NICE costing statement for its guidance on apixaban for prevention of stroke and systemic embolism in non-valvular atrial fibrillation (TA 275)

Source: NICE Area: News NICE has published a costing statement to accompany its guidance on the use of apixaban for preventing stroke and systemic embolism in nonvalvular atrial fibrillation (TA 275).   The statement notes that "Apixaban provides an alternative treatment option at a comparable cost and therefore it is anticipated that there will not be a significant cost impact as a result of implementing this guidance."
Source: NeLM - Cardiovascular Medicine - Category: Cardiology Source Type: news

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Publication date: Available online 14 February 2019Source: American Journal of Kidney DiseasesAuthor(s):
Source: American Journal of Kidney Diseases - Category: Urology & Nephrology Source Type: research
ConclusionBetween 2011 and 2016, the use of guideline-conform antithrombotic therapy in Germany has significantly increased. This was associated with a significant decline in strokes without an increased incidence of bleeding complications.
Source: Clinical Research in Cardiology - Category: Cardiology Source Type: research
Direct oral anticoagulants (DOACs) reduce the risk of stroke and systemic embolism in patients with non-valvular atrial fibrillation but may result in serious bleeding complications. Off-label dose-reduced use of DOAC to mitigate bleeding is common in routine clinical practice although data regarding its consequences on patient outcomes is limited. Therefore, our objective was to evaluate the effectiveness and safety of off-label dose-reduced versus per-label standard-dose DOAC treatment.
Source: The American Journal of Medicine - Category: General Medicine Authors: Source Type: research
THURSDAY, Feb. 14, 2019 -- Many older Americans are diagnosed with the irregular heartbeat known as atrial fibrillation, or " a-fib. " Now, research suggests that everyday foods, drinks or activities might trigger episodes of the stroke-linked...
Source: Drugs.com - Daily MedNews - Category: General Medicine Source Type: news
Obesity has been linked with increased incidence of atrial fibrillation (AF), but impact of presence of obesity on outcomes of hospitalizations for AF has not been investigated. We used the National Inpatient Sample (NIS) database 2010-2014 to identify all adult hospitalizations aged ≥18 years with a primary diagnosis of AF. Obese patients were identified using the co-morbidity variable for obesity, as defined in NIS databases. Multivariable logistic regression was used to compare in-hospital outcomes (mortality, acute stroke events) between obese and non-obese patients with A F.
Source: The American Journal of Cardiology - Category: Cardiology Authors: Source Type: research
This study aimed to evaluate whether gray zone AF patients could benefit from reduced all-cause mortality under antithrombotic treatment. This was a longitudinal cohort study performed using data from claim forms submitted to the Taiwan Bureau of National Health Insurance from January 2000 to December 2011. The new-onset AF patients consisted of a gray zone cohort with a total of 1237 patients being enrolled. The primary outcome was all-cause mortality between 2001 and 2011. Patients in the gray zone receiving antithrombotic treatment had a significant reduction in all-cause mortality [hazard ratio (HR): 0.21; 95% confiden...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Atrial fibrillation (AF) is one of the most prevalent sustained arrhythmias, however, epidemiological data may understate its actual prevalence. Meanwhile, AF is considered to be a major cause of ischemic stro...
Source: Journal of Translational Medicine - Category: Research Authors: Tags: Research Source Type: research
Abstract PMID: 30759487 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
Atrial fibrillation is common in patients with congestive heart failure (CHF). Due to reduced left atrial appendage (LAA) emptying velocities and increased sludge formation, a higher rate of stroke and embolism are seen with CHF. Up to 50% of CHF patients are inadequately covered for stroke protection with anticoagulation, and, even while on therapy, CHF patients are at risk for failure to clear LAA or left ventricular (LV) thrombus. Device-based LAA closure (LAAC) alternatives exist. Following intracardiac device closure, an increased rate of device-related thrombus is seen in heart failure patients, which warrants furthe...
Source: Cardiology Clinics - Category: Cardiology Authors: Source Type: research
Atrial fibrillation (AF) is present in 15 –20% of patients with acute ischemic stroke. Oral anticoagulation reduces the risk of AF-related recurrent stroke but clinical guideline recommendations are rather vagu...
Source: BMC Neurology - Category: Neurology Authors: Tags: Research article Source Type: research
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