Ectopic ACTH and CRH co-secreting tumors in children and adolescents causing Cushing syndrome: a diagnostic enigma and how to solve it.

Conclusions: Ectopic ACTH/CRH co-secreting tumors are extremely rare in children and adolescents. Its diagnosis is frequently missed and is sometimes confused with CD due to the effect of CRH on the pituitary. PMID: 25291050 [PubMed - as supplied by publisher]
Source: The Journal of Clinical Endocrinology and Metabolism - Category: Endocrinology Authors: Tags: J Clin Endocrinol Metab Source Type: research

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ConclusionsAdrenal LPA are a heterogeneous group of tumors, mostly composed of oncocytomas. Up to 1/3 of those tumors may have a borderline-malignant potential at histopathology.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
ConclusionACC is a rare neoplasm characterized by a high risk of recurrence after surgical resection.
Source: International Journal of Surgery Case Reports - Category: Surgery Source Type: research
We present a case of a 22-year-old woman with ectopic ACTH-dependent Cushing syndrome due to an appendicular carcinoid, which was localized with the help of 68Ga-DOTATATE PET/CT scan.
Source: Clinical Nuclear Medicine - Category: Nuclear Medicine Tags: Interesting Images Source Type: research
We present a case of severe PCOS (Hyperthecosis ovarii) which mimics androgen secreting tumour from ovary in a 30- yr- old lady. This case emphasizes on the spectrum of manifestations that PCOS can come with and the importance of trans vaginal ultrasonography in diagnosing ovarian conditions and its superiority over conventional trans abdominal USG or CT scan. PMID: 31562730 [PubMed - in process]
Source: Journal of the Association of Physicians of India - Category: General Medicine Tags: J Assoc Physicians India Source Type: research
Authors: Soedarso MA, Nugroho KH, Prabowo E, Listiana DE, Soesilowati D, Santoso AG Abstract A 20-year old  man was admitted for evaluation of Cushing's syndrome. He presented with a history of headache, fatique, mood disorder, hypertension (Blood Pressure 170/120 mmHg), moon face, buffalo hump, striae rubrae.  Cortisol serum laboratory increased  33.53 µgr/dl (Normal range: 3.09 - 16.6µgr/dl). Abdominal CT Scan showed a right adrenal mass diameter 10.53 x 6.83 cm, with calcified and necrotized area.Levels of ACTH
Source: Acta medica Indonesiana - Category: Internal Medicine Tags: Acta Med Indones Source Type: research
Purpose of review Adrenal tumors occur in 5% of population with higher prevalence in elderly. Patients with adrenal tumors present with overt hormonal excess in up to 15% of cases, and mild autonomous cortisol secretion in 30–40% of cases. Overt Cushing syndrome, mild autonomous cortisol secretion, pheochromocytoma, and primary aldosteronism have been associated with higher cardiovascular morbidity and mortality. Increasing experimental and clinical evidence also suggests that adrenal hormone excess is detrimental to bone health. This review aims to discuss the effect of cortisol, aldosterone, and catecholamine exc...
Source: Current Opinion in Endocrinology, Diabetes and Obesity - Category: Endocrinology Tags: ADRENAL CORTEX AND MEDULLA: Edited by Irina Bancos Source Type: research
Conclusions: The diagnosis of adrenocortical oncocytoma mainly depends on the pathological examination. Surgical resection is the main treatment method. Introduction The oncocytic adrenocortical neoplasm is a rare tumor of the adrenal gland. Since it was first reported in 1986 (1), there has been serial case reports to try to illuminate this rare tumor. However, there is still rather little information available, especially the pathological and follow-up data, to illustrate the biological behavior of this particular tumor. The origin, biological behavior, diagnostic criteria, and prognosis of oncocytic adrenocortic...
Source: Frontiers in Oncology - Category: Cancer & Oncology Source Type: research
In this study, we found that senescent chondrocytes isolated from OA patients secrete more EVs compared with nonsenescent chondrocytes. These EVs inhibit cartilage ECM deposition by healthy chondrocytes and can induce a senescent state in nearby cells. We profiled the miR and protein content of EVs isolated from the synovial fluid of OA joints from mice with SnCs. After treatment with a molecule to remove SnCs, termed a senolytic, the composition of EV-associated miR and protein was markedly altered. The senolytic reduced OA development and enhanced chondrogenesis, and these were attributable to several specific differenti...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Wang K, Liu F, Wu C, Liu Y, Qi L, Yang X, Zheng H, Ma A, Wu J, Yan F, Hou X, Chen L, Dong M, Hou W Abstract Cushing's syndrome (CS) is a clinical syndrome characterized by hypercortisolemia. Cyclic Cushing's syndrome (CCS), which exhibits a periodic or irregular increasing pattern in cortisol, is a rare type of Cushing's syndrome. A 37-year-old man came to our hospital because of repeated dizzy spells, weakness and hypercortisolemia lasting two weeks. Endocrinological examinations indicated CCS with periodic and intermittent increases in cortisol. Enhanced computed tomography (CT) revealed space occupying ...
Source: Endocrine Journal - Category: Endocrinology Tags: Endocr J Source Type: research
Rationale: Ectopic adrenal tissue is the adrenal rests along the path from gonads to adrenal glands during embryogenesis. Ectopic adrenocortical adenoma is a rare disease represented with over-production of cortisol by the ectopic adrenocortical tissue. Patient concerns: An 18-year-old Chinese female patient was presented with weight-gain for 6 months. She had elevated plasma cortisol and a solitary mass was revealed using computed tomography scan in the left renal hilum. Diagnosis: The tumor was removed and the immunohistochemical profile indicated an ectopic adrenocortical adenoma. Interventions: After the tum...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
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