Effect of antioxidant vitamin supplementation on cardiovascular outcomes: A meta-analysis of randomised controlled trials

Source: PLoS One Area: News According to the findings of this systematic review and meta-analysis of pooled data from randomised controlled trials (RCTs), antioxidant vitamin supplementation has no effect on the incidence of major cardiovascular events, myocardial infarction, stroke, total death, and cardiac death.   Data (published and unpublished) for the analysis were sourced through a search of databases such as PubMed, EmBase the Cochrane Central Register of Controlled Trials and conference reports. Studies were included if they were RCTs that reported on the effects of antioxidant vitamins on cardiovascular outcomes vs.  placebo. Overall a total of 293 studies were identified and of these 15 trials were included in the analysis (n=188,209). Of the RCTs included, 7 trials evaluated antioxidant vitamin supplementation in participants with high cardiovascular risk factors or previous cardiovascular disease, and the remaining 8 trials reported individuals without high cardiovascular risk ...
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news

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CONCLUSION: As an easily accessible parameter, WBV might be a useful predictor of LVT formation within one year following acute anterior myocardial infarction. PMID: 32444531 [PubMed - as supplied by publisher]
Source: Biorheology - Category: Biochemistry Tags: Biorheology Source Type: research
CONCLUSION: For patients with ULMCA disease and LVSD, there was no significant difference between DES and CABG in terms of efficacy and safety. Treatment with DES was an acceptable alternative to CABG. PMID: 32435839 [PubMed - as supplied by publisher]
Source: Herz - Category: Cardiology Tags: Herz Source Type: research
A significant amount of clinical and research interest in thrombosis is focused on large vessels (e.g., stroke, myocardial infarction, deep venous thrombosis, etc.); however, thrombosis is often present in the microcirculation in a variety of significant human diseases, such as disseminated intravascular coagulation, thrombotic microangiopathy, sickle cell disease, and others. Further, microvascular thrombosis has recently been demonstrated in patients with COVID-19, and has been proposed to mediate the pathogenesis of organ injury in this disease.
Source: Translational Research - Category: Research Authors: Tags: Review Article Source Type: research
DiscussionDANBLOCK is a randomized clinical trial investigating the effect of long-term beta-blocker therapy after myocardial infarction in patients without heart failure and reduced LVEF. Results from the trial will add important scientific evidence to inform future clinical guidelines.Trial registrationClinicaltrials.gov,NCT03778554. Registered on 19 December 2018.European Clinical Trials Database,2018-002699-42, registered on 28 September 2018.
Source: Trials - Category: Research Source Type: clinical trials
FRIDAY, May 22, 2020 (American Heart Association News) -- High blood pressure is one of the top risk factors for heart attack and stroke. It's also common among people who develop severe symptoms of COVID-19. So, with more people at home practicing...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Title: AHA News: After Diabetes, Stroke and Heart Attack, She's Learning to'Fight Smart 'Category: Health NewsCreated: 5/21/2020 12:00:00 AMLast Editorial Review: 5/22/2020 12:00:00 AM
Source: MedicineNet Heart General - Category: Cardiology Source Type: news
CONCLUSIONS: In patients with kidney failure and nonvalvular atrial fibrillation, treatment with apixaban was not associated with a lower incidence of new stroke, transient ischemic attack, or systemic thromboembolism but was associated with a higher incidence of fatal or intracranial bleeding. PMID: 32444398 [PubMed - as supplied by publisher]
Source: Clinical Journal of the American Society of Nephrology : CJASN - Category: Urology & Nephrology Authors: Tags: Clin J Am Soc Nephrol Source Type: research
AbstractThe coronary artery calcium data and reporting system (CAC-DRS) is a novel reporting system based on CAC severity. Lung cancer patients have a high risk of cardiovascular disease (CVD), for which CAC severity may provide additional prognostic information. Using non-gated, non-contrast computed tomography (CT), we evaluated the CAC-DRS for predicting CVD and all-cause death in patients with potentially curable resected lung cancer. We retrospectively studied 309 consecutive patients without a history of CVD (mean age 67.4  ± 8.2 years, 61% male) who underwent curative surgery for non-small-...
Source: Heart and Vessels - Category: Cardiology Source Type: research
THURSDAY, May 21, 2020 (American Heart Association News) -- Hyvelle Ferguson-Davis was reviewing paperwork at her office in Fort Lauderdale, Florida, when the headache started. It grew stronger and stronger and her eyes blurred, making it difficult...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Abstract Peripheral artery disease is a common disorder and a major cause of morbidity and mortality worldwide. Therapy is directed at reducing the risk of major adverse cardiovascular events and at ameliorating symptoms. Medical therapy is effective at reducing the incidence of myocardial infarction and stroke to which these patients are prone but is inadequate in relieving limb-related symptoms, such as intermittent claudication, rest pain, and ischemic ulceration. Limb-related morbidity is best addressed with surgical and endovascular interventions that restore perfusion. Current medical therapies have only mod...
Source: Arteriosclerosis, Thrombosis and Vascular Biology - Category: Cardiology Authors: Tags: Arterioscler Thromb Vasc Biol Source Type: research
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