Profiling bacterial community in upper respiratory tracts
Background: Infection by pathogenic viruses results in rapid epithelial damage and significantly impacts on the condition of the upper respiratory tract, thus the effects of viral infection may induce changes in microbiota. Thus, we aimed to define the healthy microbiota and the viral pathogen-affected microbiota in the upper respiratory tract. In addition, any association between the type of viral agent and the resultant microbiota profile was assessed. Methods: We analyzed the upper respiratory tract bacterial content of 57 healthy asymptomatic people (17 health-care workers and 40 community people) and 59 patients acutely infected with influenza, parainfluenza, rhino, respiratory syncytial, corona, adeno, or metapneumo viruses using culture-independent pyrosequencing. Results: The healthy subjects harbored primarily Streptococcus, whereas the patients showed an enrichment of Haemophilus or Moraxella. Quantifying the similarities between bacterial populations by using Fast UniFrac analysis indicated that bacterial profiles were apparently divisible into 6 oropharyngeal types in the tested subjects. The oropharyngeal types were not associated with the type of viruses, but were rather linked to the age of the subjects. Moraxella nonliquefaciens exhibited unprecedentedly high abundance in young subjects aged
Publication date: Available online 8 October 2020Source: Microbes and InfectionAuthor(s): Keisuke Nishioka, Michihito Kyo, Takaaki Nakaya, Nobuaki Shime
ConclusionsPatients on various solid tumour treatments achieve sero-protection rate congruent with the general population. The sero-protection HIA titres were not sustained at 24 weeks postvaccination.
Comparison of deaths from the coronavirus (COVID-19) with deaths from influenza (flu) and pneumonia. Includes deaths by date of death occurrence and breakdowns by sex and age.
CONCLUSIONS: Promoting asthma self-management education, influenza vaccinations, nebulizers, and spacers can decrease the frequency of healthcare utilization and asthma-related expenditures while improving medication adherence. PMID: 33031709 [PubMed - as supplied by publisher]
CONCLUSIONS: Our results underscore how erroneous reporting of 1 condition can lead to underreporting of other causes of death. Misapplication or misunderstanding of procedures by medical providers, rather than extrinsic factors influencing the reporting process, are key drivers of erroneous cause-of-death reporting. PMID: 33031711 [PubMed - as supplied by publisher]
Publication date: Available online 7 October 2020Source: The Annals of Thoracic SurgeryAuthor(s): Rony Atoui, Fady Ebrahim F, Kevin Saroka, John Mireau, Janet E. McElhaney, Gregory Hare
Since its emergence the impact of COVID-19 has been profound, and the public health challenge seem to be the most serious seen in a respiratory virus since the 1918 H1N1 influenza pandemic (Soper 1919). Following its emergence in Wuhan, cases of COVID-19 were exported outside of China, mainly by travelers using the global aviation networks (Wu et al., 2020). It should be noted that transboundary spread of viruses is quite common in veterinary medicine (Klausner et al., 2015, 2017, 2018).
The COVID-19 pandemic exerts inflammation-related parasympathetic complications and post-infection manifestations with major inter-individual variability. To seek the corresponding transcriptomic origins for the impact of COVID-19 infection and its aftermath consequences, we sought the relevance of long and short non-coding RNAs (ncRNAs) for susceptibility to COVID-19 infection. We selected inflammation-prone men and women of diverse ages among the cohort of Genome Tissue expression (GTEx) by mining RNA-seq datasets from their lung, and blood tissues, followed by quantitative qRT-PCR, bioinformatics-based network analyses ...
Publication date: Available online 7 October 2020Source: American Journal of Infection ControlAuthor(s): Peng-jun Lu, Anup Srivastav, Tammy A. Santibanez, Ashley Amaya, Jill A. Dever, Jessica Roycroft, Marshica Stanley Kurtz, Walter W. Williams