New stem cell approach for blindness successful in mice

Blind mice can see again, after Oxford University researchers transplanted developing cells into their eyes and found they could re-form the entire light-sensitive layer of the retina.
Source: ScienceDaily Headlines - Category: Science Source Type: news

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CONCLUSION: Our results show a promising approach to provide bullous keratopathy patients with an iPS-cell-based cell therapy to recover useful vision.PMID:34411973 | DOI:10.1016/j.scr.2021.102497
Source: Cell Research - Category: Cytology Authors: Source Type: research
Chronic graft-versus-host disease (cGVHD) is the most common late complication following allogeneic stem cell transplantation (SCT). This disease has variable features resembling autoimmune disorders such as scleroderma, primary biliary cirrhosis, bronchiolitis obliterans, and chronic immunodeficiency1. Thus, cGVHD can lead to debilitating complications such as joint contractures, blindness, and end-stage lung disease, which has a major impact on both survival and quality of life (QOL).
Source: Biology of Blood and Marrow Transplantation - Category: Hematology Authors: Source Type: research
Curr Stem Cell Res Ther. 2021 Jun 22. doi: 10.2174/1574888X16666210622124555. Online ahead of print.ABSTRACTAs the ocular disorders causing long-term blindness or optical abnormalities of the ocular tissue affect the quality of life of patients to a large extent, awareness of their corresponding pathogenesis and the earlier detection and treatment need more consideration. Though current therapeutics result in desirable outcomes, they do not offer an inclusive solution for development of visual impairment to blindness. Accordingly, stem cells, because of their particular competencies, have gained extensive attention for app...
Source: Current Stem Cell Research and Therapy - Category: Stem Cells Authors: Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
The destruction of limbal stem cells (LSCs) and/or the stem cell niche leads to their dysfunction or deficiency.1,2 Limbal stem cell deficiency (LSCD) is characterized by conjunctivalization, persistent or recurrent epithelial defects, ocular surface inflammation, neovascularization, and scarring.2,3 LSCD is one of the causes of corneal blindness,1 particularly in severe cases, such as total LSCD. Researchers have proposed various surgical treatments in combination with corneal transplantation, including the direct transplantation of limbal tissues,4,5 transplantation of ex vivo/in vivo expanded LSCs,6 –9 transplanta...
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Source Type: research
J Cell Mol Med. 2021 May 5. doi: 10.1111/jcmm.16501. Online ahead of print.ABSTRACTLimbal stem cells (LSC) maintain the transparency of the corneal epithelium. Chemical burns lead the loss of LSC inducing an up-regulation of pro-inflammatory and pro-angiogenic factors, triggering corneal neovascularization and blindness. Adipose tissue-derived mesenchymal stem cells (AT-MSC) have shown promise in animal models to treat LSC deficiency (LSCD), but there are not studies showing their efficacy when primed with different media before transplantation. We cultured AT-MSC with standard medium and media used to culture LSC for clin...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Fight Aging! publishes news and commentary relevant to the goal of ending all age-related disease, to be achieved by bringing the mechanisms of aging under the control of modern medicine. This weekly newsletter is sent to thousands of interested subscribers. To subscribe or unsubscribe from the newsletter, please visit: https://www.fightaging.org/newsletter/ Longevity Industry Consulting Services Reason, the founder of Fight Aging! and Repair Biotechnologies, offers strategic consulting services to investors, entrepreneurs, and others interested in the longevity industry and its complexities. To find out m...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Age-related macular degeneration (AMD) is a highly prevalent form of blindness caused by loss death of cells of the retinal pigment epithelium (RPE). Transplantation of pluripotent stem cell (PSC)-derived RPE ...
Source: Stem Cell Research and Therapy - Category: Stem Cells Authors: Tags: Research Source Type: research
Adv Exp Med Biol. 2021;1256:265-293. doi: 10.1007/978-3-030-66014-7_11.ABSTRACTAge-related macular degeneration (AMD) is a leading cause of blindness worldwide. The pathogenesis of AMD involves dysfunction and loss of the retinal pigment epithelium (RPE), a monolayer of cells that provide nourishment and functional support for the overlying photoreceptors. RPE cells in mammals are not known to divide, renew or regenerate in vivo, and in advanced AMD, RPE loss leads to degeneration of the photoreceptors and impairment of vision. One possible therapeutic approach would be to support and replace the failing RPE cells of affec...
Source: Advances in Experimental Medicine and Biology - Category: Research Authors: Source Type: research
This article expresses sentiments regarding medical technology and human longevity that we'd all like to see more of in the mainstream media. At some point, it will come to be seen by the average person as basically sensible to work towards minimizing the tide of suffering and death caused aging and age-related disease. It has been, in hindsight, a strange thing to live in a world in which most people were reflexively opposed to that goal. Death and aging constitute a mystery. Some of us die more quickly. We often ask about it as children, deny it in youth, and reluctantly come to accept it as adults. Aging is uni...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
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