Fasting and OGTT-Derived Measures of Insulin Resistance as Compared with the Euglycemic-Hyperinsulinemic Clamp in Non-diabetic Finnish Offspring of Type 2 Diabetic Individuals.

Fasting and OGTT-Derived Measures of Insulin Resistance as Compared with the Euglycemic-Hyperinsulinemic Clamp in Non-diabetic Finnish Offspring of Type 2 Diabetic Individuals. J Clin Endocrinol Metab. 2014 Nov 11;:jc20142299 Authors: Lorenzo C, Haffner SM, Stančáková A, Kuusisto J, Laakso M Abstract Context: It remains to be established which surrogate marker is the most predictive of insulin resistance. Objective: We evaluated the incremental value of Matsuda insulin sensitivity index (Matsuda ISI) to homeostasis model assessment of insulin resistance (HOMA-IR) for detecting insulin resistance. Design and Setting: Cross-sectional analysis of the EUGENE2 Kuopio cohort. Participants: A total of 266 non-diabetic Finnish offspring of type 2 diabetic individuals (aged 24 - 50 years). Main measures: Insulin resistance (the lowest whole-body glucose uptake quartile) was measured by the euglycemic-hyperinsulinemic clamp. We used the area under the receiver operating characteristic curve (AUC), an insensitive method to model improvement. Reclassification was assessed by the net reclassification improvement (NRI) and integrated discrimination improvement (IDI). We generated four strata using, as cut points, the 0.05, 0.25, and 0.70 probabilities of having insulin resistance. These were observed probabilities at body mass index of 20, 27, and 35 kg/m(2), respectively. Results: The AUC of Matsuda ISI based on 5 time points (0, 30, 60, 90 and 120 min...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research

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Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Source Type: research
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Source: Current Issues in Molecular Biology - Category: Molecular Biology Authors: Source Type: research
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Source: JAMA - Category: General Medicine Source Type: research
In this study, C57BL/6 mice under a high fat diet (HFD) were treated with sodium copper chlorophyllin (CHL), a water-soluble derivative of chlorophyll, in drinking water. After 28 weeks of HFD feeding, liver steatosis was established accompanied by gut microbiota dysbiosis, intestinal impairment, endotoxemia, systemic inflammation, and insulin resistance. Administration of CHL effectively alleviated systemic and intestinal inflammation and maintained tight junction in the intestinal barrier. CHL rebalanced gut microbiota in the mice under high fat feeding and attenuated hepatic steatosis, insulin resistance, dyslipidemia, ...
Source: Frontiers in Physiology - Category: Physiology Source Type: research
Nature Reviews Endocrinology, Published online: 26 October 2021; doi:10.1038/s41574-021-00575-1This Review summarizes adaptive immune cell dysregulation in obesity and type 2 diabetes mellitus (T2DM). Under-appreciated comorbidities of obesity and T2DM (oral cavity inflammation, neuroinflammation and dysbiosis) are considered, and previous clinical trials of anti-inflammatory therapies for T2DM are discussed.
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Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
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