Fasting and OGTT-Derived Measures of Insulin Resistance as Compared with the Euglycemic-Hyperinsulinemic Clamp in Non-diabetic Finnish Offspring of Type 2 Diabetic Individuals.

Fasting and OGTT-Derived Measures of Insulin Resistance as Compared with the Euglycemic-Hyperinsulinemic Clamp in Non-diabetic Finnish Offspring of Type 2 Diabetic Individuals. J Clin Endocrinol Metab. 2014 Nov 11;:jc20142299 Authors: Lorenzo C, Haffner SM, Stančáková A, Kuusisto J, Laakso M Abstract Context: It remains to be established which surrogate marker is the most predictive of insulin resistance. Objective: We evaluated the incremental value of Matsuda insulin sensitivity index (Matsuda ISI) to homeostasis model assessment of insulin resistance (HOMA-IR) for detecting insulin resistance. Design and Setting: Cross-sectional analysis of the EUGENE2 Kuopio cohort. Participants: A total of 266 non-diabetic Finnish offspring of type 2 diabetic individuals (aged 24 - 50 years). Main measures: Insulin resistance (the lowest whole-body glucose uptake quartile) was measured by the euglycemic-hyperinsulinemic clamp. We used the area under the receiver operating characteristic curve (AUC), an insensitive method to model improvement. Reclassification was assessed by the net reclassification improvement (NRI) and integrated discrimination improvement (IDI). We generated four strata using, as cut points, the 0.05, 0.25, and 0.70 probabilities of having insulin resistance. These were observed probabilities at body mass index of 20, 27, and 35 kg/m(2), respectively. Results: The AUC of Matsuda ISI based on 5 time points (0, 30, 60, 90 and 120 min...
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research

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ConclusionsOur results suggest that the peroxisome proliferator ‐activated receptor gamma 2Ala12 variant has significant protective effects against albuminuria and DN.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: Original Article Source Type: research
AbstractBackground/ObjectiveNon ‐alcoholic fatty liver disease (NAFLD) is more and more common in patients with type 2diabetes mellitus (T2DM). Currently, some researches have found that Sodium glucose co‐ transporter2 (SGLT2) inhibitors, a new hypoglycemic drug, can improve nonalcoholic fatty liver besides hypoglycemic effect . Thus, we undertook a meta‐analysis of randomized controlled trials (RCTs) to evaluate the efficacy of SGLT2 inhibitors on the treatment of NAFLDMethodsPubMed, Embase and the Cochrane Library were searched for RCTs of SGLT2 inhibitors in patients with NAFLD and T2DM up to Oct1, 2019. Differenc...
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
ConclusionMetabolic biomarkers were affected by blood sample timing and underlying metabolic disease. The JECS will clarify the influences of metabolic status during pregnancy on the health and development of the offspring in future studies.
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: ORIGINAL ARTICLE Source Type: research
In conclusion, the present study illustrated that the effects of OFS and MET combined treatment on gut microbiota, especially for the MET-induced side effect-related ones, and host metabolism were of greater magnitude than individual OFS or MET treatment in obese rats and mice. Therefore, it is likely that combined administration of OFS and MET may offer a novel and promising strategy for reducing side effects induced by MET and improving metabolic outcomes, particularly glycemia control and weight reduction.
Source: Frontiers in Endocrinology - Category: Endocrinology Source Type: research
The objective of the current phenomenological study was to describe how diabetes-related distress might be uniquely experienced by older adults (age ≥65) with type 2 diabetes mellitus (T2DM). Interpretive phenomenology guided the research design and analysis. Everyday life experiences of living with T2DM and elevated diabetes distress were investigated with interpretive interviews. The most prevalent lived experiences were strained relationships with health care providers, guilt, fear, loneliness, and forgetfulness. These experiences created challenges in managing diabetes and increased diabetes-related distress. Improv...
Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
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Source: Medscape Cardiology Headlines - Category: Cardiology Tags: Diabetes & Endocrinology News Alert Source Type: news
Conditions:   Retinal Function;   Cognitive Dysfunction;   Microperimetry Intervention:   Sponsors:   Hospital Universitari Vall d'Hebron Research Institute;   Queen's University, Belfast;   Association for Innovation and Biomedical Research on Light and Image;   UMC Utrecht;   University of Medical Centre Amsterdam;   University of Rome Tor Vergata;   Ospedale San Raffaele;   University of Milan;   University of Southern Denmark;   Azienda Ospedaliero Uni...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Quality of Life;   Diabetes Mellitus, Type 2;   Adherence, Medication;   Diet Habit Intervention:   Sponsors:   Universiteit Antwerpen;   Artesis Plantijn University College, Antwerp;   Université Mohammed Premier, Oujda;   Vliruos Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Retinal Function;   Cognitive Dysfunction;   Microperimetry Intervention:   Sponsors:   Hospital Universitari Vall d'Hebron Research Institute;   Queen's University, Belfast;   Association for Innovation and Biomedical Research on Light and Image;   UMC Utrecht;   University of Medical Centre Amsterdam;   University of Rome Tor Vergata;   Ospedale San Raffaele;   University of Milan;   University of Southern Denmark;   Azienda Ospedaliero Uni...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Quality of Life;   Diabetes Mellitus, Type 2;   Adherence, Medication;   Diet Habit Intervention:   Sponsors:   Universiteit Antwerpen;   Artesis Plantijn University College, Antwerp;   Université Mohammed Premier, Oujda;   Vliruos Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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