Low-power laser may keep blindness at bay

A promising laser treatment, which works in a mysterious way, is shaking up our understanding of a major cause of vision loss in the West
Source: New Scientist - Health - Category: Consumer Health News Source Type: research

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Conditions:   Blindness;   Implicit Bias Intervention:   Sponsor:   University of Haifa Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Biomed Pharmacother. 2021 Nov 30;145:112472. doi: 10.1016/j.biopha.2021.112472. Online ahead of print.ABSTRACTMyopia has become one of the most critical health problems in the world with the increasing time spent indoors and increasing close work. Pathological myopia may have multiple complications, such as myopic macular degeneration, retinal detachment, cataracts, open-angle glaucoma, and severe cases that can cause blindness. Mounting evidence suggests that the cause of myopia can be attributed to the complex interaction of environmental exposure and genetic susceptibility. An increasing number of researchers have focus...
Source: Biomedicine and pharmacotherapy = Biomedecine and pharmacotherapie - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractAchromatopsia (ACHM), also known as rod monochromatism or total color blindness, is an autosomal recessively inherited retinal disorder that affects the cones of the retina, the type of photoreceptors responsible for high-acuity daylight vision. ACHM is caused by pathogenic variants in one of six cone photoreceptor-expressed genes. These mutations result in a functional loss and a slow progressive degeneration of cone photoreceptors. The loss of cone photoreceptor function manifests at birth or early in childhood and results in decreased visual acuity, lack of color discrimination, abnormal intolerance to light (ph...
Source: Molecular Diagnosis and Therapy - Category: Molecular Biology Source Type: research
Yakugaku Zasshi. 2021;141(12):1307-1317. doi: 10.1248/yakushi.21-00158-1.ABSTRACTThe number of patients with exudative age-related macular degeneration, diabetic retinopathy and retinal vein occlusion is expected to rise in proportion with the aging of the population and increasing diabetes patients. Also, they are the most common diseases caused by intraocular neovascularization and are often difficult to treat. Currently, anti-vascular endothelial growth factor (VEGF) therapy has been developed and has demonstrated excellent results in treating macular edema, and many patients have avoided blindness. Unfortunately, there...
Source: Yakugaku Zasshi : Journal of the Pharmaceutical Society of Japan - Category: Drugs & Pharmacology Authors: Source Type: research
BACKGROUND A long-held goal of vision therapy is to transfer information directly to the visual cortex of blind individuals, thereby restoring a rudimentary form of sight. However, no clinically available cortical visual prosthesis yet exists.METHODS We implanted an intracortical microelectrode array consisting of 96 electrodes in the visual cortex of a 57-year-old person with complete blindness for a 6-month period. We measured thresholds and the characteristics of the visual percepts elicited by intracortical microstimulation.RESULTS Implantation and subsequent explantation of intracortical microelectrodes were carried o...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
J Virol. 2021 Dec 1:JVI0198521. doi: 10.1128/JVI.01985-21. Online ahead of print.ABSTRACTHSV-1 latency associated transcript (LAT) plays a significant role in efficient establishment of latency and reactivation. LAT has antiapoptotic activity and downregulates expression of components of the Type I interferon pathway. LAT also specifically activates expression of the herpesvirus entry mediator (HVEM), one of seven known receptors used by HSV-1 for cell entry that is crucial for latency and reactivation. However, the mechanism by which LAT regulates HVEM expression is not known. LAT encodes two sncRNAs that are not miRNAs, ...
Source: Herpes - Category: Infectious Diseases Authors: Source Type: research
Clinicians usually easily recognize cranial manifestations of giant cell arteritis (GCA) such as new-onset headache, jaw claudication, scalp tenderness, and abrupt changes in visual acuity or blindness; however, when presented with an aberrant clinical course, the diagnosis becomes more elusive. In addition to temporal arteries and other extracranial branches of the carotid arteries, large vessel vasculitis (LVV) can also affect other blood vessels including coronary arteries, aorta with its major branches, intracranial blood vessels, and hepatic arteries.
Source: JCR: Journal of Clinical Rheumatology - Category: Rheumatology Tags: Concise Reports Source Type: research
Color vision deficiency (formerly known as color blindness) is common as a congenital and as an acquired condition. Some professions, most famously commercial aviation, require their members to demonstrate normal color vision. In the United States and United Kingdom, no restriction is placed on the ability of the color-deficient doctor to practice medicine, although there is evidence that certain clinical discriminations are harder for such doctors. Generally ignored has been the difficulty and the potential for error that arises from the use of color codes in clinical equipment. In this review, we introduce the basic conc...
Source: Journal of Patient Safety - Category: Health Management Tags: Review Articles Source Type: research
Nature, Published online: 01 December 2021; doi:10.1038/d41586-021-03576-2Age-related macular degeneration is the leading cause of blindness in older adults, but techniques are being developed to offset the worst of the damage.
Source: Nature AOP - Category: Research Source Type: research
Retinopathy of prematurity (ROP) blindness is largely preventable, with many countries having already established programs for its timely identification. However, ∼93% of infants screened do not develop ROP severe enough to require treatment.1 As reported in this issue ofPediatrics by Coyner et al.2 artificial intelligence (AI) is innovative methodology to optimize the timing of ROP examinations. For example, it can predict whether an eye will not require treatment, reducing the number of examinations needed while also predicting which eyes need closer surveillance. This is an important development because it would mak...
Source: PEDIATRICS - Category: Pediatrics Source Type: research
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