Donna Altenpohl on Ebola

Ebola response is a model of collaboration The constant stream of photos and reports about Ebola from West Africa tragically illustrate the speed at which disease can spread, devastating communities and reshaping daily life. GSK is working with many partners at an unprecedented speed and with passionate focus to try to develop a vaccine to limit the total number of deaths from this epidemic and future outbreaks. While the current crisis is our focus, there also are lessons for the future: US health and security can be threatened by events half a world away and the global community is not fully prepared for such disease outbreaks. We commend world health authorities, governments, public and private entities for their commitment and collaboration to aggressively meet this urgent health need, but we acknowledge the need to improve our preparations to respond to other global health crises before the next outbreak or epidemic. Americans have lived through such threats, including the anthrax-containing letters mailed to Congressional offices and the 2009 H1N1 influenza pandemic that caused more than 10,000 deaths.  We must move now to prevent and contain future epidemics, whether it is Ebola or another emerging infectious disease. The World Health Organization (WHO) convened a meeting last week with governments, agencies, charities and companies, including GSK, to agree how to accelerate testing and deployment of vaccines that could restrict the evolution of this epidemic. GSK...
Source: PHRMA - Category: Pharmaceuticals Authors: Source Type: news

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ConclusionsDespite previous reports in Argentina, ST258 is no longer the absolute clone among KPC-Kp isolates. In the present study, dissemination of more virulent lineages such as the hypermucoviscous ST25 was detected. The emergence of the high-risk clone ST307 and occurrence of blaKPC-3 was noticed for the first time in this region.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionsThis study suggests that chronic respiratory diseases and shortness of breath are independent risk factors for influenza B virus–associated pneumonia in adult patients.
Source: American Journal of Infection Control - Category: Infectious Diseases Source Type: research
Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate K2[B3O3F4OH] inhibits emerging multidrug-resistant and β-lactamase-producing opportunistic pathogens. Drug Dev Ind Pharm. 2019 Aug 16;:1-21 Authors: Maravić A, Rončević T, Krce L, Ilić N, Galić B, Čikeš Čulić V, Carev I Abstract Halogenated boroxine dipotassium trioxohydroxytetrafluorotriborate, K2[B3O3F4OH] (boroxine) was previously shown to be very effective in inhibition of several carcinoma cell lines, including the skin cancer. Here, we investigated its antimicrobial potential by targeting the multidrug-resistan...
Source: Drug Development and Industrial Pharmacy - Category: Drugs & Pharmacology Tags: Drug Dev Ind Pharm Source Type: research
Conclusion: Uveitis episodes happened more frequently under rainy and windy conditions. Most factors were not significantly correlated to attacks. PMID: 31418617 [PubMed - as supplied by publisher]
Source: Ocular Immunology and Inflammation - Category: Allergy & Immunology Tags: Ocul Immunol Inflamm Source Type: research
Authors: Hon KL, Leung AKC, Leung K, Chan GCF PMID: 31416996 [PubMed - in process]
Source: Hong Kong Medical Journal - Category: General Medicine Tags: Hong Kong Med J Source Type: research
ConclusionA Bayesian approach for transmission route reconstruction using epidemiologic data and genomic variants from WGS can be applied in actual VRE outbreaks. This may contribute to the design and implementation of effective infection control measures.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
ConclusionTo successfully control the outbreak a customized bundled approach was necessary. Current guidelines should be adapted to be suitable for all types of residential care homes and to effectively combat the spread of multi resistant pathogens.
Source: Journal of Hospital Infection - Category: Infectious Diseases Source Type: research
Publication date: Available online 16 August 2019Source: Journal of Ayurveda and Integrative MedicineAuthor(s): Sushma Bagde Bhatwalkar, Prashant Shukla, Rupesh K. Srivastava, Rajesh Mondal, Rajaneesh AnupamAbstractEnvironmental disinfection greatly reduces the occurrence of nosocomial or healthcare associated infections (HCAIs) which are the major healthcare problems worldwide. In India, Ayurvedic traditional fumigation with natural plant products is used to disinfect environment. In the present study, environmental disinfection efficiency of traditional fumigation practice has been evaluated by using natural plant produc...
Source: Journal of Ayurveda and Integrative Medicine - Category: Complementary Medicine Source Type: research
Publication date: December 2019Source: Materials Science and Engineering: C, Volume 105Author(s): Rebeca T. Steipel, Matthew D. Gallovic, Cole J. Batty, Eric M. Bachelder, Kristy M. AinslieAbstractAlso known as electrospray, electrohydrodynamic atomization has been used extensively in the last 15 years to develop polymer-based particles for drug delivery in cell and animal models. More recently, novel core-shell, multi-axial, and other electrospray particles have been developed from an array of polymers for a variety of biomedical applications. This review focuses on electrospray as a novel method of particle fabrication...
Source: Materials Science and Engineering: C - Category: Materials Science Source Type: research
In this study, 13-15-months-old Holstein-Friesian steers were immunised with a subunit vaccine as a prime and a modified vaccinia Ankara vector as a boost, both expressing a chimeric multi-antigen (rMABbo – rMVA). This antigen includes the immunodominant B and T cell epitopes of three B. bovis proteins: merozoite surface antigen - 2c (MSA - 2c), rhoptry associated protein 1 (RAP - 1) and heat shock protein 20 (HSP20). Responses were compared with the Babesia bovis live attenuated vaccine used in Argentina (R1A). Eleven weeks after the first immunisation, all bovines were challenged by the inoculation of a virulent B....
Source: Ticks and Tick borne Diseases - Category: Zoology Source Type: research
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