Introduction of the New Editor-in-Chief of Pediatric Neurology

Dr. E. Steve Roach has accepted the offer to be the new Editor-in-Chief of Pediatric Neurology. Dr. Roach is currently the Chief, Division of Pediatric Neurology at The Ohio State University College of Medicine; he is also the current President of the Child Neurology Society. Dr. Roach brings a broad background of interest, experience, and expertise to his new position. He has been an astute and conscientious member of the editorial board of Pediatric Neurology for many years. Childhood stroke and tuberous sclerosis are among his primary interests. He has published extensively, and his skills will hold him in good stead as he assumes his new role.
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Editorials Source Type: research

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In conclusion, T2D impairs vascular function by dysregulated autophagy. Therefore, autophagy could be a potential target for overcoming diabetic microvascular complications. To What Degree Does Loss of Skeletal Muscle with Age Contribute to Immunosenescence? Sarcopenia, the progressive loss of muscle mass and strength, is characteristic of aging. A perhaps surprisingly large fraction of the losses can be averted by strength training, but there are nonetheless inexorable process...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, our study suggests that DEX exerts a neuroprotection against OGD-induced astrocytes injury via activation of astrocytes autophagy by regulating the TSC2/mTOR signaling pathway, which provides a new insight into the mechanisms of DEX treatment for acute ischemic injury.
Source: NeuroMolecular Medicine - Category: Neurology Source Type: research
Abstract BACKGROUND: Gray matter (GM) imaging is important in the investigation of many neurological diseases, including schizophrenia, multiple sclerosis, stroke, Alzheimer's disease, tuberous sclerosis, and epilepsy, which are all associated with changes in cortical GM. OBJECTIVE: The aim of this study was to develop a quantitative statistical analysis system for double inversion recovery (DIR) MRI and to evaluate the new system using preliminary clinical data. METHODS: The study population comprised of 10 healthy volunteers and six patients with or without brain degeneration. A quantitative statistica...
Source: Technology and Health Care - Category: Medical Devices Authors: Tags: Technol Health Care Source Type: research
ConclusionAZD2014 was detrimental to neurons that underwent ischemia. AZD2014 appeared to reduce hamartin, a known neuroprotective mediator, thereby preventing any beneficial effects of mTOR inhibition. Further characterization of the role of individual mTOR complexes (mTORC1 and mTORC2) and their upstream and downstream regulators are necessary to reveal whether these pathways are neuroprotective targets for stroke.
Source: Neuroscience Letters - Category: Neuroscience Source Type: research
ABSTRACT The authors present an historical review of aspects of the life of Professor Manuel R. G ómez, a Spanish neuropediatrician, who graduated in Havana and is known internationally for his work while he was in charge of Pediatric Neurology at the Mayo Clinic in Rochester, USA. His main contribution was related to the tuberous sclerosis complex, demystifying the Vogt triad previously used a s a diagnostic criterion, and he was considered the “ father of the tuberous sclerosis complex “ in the USA.RESUMO Os autores apresentam uma revis ão histórica sobre aspectos da vida do professor Man...
Source: Arquivos de Neuro-Psiquiatria - Category: Neurology Source Type: research
Condition:   Tuberous Sclerosis Complex Interventions:   Drug: Vigabatrin;   Drug: Placebo Sponsors:   Martina Bebin;   National Institute of Neurological Disorders and Stroke (NINDS) Not yet recruiting - verified July 2016
Source: - Category: Research Source Type: clinical trials
Summary BackgroundTuberous sclerosis complex (TSC) is caused by mutations in TSC1 and TSC2, leading to mammalian target of rapamycin hyperactivation. Patients with TSC develop hamartomas in brain, lungs, liver and skin. Two epidemiological studies, performed in Minnesota, U.S.A., have estimated the incidence of TSC to be 0·28–0·56 per 100 000 person‐years (PY), based on
Source: British Journal of Dermatology - Category: Dermatology Authors: Tags: Epidemiology Source Type: research
On March 10-12, 2015, the National Institute of Neurological Disorders and Stroke and the Tuberous Sclerosis Alliance sponsored a workshop in Bethesda, Maryland to assess progress and new opportunities for research in tuberous sclerosis complex with the goal of updating the 2003 Research Plan for Tuberous Sclerosis ( In addition to the National Institute of Neurological Disorders and Stroke and Tuberous Sclerosis Alliance, participants in the strategic planning effort and workshop included representatives from six other Institutes of the National Institut...
Source: Pediatric Neurology - Category: Neurology Authors: Tags: Topical Review Source Type: research
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