CLC-3 channels in cancer (Review).

CLC-3 channels in cancer (Review). Oncol Rep. 2014 Nov 21; Authors: Hong S, Bi M, Wang L, Kang Z, Ling L, Zhao C Abstract Ion channels are involved in regulating cell proliferation and apoptosis (programed cell death). Since increased cellular proliferation and inhibition of apoptosis are characteristic features of tumorigenesis, targeting ion channels is a promising strategy for treating cancer. CLC-3 is a member of the voltage-gated chloride channel superfamily and is expressed in many cancer cells. In the plasma membrane, CLC-3 functions as a chloride channel and is associated with cell proliferation and apoptosis. CLC-3 is also located in intracellular compartments, contributing to their acidity, which increases sequestration of drugs and leads to chemotherapy drug resistance. In this review, we summarize the recent findings concerning the involvement of CLC-3 in cancer and explore its potential in cancer therapy. PMID: 25421907 [PubMed - as supplied by publisher]
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research

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Molecules, Vol. 27, Pages 731: Advances in Management of Bladder Cancer—The Role of Photodynamic Therapy Molecules doi: 10.3390/molecules27030731 Authors: Tomasz Kubrak Michał Karakuła Marcin Czop Aleksandra Kawczyk-Krupka David Aebisher Photodynamic therapy (PDT) is a non-invasive and modern form of therapy. It is used in the treatment of non-oncological diseases and more and more often in the treatment of various types of neoplasms in various locations including bladder cancer. The PDT method consists of local or systemic application of a photosensitizer, i.e., a photosensitive compound that accum...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
This article critically evaluates the concurrent use of dietary omega-3 PUFA as an adjuvant to cancer therapies, reviews the findings in studies using nanoparticle formulations, and delineates the importance of spatiotemporal manipulation of oxidative stress by pharmaceutical nanotechnology for improving outcomes with cancer therapies using various examples. We hope this review will shed light on rational design of nano-formulations to turn harmful pathological oxidative stress into useful pharmacological modalities by manipulating the location and timing of free-radical generation.PMID:35064476 | DOI:10.1007/s13346-021-01104-3
Source: Cell Research - Category: Cytology Authors: Source Type: research
Biochim Biophys Acta Rev Cancer. 2022 Jan 17:188681. doi: 10.1016/j.bbcan.2022.188681. Online ahead of print.ABSTRACTCytotoxic chemotherapy and targeted therapies help people with advanced cancers, but for most, treatment fails. Cancer heterogeneity is one cause of treatment failure, but also suggests an opportunity to improve outcomes; reconceptualising cancer therapy as an ecological problem offers the strategy of adaptive therapy. If an agent is active against a patient's cancer, instead of traditional continuous dosing at the maximum tolerated dose until treatment failure, the patient and their oncologist may instead c...
Source: Biochimica et Biophysica Acta - Category: Biochemistry Authors: Source Type: research
ConclusionChemotherapy exposure affected DOR occurrence in 60.9% of patients with childhood and adolescence cancer. Moreover, it also altered menstrual regularity in 34.8% and delayed puberty development in 8.7% subjects.
Source: Archives of Gynecology and Obstetrics - Category: OBGYN Source Type: research
In conclusion, the present study identified novel antitumor mechanisms of 2‑Cl‑IB‑MECA in pancreatic and hepatocellular carcinoma in vitro that further underscores the importance of A3AR agonists in cancer therapy.PMID:35039871 | DOI:10.3892/ijmm.2022.5086
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Clin Transl Oncol. 2022 Jan 17. doi: 10.1007/s12094-021-02770-y. Online ahead of print.ABSTRACTCancer is one of the leading causes of death, with a heavy socio-economical burden for countries. Despite the great advances that have been made in the treatment of cancer, chemotherapy is still the most common method of treatment. However, many side effects, including hepatotoxicity, renal toxicity, and cardiotoxicity, limit the efficacy of conventional chemotherapy. Over recent years, natural products have attracted attention as therapeutic agents against various diseases, such as cancer. Resveratrol (RES), a natural polyphenol...
Source: Cell Research - Category: Cytology Authors: Source Type: research
Expert Opin Investig Drugs. 2022 Jan 15. doi: 10.1080/13543784.2022.2030311. Online ahead of print.ABSTRACTINTRODUCTION: HER2 positive gastric cancer is a distinct subgroup overexpressing the HER2 receptor. For a decade, first-line Trastuzumab was the only licensed HER2-directed therapy for HER2 positive advanced gastric cancer following results from the ToGA trial in 2010 demonstrating a survival benefit when added to chemotherapy. Within the last year, significant advances have taken place in the field of HER2-directed gastric cancer therapy.AREAS COVERED: This review discusses pivotal clinical trial results and summaris...
Source: Expert Opinion on Investigational Drugs - Category: Drugs & Pharmacology Authors: Source Type: research
AbstractCancer is one of the leading causes of death, with a heavy socio-economical burden for countries. Despite the great advances that have been made in the treatment of cancer, chemotherapy is still the most common method of treatment. However, many side effects, including hepatotoxicity, renal toxicity, and cardiotoxicity, limit the efficacy of conventional chemotherapy. Over recent years, natural products have attracted attention as therapeutic agents against various diseases, such as cancer. Resveratrol (RES), a natural polyphenol occurring in grapes, nuts, wine, and berries, exhibited potential for preventing and t...
Source: Clinical and Translational Oncology - Category: Cancer & Oncology Source Type: research
Int J Biol Macromol. 2022 Jan 13:S0141-8130(22)00029-0. doi: 10.1016/j.ijbiomac.2022.01.022. Online ahead of print.ABSTRACTCombination chemotherapy has attracted more attention in the field of anticancer treatment due to the synergetic effects achieved in the targeted delivery of anticancer drugs. In the present work a hydrogel-based drug delivery system (CS-NSA/A-HA) was successfully developed from chitosan modified by nitrosalicylaldehyde and aldehyde hyaluronic acid. Anticancer drugs, Cisplatin (CDDP) and Doxorubicin (DOX) were incorporated into this hydrogel separately and a dual drug loaded system was synthesized and ...
Source: International Journal of Biological Macromolecules - Category: Biochemistry Authors: Source Type: research
This study illustrates how hapten-based pre-immunization (for anti-hapten antibodies production) combi ned with cancer receptor labeling with hapten antigen constructs can elicit antibody-dependent cellular phagocytosis (ADCP). Thus, the hapten antigen 2,4-dinitrophenol (DNP) was covalently combined with a cancer receptor-binding dipeptide (IYIY) to form a dipeptide-hapten construct (IYIY-DNP, MW =  1322.33) that targets the tropomyosin receptor kinase C (TrkC)-expressed on the surface of metastatic cancer cells. IYIY-DNP facilitated selective association of RAW264.7 macrophages to the TrkC expressing 4T1 can...
Source: Cancer Immunology, Immunotherapy - Category: Cancer & Oncology Source Type: research
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