Systematic review and meta-analysis of new oral anticoagulants in addition to single or dual antiplatelet therapy after an acute coronary syndrome

Source: European Heart Journal Area: News Oral vitamin K antagonists have been shown to prevent recurrent ischaemic events after acute coronary syndrome (ACS), both as mono-therapy and in combination with aspirin, but substantially increase bleeding. The potential of new oral anticoagulants as antithrombotic therapy after ACSs has been investigated over the past few years and consistent increases in bleeding and the less consistent reduction in ischaemic events have been reported. The overall benefit-risk profile of adding new oral anticoagulants to antiplatelet treatment after an ACS is unknown.   This meta-analysis evaluated the efficacy and safety of adding direct thrombin or factor-Xa inhibition by any of the novel oral anticoagulants (apixaban, dabigatran, darexaban, rivaroxaban, and ximelagatran) to single (aspirin) or dual (aspirin and clopidogrel) antiplatelet therapy in this setting.   Seven published randomised, placebo-controlled phase II and III studies of novel oral anticoagulants in ACS ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news

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This study, for instance, attributes a patient’s waitlist/transplant outcome to the very last dialysis facility the patient was associated with.  In epidemiology speak, this means the causal inference authors are trying to draw between for-profit status and good transplant outcomes is subject to time-varying confounding. As an example, if one is seeking an association between testosterone levels and risk of a heart attack, using the last testosterone level available would be a poor way of doing this study because testosterone levels are known to vary over time. The same applies to dialysis facilities. Patie...
Source: The Health Care Blog - Category: Consumer Health News Authors: Tags: Medical Practice Physicians Eric Weinhandl JAMA medical research public health Public Policy public policy research Source Type: blogs
Abstract Dietary supplements (DS) pose many side effects and multiple interactions with perioperative medications, which may increase surgical morbidity and mortality. Descriptive empirical data are essentially nonexistent related to DS consumption and patient knowledge of DS. The aims of this study were to investigate the prevalence of use, type of supplements used, and the knowledge base among military beneficiaries and veterans consuming DS during the preoperative period. This descriptive cross-sectional study solicited data from 2,623 volunteer, preoperative patients at 6 different military medical centers thr...
Source: AANA Journal - Category: Anesthesiology Authors: Tags: AANA J Source Type: research
ConclusionAfter great improvements in rectal cancer treatment, late gastrointestinal toxicity after radiotherapy is experienced less frequent and less severe; however, it remains a great concern associated with worse quality of life.
Source: International Journal of Colorectal Disease - Category: Gastroenterology Source Type: research
ConclusionIt is safe to continue the use of anti-platelet therapy throughout the peri-operative phase in patients with hip fracture surgery. The continuation of such therapy is not associated with increased risk of bleeding or blood transfusion or other complications in patients who had surgical treatment for femoral neck fracture.
Source: International Orthopaedics - Category: Orthopaedics Source Type: research
Authors: Wheeler AP, Hemingway C, Gailani D Abstract INTRODUCTION: Factor XI (FXI) deficiency is associated with highly variable bleeding, including excessive gynecologic and obstetrical bleeding. Since approximately 20% of FXI-deficient women will experience pregnancy-related bleeding, careful planning and knowledge of appropriate hemostatic management is pivotal for their care. AREAS COVERED: In this manuscript, authors present our current understanding of the role of FXI in hemostasis, the nature of the bleeding phenotype caused by its deficiency, and the impact of deficiency on obstetrical care. The authors...
Source: Expert Review of Hematology - Category: Hematology Tags: Expert Rev Hematol Source Type: research
Authors: Merideth MA, Introne WJ, Wang JA, O'Brien KJ, Huizing M, Gochuico BR Abstract Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder characterized by defective biogenesis of lysosome-related organelles. Clinical manifestations include a bleeding diathesis due to a platelet delta storage pool deficiency, oculocutaneous albinism, inflammatory bowel disease, neutropenia, and pulmonary fibrosis. Ten genes associated with HPS are identified to date, and each gene encodes a protein subunit of either Biogenesis of Lysosome-related Organelles Complex (BLOC)-1, BLOC-2, BLOC-3, or the Adaptor Protein...
Source: Platelets - Category: Hematology Tags: Platelets Source Type: research
Publication date: Available online 22 May 2020Source: Journal of Pediatric Surgery Case ReportsAuthor(s): Ryo Tamura, Corina Moldovan, Milan Gopal
Source: Journal of Pediatric Surgery Case Reports - Category: Surgery Source Type: research
Conclusion Complete removal of the axillary scar tissue after breast cancer treatment and re-augmentation of the axilla with a turnover flap results in a reduction in ipsilateral lymphedema and an improvement in pain and quality of life. We interpret these findings as a result of the physiological re-alignment of the lymphatic vessels combined with a lymph node-containing local transposition flap. Therefore, re-augmentation with a turnover flap could be an effective non-microsurgical alternative to lymph node transplantation. PMID: 32435069 [PubMed]
Source: Geburtshilfe und Frauenheilkunde - Category: OBGYN Tags: Geburtshilfe Frauenheilkd Source Type: research
AbstractPurposeWe aimed to investigate the association between sleep disturbance and menstrual problems in female Chinese university students.MethodsA convenience sample of 1006 female university students participated in this study. Sleep duration, sleep quality, and insomnia symptoms were assessed by the Pittsburgh Sleep Quality Index and the Insomnia Severity Index. A structured questionnaire was used to assess participants ’ demographics and menstrual characteristics.ResultsThe prevalence rates of irregular menstrual cycle, heavy menstrual bleeding, menstrual flow length ≥ 7 days, period pain, and p...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
CONCLUSIONS: Results from this PMS increase the clinical experience of a FVIII-poor pdVWF in patients of all ages and VWD types including those with thrombotic risk factors and emphasize that giving FVIII is not always mandatory to effectively treat patients with severe VWD. PMID: 32445594 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: J Thromb Haemost Source Type: research
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