New Treatment Option for Ebola

(Ivanhoe Newswire) -- Many viruses that cause human diseases are non-segmented, negative-strand (NNS) RNA viruses. Some illnesses caused by deadly viruses cannot be treated effectively with existing drugs or vaccines. However, new research reveals several compounds that could inhibit multiple viruses, such as the Ebola virus, along with pathogens responsible for rabies, measles, and mumps, which will open up new therapeutic avenues for combating the pathogenic viruses.
Source: Medical Headlines From - Category: Consumer Health News Source Type: news

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Britain has lost its 'measles free' status after three years of being officially clear of the virus. As many as 231 cases were confirmed in the first quarter of this year.
Source: the Mail online | Health - Category: Consumer Health News Source Type: news
Authors: Hon KL, Leung AKC, Leung K, Chan GCF PMID: 31416996 [PubMed - in process]
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Rebeca T. Steipel, Matthew D. Gallovic, Cole J. Batty, Eric M. Bachelder, Kristy M. AinslieAbstractAlso known as electrospray, electrohydrodynamic atomization has been used extensively in the last 15 years to develop polymer-based particles for drug delivery in cell and animal models. More recently, novel core-shell, multi-axial, and other electrospray particles have been developed from an array of polymers for a variety of biomedical applications. This review focuses on electrospray as a novel method of particle fabrication...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, 13-15-months-old Holstein-Friesian steers were immunised with a subunit vaccine as a prime and a modified vaccinia Ankara vector as a boost, both expressing a chimeric multi-antigen (rMABbo – rMVA). This antigen includes the immunodominant B and T cell epitopes of three B. bovis proteins: merozoite surface antigen - 2c (MSA - 2c), rhoptry associated protein 1 (RAP - 1) and heat shock protein 20 (HSP20). Responses were compared with the Babesia bovis live attenuated vaccine used in Argentina (R1A). Eleven weeks after the first immunisation, all bovines were challenged by the inoculation of a virulent B....
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
In this study, we aimed to elucidate the specific amino acids contributing to S2 epitopes. Site mutagenesis and peptide-based enzyme-linked immunosorbent assays (ELISAs) showed that 16R in S2 protein was a key amino acid mediating the antigenicity of S2 protein. S2-derived peptides with 16R, but not those with 16 K, could react with sera against different types of IBVs. Notably, a commercial ELISA kit for detection of antibodies against IBV did not react with sera against all types of IBVs. Taken together, these data demonstrated that S2-derived peptides with 16R could be used as novel marker-based antigens for deve...
Source: Veterinary Microbiology - Category: Veterinary Research Source Type: research
Publication date: 15 September 2019Source: Life Sciences, Volume 233Author(s): Fatemeh Sadat Tabatabaei Mirakabad, Maryam Sadat Khoramgah, Kamyar Keshavarz F., Maryam Tabarzad, Javad RanjbariAbstractPeptides are oligomers of amino acids, which have been used in a wide range of applications, particularly in medical and pharmaceutical sciences. Linear peptides have been extensively developed in various fields of medicine as therapeutics or targeting agents. The branched structure of peptide dendrimers with peptide (commonly, poly l‑Lysine) or non-peptide (commonly poly‑amidoamine) core, often exhibits valuable novel feat...
Source: Life Sciences - Category: Biology Source Type: research
Publication date: 17 August 2019Source: New Scientist, Volume 243, Issue 3243Author(s): Jessica Hamzelou
Source: New Scientist - Category: Science Source Type: research
Publication date: 17 August 2019Source: New Scientist, Volume 243, Issue 3243Author(s): Ruby Prosser ScullyAs many as 90 per cent of people with the virus could be saved thanks to two experimental drugs, reports Ruby Prosser Scully
Source: New Scientist - Category: Science Source Type: research
Viruses are a frequent cause of encephalitis. Common or important viruses causing encephalitis include herpesviruses, arboviruses, enteroviruses, parechoviruses, mumps, measles, rabies, Ebola, lymphocytic choriomeningitis virus, and henipaviruses. Other viruses may cause an encephalopathy. Host factors and clinical features of infection are important to consider in identifying the cause for encephalitis. Cerebrospinal fluid evaluation, serologic/polymerase chain reaction studies, and neuroimaging are cornerstones of diagnostic evaluation in encephalitis. Treatable forms of encephalitis are important to consider in all case...
Source: Neurologic Clinics - Category: Neurology Authors: Source Type: research
Authors: D'Amelio E, Salemi S, D'Amelio R Abstract A brief history of vaccination is presented since the Jenner's observation, through the first golden age of vaccinology (from Pasteur's era to 1938), the second golden age (from 1940 to 1970), until the current period. In the first golden age, live, such as Bacille Calmette Guérin (BCG), and yellow fever, inactivated, such as typhoid, cholera, plague, and influenza, and subunit vaccines, such as tetanus and diphtheria toxoids, have been developed. In the second golden age, the cell culture technology enabled polio, measles, mumps, and rubella vaccines be dev...
Source: International Reviews of Immunology - Category: Allergy & Immunology Tags: Int Rev Immunol Source Type: research
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