Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke

Certain types of iron oxide nanoparticles are not suited to passively target inflammatory cells that infiltrate the brain in response to stroke Journal of Cerebral Blood Flow &Metabolism advance online publication, February 27 2013. doi:10.1038/jcbfm.2013.22 Authors: Christoph Harms, Anna Lena Datwyler, Frank Wiekhorst, Lutz Trahms, Randall Lindquist, Eyk Schellenberger, Susanne Mueller, Gunnar Schütz, Farnoosh Roohi, Andreas Ide, Martina Füchtemeier, Karen Gertz, Golo Kronenberg, Ulrike Harms, Matthias Endres, Ulrich Dirnagl &Tracy D Farr
Source: Journal of Cerebral Blood Flow - Category: Neurology Authors: Tags: inflammation iron oxide nanoparticles magnetic resonance imaging stroke Source Type: research

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ConclusionsTwenty-and-a-half syndrome is reported for the first time. It is due to posterior circulation stroke; in our case, it was due to lacunar infarcts in the pons and medulla, manifesting as one-and-a-half syndrome with bilateral seventh and right fifth nerve palsy.
Source: Journal of Medical Case Reports - Category: General Medicine Source Type: research
Conclusions: VBA stenosis or occlusion was relatively prevalent among patients with TIA or ischemic stroke and associated with higher risk of recurrent stroke and death in patients with ischemic stroke or TIA who had large artery atherosclerosis.Cerebrovasc Dis 2019;47:40 –47
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
Abstract BACKGROUND: Perinatal stroke is a potentially debilitating injury, often under-diagnosed in the neonatal period. We conducted a pilot study investigating the role of the portable, non-invasive brain monitoring technique, diffuse optical tomography (DOT), as an early detection tool for infants with perinatal stroke. METHODS: Four stroke-affected infants were scanned with a DOT system within the first 3 days of life and compared to four healthy control subjects. Spectral power, correlation, and phase lag between interhemispheric low frequency (0.0055-0.3 Hz) hemoglobin signals were assessed. Opt...
Source: Pediatric Research - Category: Pediatrics Authors: Tags: Pediatr Res Source Type: research
Conditions:   Stroke;   Cerebral Venous System;   Reperfusion Injury Intervention:   Radiation: multimodal magnetic resonance imaging or computed tomography Sponsor:   Second Affiliated Hospital, School of Medicine, Zhejiang University Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
This study aimed to evaluate the burden of leukoaraiosis, a marker of cerebral SVD, and hippocampal atrophy in patients with late-onset epilepsy (LOE).MethodsBrain magnetic resonance imaging (MRI) studies were retrospectively analyzed by two blinded radiologists. The Fazekas and Scheltens scales were used to assess the degree of leukoaraiosis and hippocampal atrophy in 33 patients with non-lesional LOE, 41 patients with clinical signs of SVD (eg, recent history of transient ischemic attack [TIA] or lacunar stroke), and 26 healthy controls, all>60 years of age.ResultsMean age in epilepsy patients was 70.9 (±6.6) y...
Source: Seizure - Category: Neurology Source Type: research
A 2-year-old girl was evaluated following a fall from a scooter ’s footrest. The physical examination revealed right side upper motor neuron facial palsy and ipsilateral hemiplegia. Magnetic resonance imaging (MRI) of the brain revealed acute infarction of the left gangliocapsular region (Figure 1). Computed tomography of the head (HCT) revealed bilateral basa l ganglia calcifications, and a hypodensity over the left gangliocapsular region (Figure - panel B). Coronal and sagittal reconstruction HCT images revealed bilateral linear calcifications suggestive of mineralized lenticulostriate arteries (Figure - panels C, D).
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Visual Diagnosis Source Type: research
Authors: Han X, Bai L, Sun C, Niu X, Ning Y, Chen Z, Li Y, Li K, Lyu D, Fu C, Cui F, Chen Z, Tan Z, Tang L, Zou Y Abstract Stroke is a leading cause of motor disability. Acupuncture is an effective therapeutic strategy for poststroke motor impairment. However, its mechanism is still elusive. Twenty-two stroke patients having a right-hemispheric subcortical infarct and 22 matched healthy controls were recruited to undergo diffusion tensor imaging (DTI) and functional magnetic resonance imaging (fMRI) scanning. The resting-state fMRI was implemented before and after needling at GB34 (Yanglingquan). The stroke patient...
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Abstract Carotid and intracranial imaging play an essential role in the comprehensive evaluation and prevention for stroke patients. High-resolution vessel wall magnetic resonance imaging (HR VW-MRI) has been applied in carotid and intracranial arteries with optimal ability in displaying the features of various vascular diseases. Recent advanced MRI techniques can not only help in the differential diagnosis of vascular diseases but can also provide information on pathogenesis exploration of underlying mechanisms, follow-up monitoring, and determination of prognosis for patients with cerebral strokes. The aim of th...
Source: Acta Radiologica - Category: Radiology Authors: Tags: Acta Radiol Source Type: research
Publication date: Available online 4 February 2019Source: Journal of Clinical NeuroscienceAuthor(s): Kiyofumi Yamada, Shinichi Yoshimura, Manabu Shirakawa, Kazutaka Uchida, Shigehiro Nakahara, Shuji Nishida, Yasuhiro Iwamoto, Yoshikazu Sato, Masanori KawasakiAbstractCarotid intraplaque hemorrhage (IPH) plays a critical role in the progression of carotid atherosclerotic disease. IPH was associated with high intensity signal (HIS) in the plaque on Maximum intensity projection (MIP) images from routine three dimensional magnetic resonance imaging (3D-TOF MRA). The aim of this study was to evaluate the relationships among HIS,...
Source: Journal of Clinical Neuroscience - Category: Neuroscience Source Type: research
We report a case of a 58-year-old male who presented with stroke-like episodes and late-onset mitochondrial encephalopathy. Brain magnetic resonance imaging (MRI) revealed multiple lesions in different locations, including in the left hypothalamus, bilateral parietal lobe, left occipital lobe, centrum semiovale and right cerebellar hemisphere. Muscle histopathological analysis showed no myopathic changes. We identified a T14487C mutation in the mitochondrial DNA (mtDNA), which causes a M63V substitution in the mitochondrial NADH dehydrogenase 6 (ND6) of complex I of the mitochondrial respiratory chain. The mutation was het...
Source: Chinese Medical Journal - Category: General Medicine Authors: Tags: Chin Med J (Engl) Source Type: research
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