Transplantation of Fas-deficient or wild-type neural stem/progenitor cells (NPCs) is equally efficient in treating experimental autoimmune encephalomyelitis (EAE).

Transplantation of Fas-deficient or wild-type neural stem/progenitor cells (NPCs) is equally efficient in treating experimental autoimmune encephalomyelitis (EAE). Am J Transl Res. 2014;6(2):119-28 Authors: Hackett C, Knight J, Mao-Draayer Y Abstract Studies have shown that neural stem/progenitor cell (NPC) transplantation is beneficial in experimental autoimmune encephalomyelitis (EAE), an established animal model of multiple sclerosis (MS). It is unclear whether NPCs have the ability to integrate into the host CNS to replace lost cells or if their main mechanism of action is via bystander immunomodulation. Understanding the mechanisms by which NPCs exert their beneficial effects as well as exploring methods to increase post-transplantation survival and differentiation is critical to advancing this treatment strategy. Using the EAE model and Fas-deficient (lpr) NPCs, we investigated the effects of altering the Fas system in NPC transplantation therapy. We show that transplantation of NPCs into EAE mice ameliorates clinical symptoms with greater efficacy than sham treatments regardless of cell type (wt or lpr). NPC transplantation via retro-orbital injections significantly decreased inflammatory infiltrates at the acute time point, with a similar trend at the chronic time point. Both wt and lpr NPCs injected into mice with EAE were able to home to sites of CNS inflammation in the periventricular brain and lumbar spinal cord. Both wt and lpr NPCs have the ...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research

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CONCLUSION: Partial bladder recovery has been evident after SC therapy in SCI models. Due to limitations in the number of studies in other neurological diseases, additional studies are necessary to confirm the detailed mechanism for bladder recovery. PMID: 33017895 [PubMed]
Source: International Neurourology Journal - Category: Urology & Nephrology Tags: Int Neurourol J Source Type: research
If you ask health care providers about the most challenging condition to treat, chronic pain is mentioned frequently. By its nature, chronic pain is a complex and multidimensional experience. Pain perception is affected by our unique biology, our mood, our social environment, and past experiences. If you or a loved one is suffering from chronic pain, you already know the heavy burden. People are looking for novel, nonaddictive ways to treat pain Given the ongoing challenges of chronic pain management coupled with the consequences of the opioid epidemic, pain management practitioners and their patients are searching for eff...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Back Pain Marijuana Pain Management Source Type: blogs
Authors: Das J, Sharrack B, Snowden JA Abstract INTRODUCTION: Autologous hematopoietic stem cell transplantation (AHSCT) has become increasingly popular in recent years as an effective treatment of immune mediated neurological diseases. Treatment related mortality has significantly reduced primarily through better patient selection, optimization of transplant technique and increased center experience. Area covered: Multiple sclerosis is the main indication, but people with neuromyelitis optica spectrum disorder, stiff person spectrum disorder, chronic inflammatory demyelinating polyneuropathy, myasthenia gravis and ot...
Source: Expert Review of Neurotherapeutics - Category: Neurology Tags: Expert Rev Neurother Source Type: research
Conclusions: These data suggest that combined intravenous and intrathecal low-dose hUC-MSCs transplantation is safe and feasible in RRMS and NMO patients in the long term. The conclusion requires confirmation by future clinical trials in a larger cohort.
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Emerging evidence suggests intestinal microbiota as a central contributing factor to the pathogenesis of Relapsing-Remitting-Multiple-Sclerosis (RRMS). This novel RRMS study evaluated the impact of fecal-microbiota-transplantation (FMT) on a broad array of physiological/clinical outcomes using deep metagenome sequencing of fecal microbiome. FMT interventions were associated with increased abundances of putative beneficial stool bacteria and short-chain-fatty-acid metabolites, which were associated with increased/improved serum brain-derived-neurotrophic-factor levels and gait/walking metrics. This proof-of-concept single-s...
Source: Frontiers in Neurology - Category: Neurology Source Type: research
In conclusion, using a large cohort with rich health and DNA methylation data, we provide the first comparison of six major epigenetic measures of biological ageing with respect to their associations with leading causes of mortality and disease burden. DNAm GrimAge outperformed the other measures in its associations with disease data and associated clinical traits. This may suggest that predicting mortality, rather than age or homeostatic characteristics, may be more informative for common disease prediction. Thus, proteomic-based methods (as utilised by DNAm GrimAge) using large, physiologically diverse protein sets for p...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Mélange intéressante: COVID-19, autologous transplants and multiple sclerosis. Hematology. 2020 Dec;25(1):320 Authors: Olivares Gazca JC, Gómez Almaguer D, Gale RP, Ruiz Argüelles GJ PMID: 32783598 [PubMed - in process]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
Publication date: October 2020Source: Multiple Sclerosis and Related Disorders, Volume 45Author(s): Richard K Burt, Paul Tappenden, Xiaoqiang Han, Kathleen Quigley, Indira Arnautovic, Basil Sharrack, John A Snowden, Daniel Hartung
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
AbstractIsolated neuroinflammatory disease has been described in case reports of familial hemophagocytic lymphohistiocytosis (FHL), but the clinical spectrum of disease manifestations, response to therapy and prognosis remain poorly defined. We combined an international survey with a literature search to identify FHL patients with (i) initial presentation with isolated neurological symptoms; (ii) absence of cytopenia and splenomegaly at presentation; and (iii) systemic HLH features no earlier than 3  months after neurological presentation. Thirty-eight (20 unreported) patients were identified with initial diagnoses in...
Source: Journal of Clinical Immunology - Category: Allergy & Immunology Source Type: research
AbstractBlood-brain barrier disruption is one of the hallmarks of multiple sclerosis. Mesenchymal stem cells showed great potential for the multiple sclerosis therapy. However, the effect of mesenchymal stem cells on blood-brain barrier in multiple sclerosis remains unclear. Here, we investigated whether mesenchymal stem cells transplantation protected blood-brain barrier integrity and further explored possible underlying mechanisms. Adult female C57BL/6 mice were immunized with myelin oligodendrocyte glycoprotein peptide33-55 (MOG33-55) to induce experimental autoimmune encephalomyelitis (EAE). Mesenchymal stem cells (5 &...
Source: Molecular Neurobiology - Category: Neurology Source Type: research
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