MiR-143 and rat embryo implantation.
MiR-143 and rat embryo implantation. Biochim Biophys Acta. 2014 Dec 5; Authors: Tian S, Su X, Qi L, Jin XH, Hu Y, Wang CL, Ma X, Xia HF Abstract Our previous study finds that miR-143 is differentially expressed in rat uteri between pre-receptive and receptive phase via microRNA (miRNA) microarray analysis. However, it is still not clear whether miR-143 play roles during embryo implantation in rat. In the study, we found that the expression level of miR-143 on gestation day 5-8 (g.d. 5-8) was higher than on g.d.3-4 in uteri of pregnant rat. MiR-143 was mainly localized in the superficial stroma/primary decidual zone, luminal and glandular epithelium. The expression of miR-143 was not significantly influenced by pseudopregnancy, but the activation of delayed implantation and experimentally induced decidualization significantly promoted miR-143 expression. Over-expression of miR-143 in human endometrial stromal cells (ESCs) inhibited cell proliferation, migration and invasion Knockdown of miR-143 promoted cell proliferation and invasion. The results of recombinant luciferase reporters showed that miR-143 could bind to the 3'-untranslated region (UTR) of leukemia inhibitory factor receptor (Lifr) to inhibit Lifr translation. These data demonstrate that uterine miR-143 is important for the successful pregnancy, especially during the process of blastocyst implantation. PMID: 25486623 [PubMed - as supplied by publisher]
Semin Reprod Med 2019; 37: 182-190 DOI: 10.1055/s-0039-3400966Several studies provide strong evidence suggesting that in addition to central kisspeptin/KISS1R signaling, the peripheral uterine- and placental-based kisspeptin/KISS1R signaling systems are major regulators of pregnancy. Specifically, the evidence suggests that the uterine-based system regulates embryo implantation and decidualization, while both the uterine- and placental-based systems regulate placentation. Uterine kisspeptin and KISS1R regulate embryo implantation by controlling the availability of endometrial glandular secretions, like leukemia inhibitory ...
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DISCUSSION: Although the clinical significance of variant t(8;21) is not well delineated, the evaluation of 31 such cases suggests patients with variant t(8;21) have similar prognosis to those with classical t(8;21). PMID: 31901918 [PubMed - in process]
A 35-year-old female patient with chronic myeloid leukemia wanted to have a child. She had been treated with imatinib and had achieved major molecular remission, after which imatinib was intentionally discontinued and interferon- α treatment was initiated. After three failed cycles of artificial insemination with her husband’s semen, the patient underwent treatment with assisted reproductive technology. After two cycles ofin vitro fertilization, two embryos (8-cell stage and blastocyst) were cryopreserved. The patient again had elevatedBCR/ABL mRNA levels; thus, infertility treatment was discontinued. After 18 ...
Publication date: Available online 25 December 2019Source: Clinical Lymphoma Myeloma and LeukemiaAuthor(s): Axel Stang, Peter Schwärzler, Susanne Schmidtke, Eva Tolosa, Robin Kobbe
Conclusion: Current evidence from observational studies suggests the association between paternal smoking before conception or during pregnancy and the increased risk of childhood ALL, which needs to be confirmed in prospective studies.
To summarize the published evidence regarding the association between maternal infection during pregnancy and childhood leukemia.
Condition: Acute Leukemia Intervention: Sponsor: University of Hull Recruiting
Leukemia, Published online: 27 November 2019; doi:10.1038/s41375-019-0665-8Maternal exposure to fine particulate matter during pregnancy induces progressive senescence of hematopoietic stem cells under preferential impairment of the bone marrow microenvironment and aids development of myeloproliferative disease