Planarian Resistance to Blades and Bugs.

Planarian Resistance to Blades and Bugs. Cell Host Microbe. 2014 Sep 10;16(3):271-272 Authors: Petersen CP Abstract Planarians famously can regenerate after decapitation. In this issue, Abnave et al. (2014) find they resist infection by multiple bacterial species pathogenic to humans, Drosophila and C. elegans, including M. tuberculosis. These results identify a conserved gene controlling phagocytosis and establish planarians as a powerful system for analyzing host-pathogen interactions. PMID: 25211069 [PubMed - as supplied by publisher]
Source: Cell Host and Microbe - Category: Microbiology Authors: Tags: Cell Host Microbe Source Type: research

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Trends in Elevated Blood Lead Levels Using 5 and 10 µg/dL Levels of Concern Among Refugee Children Resettled in Massachusetts, 1998-2015. Public Health Rep. 2019 Sep 20;:33354919874078 Authors: Geltman PL, Smock L, Cochran J Abstract OBJECTIVES: Refugee children are known to have a high prevalence of elevated blood lead levels (EBLLs). We sought to determine trends in EBLLs among refugee children during an 18-year period and examine relationships between descriptive characteristics and EBLLs by using 10 µg/dL and 5 µg/dL levels of concern. METHODS: We retrospectively evaluated ref...
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
CONCLUSIONS: Our findings indicate that persons experiencing homelessness bear an undue burden of tuberculosis mortality in Texas. The burden may be related to poorer health caused by poverty stressors, comorbidities, or lack of access to health care. PMID: 31539480 [PubMed - as supplied by publisher]
Source: Public Health Reports - Category: International Medicine & Public Health Tags: Public Health Rep Source Type: research
We report 1 known false-negative, in a patient who developed disseminated TB on anti-TNF therapy. Indeterminate testing rates were higher at IBD diagnosis than during treatment (10.3% vs 5.3%, P 
Source: Journal of Pediatric Gastroenterology and Nutrition - Category: Gastroenterology Tags: Original Articles: Gastroenterology: Inflammatory Bowel Disease Source Type: research
Conclusions: Anthropometric, genetic, and dosage characteristics of Mexican patients with TB are an important source of risk for subtherapeutic plasma concentrations of anti-TB drugs. Factors such as lower-than-recommended RMP dose, male patients with TB, and MDR1 3435 genotype, in addition to age group, body mass index, and INH acetylator phenotype based on NAT2 genotype, should be considered during treatment.
Source: Therapeutic Drug Monitoring - Category: Drugs & Pharmacology Tags: Original Article Source Type: research
Conclusion: Our study first implied that the A variant of rs17687727 in TGFBRAP1 influenced the susceptibility to ATDILI in first-line antituberculosis combination treatment in the Han Chinese population in a dependent manner. PMID: 31534460 [PubMed]
Source: Evidence-based Complementary and Alternative Medicine - Category: Complementary Medicine Tags: Evid Based Complement Alternat Med Source Type: research
Multidrug-resistant tuberculosis (MDR-TB) is a major public health concern in the UK and globally. Treatment is prolonged, more toxic and less effective compared to that for drug susceptible TB. In 2018 and then consolidated in 2019, the World Health Organisation (WHO) published major revisions to guidelines, prioritising the new drug bedaquiline and down-grading the injectable agents (aminoglycosides and polypeptides) which had played a major part in previous guidelines.1,2 Changes were based on meta-analysis data of efficacy, accumulating trial data supporting bedaquiline and ethical concerns regarding the side effect pr...
Source: Journal of Infection - Category: Infectious Diseases Authors: Source Type: research
Molecules, Vol. 24, Pages 3433: Investigation of 5’-Norcarbocyclic Nucleoside Analogues as Antiprotozoal and Antibacterial Agents Molecules doi: 10.3390/molecules24193433 Authors: Anastasia L. Khandazhinskaya Elena S. Matyugina Pavel N. Solyev Maggie Wilkinson Karen W. Buckheit Robert W. Buckheit Larisa N. Chernousova Tatiana G. Smirnova Sofya N. Andreevskaya Khalid J. Alzahrani Manal J. Natto Sergey N. Kochetkov Harry P. de Koning Katherine L. Seley-Radtke Carbocyclic nucleosides have long played a role in antiviral, antiparasitic, and antibacterial therapies. Recent results from ou...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
We report the case of a 10-year-old child treated for latent tuberculosis infection (LTBI) with pyrazinamide (PZA) and levofloxacin after contact with a smear-positive multidrug-resistant tuberculosis adult. Over the course of the treatment, the patient developed a drug-induced fulminant hepatitis attributed to the combination of PZA and levofloxacin. This case highlights the hepatotoxicity of the association of second-line anti-TB treatment in children.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
Background: The incidence of drug-resistant forms of tuberculosis (DR-TB) and the number of children treated with second-line drugs (SLDs) are increasing. However, limited amount of information is available regarding the use of SLDs in this population. Methods: To describe the treatment of pediatric TB with SLDs and factors associated with use of SLDs in children with and without documented DR-TB, records of pediatric TB patients referred to a center in Italy from 2007 to 2018 were reviewed retrospectively. Results: Of 204 children diagnosed with active TB during the study period, 42 were treated with SLDs because ...
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Antimicrobial Reports Source Type: research
This retrospective study investigated outcomes among lost to follow-up (LTFU) adolescents and young adults (AYAs: 10–24 years of age) with tuberculosis (TB) registered from 2008 to 2014 in Gaborone, using surveillance data. Of 68 LTFU AYAs, 16 repeated treatment; 8 completed and 6 were again LTFU. Of 4 confirmed deaths, 3 had TB/HIV coinfection. Approaches to improve AYA retention in TB care are needed.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Brief Reports Source Type: research
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