Differential anti-ischemic efficacy and therapeutic time window of trans- and cis-hinokiresinols: Stereo-specific antioxidant and anti-inflammatory activities.

Differential anti-ischemic efficacy and therapeutic time window of trans- and cis-hinokiresinols: Stereo-specific antioxidant and anti-inflammatory activities. Neuropharmacology. 2013 Jan 1; Authors: Ju C, Hwang S, Cho GS, Kondaji G, Song S, Prather PL, Choi Y, Kim WK Abstract During cerebral ischemia, neurons are injured by various mechanisms including excitotoxicity, oxidative stress, and inflammatory responses. Thus, pharmacological manipulation of multiple cytotoxic pathways has been pursued for the treatment of ischemic injury. Cis-hinokiresinol, a naturally occurring phenylpropanoid, was previously reported to possess anti-oxidant, anti-inflammatory and estrogen-like activities. In the present study, we investigated anti-ischemic effects of trans- and cis-hinokiresinols using in vitro as well as in vivo experimental models. The ORAC and DPPH assays showed that two isomers had similar free radical scavenging activities. However, only trans-hinokiresinol significantly decreased neuronal injury in cultured cortical neurons exposed to oxygen-glucose deprivation (75 min) followed by re-oxygenation (9 h). The differential neuroprotective effect could be due to the stereo-specific augmentation of Cu/Zn-SOD activity by trans-hinokiresinol, when compared with cis-hinokiresinol. Similarly, in rats subjected to transient middle cerebral artery occlusion (1.5 h) followed by 24-h reperfusion, pre-ischemic treatment with trans-hinokiresinol, ...
Source: Neuropharmacology - Category: Drugs & Pharmacology Authors: Tags: Neuropharmacology Source Type: research

Related Links:

Central fever following ischemic stroke is fairly common and associated with worse outcomes. Might the NSAID diclofenac sodium be an effective antipyretic in this situation?Journal of Medical Case Reports
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Journal Article Source Type: news
This study focused on the safety and efficacy of recanalizing therapies in heart failure patients with acute ischemic stroke. How does HF impact the long-term prognosis of these patients?Stroke
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery Journal Article Source Type: news
Condition:   Stroke, Acute Intervention:   Diagnostic Test: 3D CEST imaging Sponsors:   King's College Hospital NHS Trust;   King's College London Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
We present the case of a 68 year-old man who was initially attended in emergency department with sudden onset diplopia. Neurological exploration revealed WEBINO and gait ataxia. Relevant medical history included liver transplantation and subsequent tacrolimus prescription. Complementary exams revealed ischemic lesion in mesencephalic tegmentum, involving medial longitudinal fasciculus and pretectal area. WEBINO syndrome is unfrequent. Among its etiologies, ischemic and demyelinating are the most frequent. In our case, iatrogenic etiology was also considered. Clinical recognition of this syndrome is required to perform adeq...
Source: Archivos de la Sociedad Espanola de Oftalmologia - Category: Opthalmology Tags: Arch Soc Esp Oftalmol Source Type: research
Publication date: Available online 24 February 2020Source: Pharmacology &TherapeuticsAuthor(s): Concetta Schiano, Giuditta Benincasa, Monica Franzese, Nunzia Della Mura, Katia Pane, Marco Salvatore, Claudio NapoliAbstractThe complex pathobiology underlying cardiovascular diseases (CVDs) has yet to be explained. Aberrant epigenetic changes may result from alterations in enzymatic activities, which are responsible for putting in and/or out the covalent groups, altering the epigenome and then modulating gene expression. The identification of novel individual epigenetic-sensitive trajectories at single cell level might pro...
Source: Pharmacology and Therapeutics - Category: Drugs & Pharmacology Source Type: research
(Regenstrief Institute) Patients with a transient ischemic attack (TIA), also known as mini-stroke, are at high risk of more vascular events, including repeated TIAs, stroke and death yet are less likely to be admitted to the hospital for treatment than patients with stroke. Hospital admission and being seen by a neurologist are associated with better quality care according to a new study.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
Alteplase is the only Food and Drug Administration-approved intravenous (IV) thrombolytic medication for acute ischemic stroke. However, multiple recent studies comparing tenecteplase and alteplase suggest that tenecteplase is at least as efficacious as alteplase with regards to neurologic improvement. When given at 0.25 milligrams per kilogram (mg/kg), tenecteplase may have less bleeding complications than alteplase as well. This narrative review evaluates the literature and addresses the practical issues with regards to the use of tenecteplase versus alteplase for acute ischemic stroke, and it recommends that physicians ...
Source: Western Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
In this study we report the initial results of the first code stroke and fibrinolysis pathway established in a level 2 public hospital in a small city (pop 300,000) in Ecuador.Objective: To develop an organized and coordinated pathway within the hospital for the correct diagnosis and treatment of patients with clinical presentation of stroke, starting with early identification of signs/symptoms and the activation of a specific pathway, which in turn improves the prognosis and the quality of life of acute ischemic stroke patients.Methods: This was a prospective, longitudinal,...
Source: Western Journal of Emergency Medicine - Category: Emergency Medicine Source Type: research
This secondary analysis of the POINT randomized clinical trial examines the association between race and risk of early ischemic stroke recurrence after a minor ischemic stroke or transient ischemic attack among US participants.
Source: JAMA Neurology - Category: Neurology Source Type: research
AbstractBackgroundBiomarkers indicative of intracerebral hemorrhage (ICH) may help triage acute stroke patients in the pre-hospital phase. We hypothesized that serum concentration of glial fibrillary acidic protein (GFAP) in combination with ubiquitin carboxy-terminal hydrolase-L1 (UCH-L1), measured by a rapid bio-assay, could be used to distinguish ICH from ischemic stroke.MethodsThis prospective two-center study recruited patients with a clinical diagnosis of acute stroke both in the pre-hospital phase and at hospital admission (within 4 and 6  h after symptom onset, respectively). Blood samples were analyzed for co...
Source: Neurocritical Care - Category: Neurology Source Type: research
More News: Antidoxidants | Brain | Drugs & Pharmacology | Ischemic Stroke | Neurology | Stroke | Study