CHMP recommends approval of ocriplasmin (Jetrea®) for vitreomacular traction

Source: European Medicines Agency Area: News The Committee for Medicinal Products for Human Use (CHMP) has recommended the granting of a marketing authorisation for ocriplasmin (Jetrea®) for the treatment of vitreomacular traction (VMT), including when associated with macular hole of diameter ?400 microns. VMT is an age-related progressive, sight-threatening condition that may lead to visual distortion, decreased visual acuity and central blindness. It is estimated to affect between 250,000 to 300,000 patients in Europe.   Ocriplasmin is a recombinant form of human plasmin, administered as a single intravitreal injection. It targets the protein fibres which cause the abnormal pulling between vitreous and macula that causes VMT. By dissolving these proteins, ocriplasmin releases the traction, and helps to complete the detachment of the vitreous from the macula. It may therefore prevent further damage to the vision and a need for vitrectomy in a small percentage of patients. The most common side effects include ...
Source: NeLM - News - Category: Drugs & Pharmacology Source Type: news

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Source: bizjournals.com Health Care:Physician Practices headlines - Category: American Health Authors: Source Type: news
CONCLUSIONS: Results of our study support the hypothesis that D-allele and DD-genotype of rs35569394 have deleterious effect on the progression of DR. C-allele had skewed frequency towards DR III subjects owing to strong linkage disequilibrium between C-allele (rs699947) and D-allele (rs35569394).PMID:34693874 | DOI:10.1080/13816810.2021.1992786
Source: Ophthalmic Genetics - Category: Opthalmology Authors: Source Type: research
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Source: Journal of Immunology Research - Category: Allergy & Immunology Authors: Source Type: research
Age-related macular degeneration (AMD) is a leading cause of blindness. Late AMD can be classified into exudative (commonly known as wet AMD [wAMD]) or dry AMD, both of which may progress to macular atrophy (MA). MA causes irreversible vision loss and currently has no approved pharmacological treatment. The standard of care for wAMD is treatment with anti-vascular endothelial growth factors (VEGF). However, recent evidence suggests that anti-VEGF treatment may play a role in the development of MA. Therefore, it is important to identify risk factors for the development of MA in patients with wAMD. For example, excessive blo...
Source: Ophthalmologica - Category: Opthalmology Source Type: research
Stefania Galdiero HSV infections, both type 1 and type 2, are among the most widespread viral diseases affecting people of all ages. Their symptoms could be mild, with cold sores up to 10 days of infection, blindness and encephalitis caused by HSV-1 affecting immunocompetent and immunosuppressed individuals. The severe effects derive from co-evolution with the host, resulting in immune evasion mechanisms, including latency and growing resistance to acyclovir and derivatives. An efficient alternative to controlling the spreading of HSV mutations is the exploitation of new drugs, and the possibility of enhancing their ...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Exp Eye Res. 2021 Oct 21:108800. doi: 10.1016/j.exer.2021.108800. Online ahead of print.ABSTRACTAging is a predominant risk factor for various eye diseases. Age-related macular degeneration (AMD) is the leading cause of blindness in the elderly, and its etiology remains unclear. Fragmented and dysfunctional mitochondria are associated with age-related diseases. The retinal pigment epithelium (RPE), a polarized cell layer that functions in visual pigment recycling and degeneration, is suspected as the primary region site of AMD. In the present study, we investigated the relationship between mitochondrial dysfunction and RPE...
Source: Cell Research - Category: Cytology Authors: Source Type: research
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Source: Daily Express - Health - Category: Consumer Health News Source Type: news
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Source: Journal of the American College of Surgeons - Category: Surgery Authors: Tags: Plastic and Maxillofacial Surgery Source Type: research
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Source: Proceedings of the National Academy of Sciences - Category: Science Authors: Tags: Medical Sciences Biological Sciences Source Type: research
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Source: The European Journal of Public Health - Category: General Medicine Source Type: research
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