Anti‐platelet Activity of Erythro‐(7S,8R)‐7‐acetoxy‐3,4,3`,5`‐tetramethoxy‐8‐O‐4`‐neolignan from Myristica fragrans

In this study, we investigated the anti‐platelet activity of erythro‐(7S,8R)‐7‐acetoxy‐3,4,3`,5`‐tetramethoxy‐8‐O‐4`‐neolignan (EATN), a neolignan isolated from Myristica fragrans, using human platelets. EATN preferentially inhibited thrombin‐ and platelet‐activating factor (PAF)‐induced platelet aggregation without affecting platelet damage in a concentration‐dependent manner with IC50 values of 3.2 ± 0.4 and 3.4 ± 0.3 μM, respectively. However, much higher concentrations of EATN were required to inhibit platelet aggregation induced by arachidonic acid. EATN also inhibited thrombin‐induced serotonin and ATP release, and thromboxane B2 formation in human platelets. Moreover, EATN caused an increase in cyclic AMP (cAMP) levels and attenuated intracellular Ca2+ mobilization in thrombin‐activated human platelets. Therefore, we conclude that the inhibitory mechanism of EATN on platelet aggregation may increase cAMP levels and subsequently inhibit intracellular Ca2+ mobilization by interfering with a common signaling pathway rather than by directly inhibiting the binding of thrombin or PAF to their receptors. This is the first report of the anti‐platelet activity of EATN isolated from M. fragrans. Copyright © 2013 John Wiley &Sons, Ltd.
Source: Phytotherapy Research - Category: Biochemistry Authors: Tags: Research Article Source Type: research

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His brand is crisis, so it can be hard to keep abreast of the various calamities President Trump stumbles into or deliberately courts. Now that tensions with Iran seem to have momentarily cooled, another recent episode of Trumpian brinksmanship, closer to home, deserves some attention before we lurch forward into new dangers.  As you ’ve surely heard, but may have already forgotten amid the fog of near-war, three weeks ago, President Trump threatened to declare yet another national emergency at the southern border. If Mexico didn’t sufficiently crack down on cross-border migration,Trump warned, he ’d...
Source: Cato-at-liberty - Category: American Health Authors: Source Type: blogs
DR M ASHRAF MANSOUR (Grand Rapids, MI): Dr Mayor and colleagues queried the National Inpatient Sample (NIS) for carotid interventions between 2005 and 2015. They stopped collecting data after October 2015 because we switched to ICD-10 and they were afraid of contaminating their data. They found more than 1,242,000 patients in this database. These patients received either carotid endarterectomy or stent. Roughly 41.5% were women. Interestingly, only 11.3% were symptomatic. Their studies showed the highest rate of stroke in their patients was in symptomatic women having a carotid stent, followed by symptomatic women having an endarterectomy.
Source: Journal of the American College of Surgeons - Category: Surgery Tags: Western surgical association article Source Type: research
Condition:   Spasticity as Sequela of Stroke Intervention:   Sponsor:   Ipsen Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conclusions: We found no association between weekend admission and 30-day readmissions, providing indirect evidence of homogeneity in the quality of care delivered during week day and weekend admissions.Cerebrovasc Dis Extra 2019;9:66 –71
Source: Cerebrovascular Diseases Extra - Category: Neurology Source Type: research
Cerebrovasc Dis 2019;47:103 –104
Source: Cerebrovascular Diseases - Category: Neurology Source Type: research
CONCLUSIONS: It appears that cycling has a positive effect on walking speed, walking ability and balance. Functional electrical stimulation combined with cycling has positive effects on balance beyond cycling alone. PMID: 31227660 [PubMed - in process]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
CONCLUSIONS: Neurological patients showed a misperception of the verticality, estimated using the SVV. The neurological pathology that most alters the SVV is stroke. PMID: 31227659 [PubMed - in process]
Source: NeuroRehabilitation - Category: Rehabilitation Tags: NeuroRehabilitation Source Type: research
CONCLUSIONS: Multiple sessions of STT practice can improve paretic arm function and decrease TCI bilaterally, with no additional benefit of prior cTBS. Our results suggest that improvement in STT practice following M1c cTBS scaled with change in paretic arm function in some individuals. Our results highlight the need for a better understanding of the mechanisms of cTBS to effectively identify who may benefit from this form of brain stimulation. PMID: 31227676 [PubMed - in process]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
This study aimed to assess the time course of hemodynamic patterns of cortical sensorimotor areas using functional near infrared spectroscopy (fNIRS) and motor recovery within three months after a stroke. METHOD: Eight right-handed first ischemic/hemorrhagic stroke patients (60±8 years, 3 women) with mild to severe hemiparesis were examined with repetitive fNIRS measurements and motor recovery tests (Fugl-Meyer score) during two months. Hemodynamic changes over the ipsilesional and contralesional sensorimotor areas were collected from a multi-channel fNIRS system during intermittent isometric muscle contractions...
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
CONCLUSIONS: In this pilot study, repeated sessions of bi-hemispheric tDCS coupled with resistance training were found safe and tolerable for individuals at the chronic phase post-stroke. However, the use of tDCS did not result in additional sensorimotor improvements when compared to sham-tDCS. Further research is needed to better assess the clinical benefits of combining non-invasive transcranial stimulation with rehabilitation after a stroke. PMID: 31227673 [PubMed - as supplied by publisher]
Source: Restorative Neurology and Neuroscience - Category: Neurology Tags: Restor Neurol Neurosci Source Type: research
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