BMJ Analysis: Is an EMA review on hormonal contraception and thrombosis needed?

Source: BMJ Area: News In February 2013, the European Medicines Agency (EMA) announced a review of the safety of combined oral contraceptives, particularly third and fourth generation drugs, including Diane-35(cyproterone acetate 2mg, ethinylestradiol 35mcg) and its generics. The authors of this BMJ Analysis note that third and fourth generation oral contraceptives are overprescribed and that the safest oral contraceptive is one that contains the lowest tolerable dose of ethinylestradiol (lowest dose that prevents breakthrough bleeding; 30mcg) together with the second generation progestogen, levonorgestrel, which is also adequate for the treatment of acne or hirsutism. Therefore, they we can see no reason why lengthy evaluations, let alone new studies, are needed, as there is already sufficient evidence available to recommend the second generation pill with the lowest tolerable oestrogen dose for all indications.
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news

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Strasding, Malin / Sebesty én-Hüvös, Eszter / Studer, Stephan / Lehner, Christian / Jung, Ronald E. / Sailer, IrenaPage 566 - 576Objectives: Long-term retrospective evaluation of the survival rate and the technical and biologic outcomes of all-ceramic inlays and onlays in premolars and molars.Method and materials: Fifty-four patients treated as part of a prospective clinical trial and having received 157 inlays and 27 onlays made out of a leucite-reinforced glass-ceramic (IPS Empress) in premolars and molars, were invited to the present follow-up examination. The survival of the restorations was evaluated....
Source: Quintessence International - Category: Dentistry Source Type: research
Atrial fibrillation is the most common sustained cardiac arrhythmia in the general population. In western countries with aging populations, atrial fibrillation poses a significant health concern, as it is associated with a high risk of thromboembolism, stroke, congestive heart failure, and myocardial infarction. Thrombi are generated in the left atrial appendage, and subsequent embolism into the cerebral circulation is a major cause of ischemic stroke. Therefore, patients have a lifetime risk of stroke, and those at high risk, defined as a CHA2DS2-VASc2 (congestive heart failure, hypertension, age>75 years, diabetes mel...
Source: Cardiology in Review - Category: Cardiology Tags: Review Articles Source Type: research
Authors: Ölçücüo─člu E Abstract AIM: The aim of this study was to compare the complications of laparoscopic simple, radical and donor nephrectomies performed in a single center. MATERIALS AND METHODS: The study was conducted on 392 patients who underwent laparoscopic nephrectomy in University of Health Sciences, Ankara Turkiye Yuksek Ihtisas Training and Research Hospital between January 1, 2008 and January 30, 2019. Clinical and laboratory parameters were recorded. Postoperative complications were recorded and graded as per Clavien-Dindo Classification(CDC). All analyses were performed on...
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
CONCLUSIONS: PNH should be considered during differential diagnosis among patients with idiopathic PVT. Small PNH clones can be detected in PVT patients that we cannot clearly determine its relationship with PVT. We need furthermore studies to explore the potential role of this finding. PMID: 32490645 [PubMed - as supplied by publisher]
Source: Turkish Journal of Medical Sciences - Category: General Medicine Tags: Turk J Med Sci Source Type: research
AbstractPurpose of ReviewThis review discusses the role of aquablation therapy for the treatment of benign prostatic hyperplasia in those with prostate volumes between 80 and 150  mL (WATER II trial).Recent FindingsAquablation therapy reduced International Prostate Symptoms Scores, improved urinary flow rate, and preserved ejaculatory function in the majority of sexually active patients. Other advantages include faster operative times and a shorter learning curve. Adverse events were low and predominantly centered around bleeding risk.SummaryAquablation therapy is effective and safe in the surgical management of large...
Source: Current Bladder Dysfunction Reports - Category: Urology & Nephrology Source Type: research
ConclusionsAdjunctive subgingivally delivered antiseptics with a sustained-release delivery have significant clinical benefits compared to SRP alone.
Source: Dental Technology Blog - Category: Dentistry Source Type: news
Conclusion: Noninvasive HIFU ablation of muscle may not require a coagulation profile within normal limits. PMID: 32491939 [PubMed - as supplied by publisher]
Source: Minimally Invasive Therapy and Allied Technologies - Category: Surgery Tags: Minim Invasive Ther Allied Technol Source Type: research
Reports that COVID-19 is associated with venous and arterial thrombosis and pulmonary embolism and increased rates of thrombosis in cannulae and extracorporeal circuits for renal replacement or membrane oxygenation, have drawn attention to the coagulant effects of the disease.
Source: Current Awareness Service for Health (CASH) - Category: Consumer Health News Source Type: news
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Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
CONCLUSIONS: Ticagrelor monotherapy after 1-month DAPT provided consistent treatment effects on ischemic endpoints in patients with or without ACS but only the former experienced a net clinical benefit. Trial registration ClinicalTrials.gov number NCT03231059. PMID: 32482616 [PubMed - as supplied by publisher]
Source: EuroIntervention - Category: Cardiovascular & Thoracic Surgery Tags: EuroIntervention Source Type: research
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