Effect of platelet inhibition with cangrelor during PCI on ischaemic events

Source: New England Journal of Medicine Area: News The findings of a study evaluating whether cangrelor reduces ischaemic complications of percutaneous coronary intervention (PCI) have been presented at the meeting of the American College of Cardiology and published early online in the New England Journal of Medicine.   The authors note that thrombotic complications during PCI remain a major concern, despite advances in adjunctive pharmacotherapy. Although platelet adenosine diphosphate (ADP) P2Y12 inhibitors reduce the risk of ischaemic events, particularly stent thrombosis, only oral agents are currently available, and patients in the acute phase of cardiovascular illness may have conditions that limit drug availability. Sources of variation in the pharmacokinetic and pharmacodynamic response to clopidogrel have also been described. Glycoprotein IIb/IIIa inhibitors are effective but their effects last for hours and cannot be easily reversed.   Cangrelor is a fast-acting, rapidly reversible intravenous ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news

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To determine, in patients with acute coronary syndromes (ACS) or undergoing percutaneous coronary intervention (PCI), the effectiveness and safety between personalized P2Y12 inhibitors treatment based on genotypes and standard treatment.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Review Article Source Type: research
To mitigate the risk of stent thrombosis, patients treated by percutaneous coronary intervention (PCI) are administered dual anti-platelet therapy comprising aspirin and a platelet P2Y12 receptor inhibitor. Clopi...
Source: BMC Cardiovascular Disorders - Category: Cardiology Authors: Tags: Study protocol Source Type: research
Left ventricular thrombosis (LVT) is a potentially devastating complication in post-acute myocardial infarction (AMI) patients. Previous studies have demonstrated that inflammation may contribute to thrombus formation, but its role on thrombus resolution is uncertain. The neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) are easily accessible haematological markers of inflammation.
Source: Thrombosis Research - Category: Hematology Authors: Tags: Full Length Article Source Type: research
ConclusionsIn patients with LM bifurcation disease, single stent strategy demonstrated lower rate of MACEs and TLR but was not superior to 2-stent strategy in terms of CV mortality, TLF and ST at 1 and 3-year follow-up.Graphic abstract
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
In conclusion, low-dose intracoronary urokinase during primary PCI is associated with a more favourable 5-year outcome of patients with STEMI.
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
CONCLUSIONS: ACS patients with DM showed weaker coronary plaque regression than their counterparts. A significant correlation between the change in LDL-C level and ΔPAV in DM patients suggested that more intensive lipid-lowering therapy is required in ACS patients with DM. PMID: 32435011 [PubMed - as supplied by publisher]
Source: Journal of Atherosclerosis and Thrombosis - Category: Cardiology Tags: J Atheroscler Thromb Source Type: research
Conclusion: Routine use of VN assay in personalized antiplatelet treatment decision-making after PCI is associated with lower likelihood of using novel P2Y12 inhibitors. PMID: 32368161 [PubMed]
Source: Clinical Pharmacology: Advances and Applications - Category: Allergy & Immunology Tags: Clin Pharmacol Source Type: research
This article reviews current evidence and focuses on the optimal approach to antithrombotic treatment in patients with AF undergoing PCI in acute and chronic/stable phases. PMID: 32389534 [PubMed - as supplied by publisher]
Source: Journal of Cardiology - Category: Cardiology Authors: Tags: J Cardiol Source Type: research
Abstract Coronavirus disease 2019 (COVID-19) is a recently recognised pandemic spreading rapidly from Wuhan, Hubei, to other provinces in China and to many countries around the world. The number of COVID-19-related deaths is steadily increasing. Acute ST-segment elevation myocardial infarction (STEMI) is a disease with high morbidity and mortality rates, and primary percutaneous coronary intervention is usually recommended for the treatment. A patient with diabetes mellitus and hypertension for five years was admitted to the emergency unit with symptoms of fever, cough and dyspnoea. These symptoms were consistent ...
Source: Cardiovascular Journal of Africa - Category: Cardiology Authors: Tags: Cardiovasc J Afr Source Type: research
Background Despite recent improvements in percutaneous coronary revascularization and antithrombotic therapies for the treatment of acute coronary syndromes, the outcome is still unsatisfactory in high-risk patients, such as the elderly and patients with diabetes. The aim of the current study was to investigate the prognostic impact of diabetes on clinical outcome among patients included in the Elderly-ACS 2 trial, a randomized, open-label, blinded endpoint study carried out at 32 centers in Italy. Methods Our population is represented by 1443 patients included in the Elderly-ACS 2 trial. Diabetes was defined as known...
Source: Journal of Cardiovascular Medicine - Category: Cardiology Tags: Research articles: Coronary artery disease Source Type: research
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