Scientists wield plant viruses against deadly human disease

(Case Western Reserve University) Case Western Reserve University researchers have won grants to customize a plant virus into a vaccine for an aggressive form of breast cancer, and to turn another plant virus into a transporter that delivers clot-busting drugs to a blood clot before it causes a heart attack or stroke.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Platelets are crucial for normal hemostasis; however, their hyperactivation also contributes to many potentially lethal pathologies including myocardial infarction, stroke, and cancer. We hypothesized that modified platelets lacking their aggregation and activation capacity could act as reversible inhibitors of platelet activation cascades. Here, we describe the development of detergent-extracted human modified platelets (platelet decoys) that retained platelet binding functions but were incapable of functional activation and aggregation. Platelet decoys inhibited aggregation and adhesion of platelets on thrombogenic surfa...
Source: Science Translational Medicine - Category: Biomedical Science Authors: Tags: Research Articles Source Type: research
As artificial intelligence tools have been invading more or less every area of healthcare, we made a list to keep track of the top smart algorithms aiming for better diagnostics, more sophisticated patient care or further sighted predictions of diseases. Does A.I. beat doctors? Only if you lived under a rock for the last couple of years, could you not have heard about artificial intelligence. Some might have even come across the spread and potential of A.I. in healthcare. Not only smart algorithms themselves but also the hype around A.I. has grown immensely, thus every time a new study about deep learning or machine...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence in Medicine AI cancer death future Health Healthcare pathology prediction Radiology technology Source Type: blogs
AbstractTo investigate the occurrence of thrombotic events (myocardial infarction, deep vein thrombosis or ischemic stroke) in a group of 39 cases of severe FXII deficiency during a mean 22.5  years follow-up. All patients seen in Padua during the years 1968–2006 will the object of this investigation. FXII was less than or 1% of normal in all cases. Factor FXII activity in unaffected family members was 98% (range 90–140%). No patient or control had a thrombotic event in the past and none were on anticoagulant therapy. FV Leiden was present in one patient and in two controls whereas the G to A20210 prothrom...
Source: Journal of Thrombosis and Thrombolysis - Category: Hematology Source Type: research
In conclusion, this is the first report to show that pyroptotic cell death occurs in the aging brain and that the inflammasome can be a viable target to decrease the oxidative stress that occurs as a result of aging. Reducing Levels of Protein Manufacture Slows Measures of Aging in Nematodes https://www.fightaging.org/archives/2018/12/reducing-levels-of-protein-manufacture-slows-measures-of-aging-in-nematodes/ Researchers here demonstrate that an antibiotic slows aging in nematode worms, providing evidence for it to work through a reduction in protein synthesis. Beyond a slowing of aging, one of the con...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
This study's researchers approached all people turning 85 in 2006 in two cities in the UK for participation. At the beginning of the study in 2006-2007, there were 722 participants, 60 percent of whom were women. The participants provided researchers with information about what they ate every day, their body weight and height measurements, their overall health assessment (including any level of disability), and their medical records. The researchers learned that more than one-quarter (28 percent) of very old adults had protein intakes below the recommended dietary allowance. The researchers noted that older adults w...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
In conclusion, weight cycling significantly increased life-span relative to remaining with obesity and had a similar benefit to sustained modest weight loss. Support for Oxidized Cholesterol as a Primary Cause of Atherosclerosis https://www.fightaging.org/archives/2018/11/support-for-oxidized-cholesterol-as-a-primary-cause-of-atherosclerosis/ In the paper I'll point out today, the authors provide evidence in support of the concept that it is specifically oxidized cholesterol that is the primary cause of atherosclerosis rather than the condition resulting from too much cholesterol in general. In atheroscl...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Abstract Acute pulmonary embolism (PE) is the third most common acute cardiovascular disease, after myocardial infarction and stroke. The optimal diagnostic strategy for suspected PE among experts remains controversial, and it can differ based on factors related to the health care setting (i.e., urban, rural, or remote) that may impact access to diagnostic technologies. For instance, provision of timely diagnosis may be more challenging in rural and remote facilities due to lack of access to certain testing and imaging modalities and specialist expertise, as well as geographical barriers to care. Inabili...
Source: Rural Remote Health - Category: Rural Health Tags: Book Source Type: research
Our panel this morning discussed the issues surrounding how the WHI results were interpreted and communicated to women and their health care providers. We recognize that hormones are not appropriate for all women, and look forward to hosting a future panel that highlights alternatives. The speakers have a variety of backgrounds and experiences (and genders), and we aim to promote diversity of voices. This was not normal breakfast conversation. Today was a jolting – and disruptive – talk about what happens to women’s bodies when they age. (Who knew that if you’re menopausal and you don’t take y...
Source: Disruptive Women in Health Care - Category: Consumer Health News Authors: Tags: Uncategorized Source Type: blogs
AbstractOsteoporosis, a disease of low bone mass, places individuals at enhanced risk for fracture, disability, and death. In the USA, hospitalizations for osteoporotic fractures exceed those for heart attack, stroke, and breast cancer and, by 2025, the number of fractures due to osteoporosis is expected to rise to nearly three million in the USA alone. Pharmacological treatments for osteoporosis are aimed at stabilizing or increasing bone mass. However, there are significant drawbacks to current pharmacological options, particularly for long-term management of this chronic condition. Moreover, the drug development pipelin...
Source: Clinical Reviews in Bone and Mineral Metabolism - Category: Internal Medicine Source Type: research
Do menopause treatments such as estrogen and HRT cause heart attack, stroke and breast cancer? ... Here's a look at the history, safety and efficacy of these methods.
Source: AARP.org News - Category: American Health Source Type: news
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