Immunohistochemical detection of mutations in the epidermal growth factor receptor gene in lung adenocarcinomas using mutation-specific antibodies
Conclusions: Our data demonstrate that mutation-specific IHC, using optimized procedures, is a reliableprescreening test for detecting EGFR mutations in lung adenocarcinoma.Virtual SlidesThe virtual slide(s) for this article can be found here:http://www.diagnosticpathology.diagnomx.eu/vs/2059012601872392
CONCLUSIONUsing 3D-MDCT, we could accurately divide A4 + 5 and safely perform the surgery.
Introduction: Dermatomyositis (DM) is an idiopathic inflammatory myopathy that presents with proximal muscle weakness accompanied by a characteristic rash. The relationship between DM and malignancy is well established in the literature, with malignancy identified in approximately 25% of cases of DM. The most commonly associated malignancies are ovarian, lung, gastric, pancreatic and bladder adenocarcinomas. The presence of transcriptional intermediary factor 1- γ (TIF1-γ) autoantibodies in patients with DM is associated with higher rates of malignancy than those without the autoantibody.
We present the case of a patient with paraneoplastic acral vascular syndrome as an initial manifestation of lung cancer.
We describe the case of a 61-year-old male recently diagnosed with poorly differentiated esophageal adenocarcinoma. Dermatology was consulted for the evaluation of multiple, enlarging painful skin nodules concerning for cutaneous metastases. On physical examination, firm, indurated, minimally mobile subcutaneous nodules were present on the scalp, left cheek, back, abdomen, hands, and right thigh.
We present a case of a 59-year old male with a medical history of cardiovascular disease, history of untreated esophageal adenocarcinoma, depression, anxiety, and alcohol abuse who presented to our clinic with a new-onset photodistributed eruption and progressive periorbital edema. He was previously seen by his primary care physician for periorbital edema that was associated with ocular pain and was treated for presumed diagnosis of preseptal cellulitis. His symptoms continued to progress at which point he was thought to have angioedema secondary to lisinopril prompting discontinuation of this medication.
Background: Apocrine adenocarcinoma of the eyelid is a rare sweat gland cancer with potential for metastasis. It can have similar clinical presentation to other eyelid lesions, such as a chalazion. Management is based on recommendations from reported cases. Surgical excision is considered effective in apocrine adenocarcinoma of the eyelid.
Although rare, the Sister Mary Joseph Nodule is considered the most common presentation of cutaneous metastatic gastrointestinal adenocarcinoma, arising as a solitary umbilical nodule. This case represents an example of atypical, nonumbilical, metastatic pancreaticobiliary adenocarcinoma, ominously disguised as more innocuous lesions on the extremities. A 63-year-old Caucasian female with discoid lupus was referred for a 6-week history of subcutaneous nodules on the extremities. She described a long history of lipomas but noted that the current lesions were distinctly tender.
We present an unusual case of cutaneous CMV presenting as ulcerations on the anterior thigh of a 57-year-old female, in whom the only source of immunosuppression was a recent 1-month course of dexamethasone for metastatic lung adenocarcinoma. The patient was hospitalized for treatment of pneumocystis and cytomegalovirus pneumonias. The left thigh lesions had begun one week prior as erythematous macules that progressed into tender ulcerations.
Skin metastases occur in 0.6-10.4% of patients with cancer, represent 2% of all skin tumors, and generally indicate a poor prognosis with an average survival time of under one year. Cutaneous metastases of ovarian cancer commonly are localized in the vicinity of the primary tumor secondary to spreading from the adjacent peritoneum or arising in abdominal incisional scars. Scalp and extremity lesions are rarely reported. Our now 33-year-old female patient was diagnosed with Stage IIIC low-grade serous papillary ovarian adenocarcinoma in 2010.
Condition: Prostatic Adenocarcinoma Intervention: Sponsor: University Hospital, Brest Recruiting