) inhibited cell proliferation, migration and invasion Knockdown of miR-143 promoted cell proliferation and invasion. The results of recombinant luciferase reporters showed that miR-143 could bind to the 3'-untranslated region (UTR) of leukemia inhibitory factor receptor (Lifr) to inhibit Lifr translation. These data demonstrate that uterine miR-143 is important for the successful pregnancy, especially during the process of blastocyst implantation. PMID: 25486623 [PubMed - as supplied by publisher]
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Tags: Biochim Biophys Acta Source Type: research

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