Regulation of cannabinoid receptor gene expression and endocannabinoid levels in lymphocyte subsets by IFN-β: a longitudinal study in multiple sclerosis patients.

Regulation of cannabinoid receptor gene expression and endocannabinoid levels in lymphocyte subsets by IFN-β: a longitudinal study in multiple sclerosis patients. Clin Exp Immunol. 2014 Aug 28; Authors: Sánchez López AJ, Román-Vega L, Ramil Tojeiro E, Giuffrida A, García-Merino A Abstract Evidence suggests the involvement of the cannabinoid system in the pathogenesis of MS. We studied CB1 and CB2 receptor gene expression in B, NK and T cells from MS patients before and after one year of interferon beta therapy, and compared these levels to those of healthy controls. We also measured the production of the endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) and the gene expression of the endocannabinoid-degrading enzyme fatty acid amide hydrolase (FAAH) in these cells. Prior to interferon therapy, MS patients showed significantly elevated CB2 expression in B cells, but not in T or NK cells. These levels decreased gradually within 6 months to one year of interferon treatment. CB1 expression was elevated in all cell subsets, but only reached statistical significance in T cells; all levels decreased progressively over time. Before treatment, AEA but not 2-AG levels were significantly elevated in the three cell populations; after one year of treatment, all values decreased to control levels. The expression of FAAH was unchanged. The different expression of cannabinoid receptor genes and the increased level of AE...
Source: Clinical and Developmental Immunology - Category: Allergy & Immunology Authors: Tags: Clin Exp Immunol Source Type: research

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, Casadó V Abstract Dopaminergic and purinergic signaling play a pivotal role in neurological diseases associated with motor symptoms, including Parkinson's disease (PD), multiple sclerosis, amyotrophic lateral sclerosis, Huntington disease, Restless Legs Syndrome (RLS), spinal cord injury (SCI), and ataxias. Extracellular dopamine and adenosine exert their functions interacting with specific dopamine (DR) or adenosine (AR) receptors, respectively, expressed on the surface of target cells. These receptors are members of the family A of G protein-coupled receptors (GPCRs), which is the largest protein superf...
Source: Advances in Pharmacology - Category: Drugs & Pharmacology Authors: Tags: Adv Pharmacol Source Type: research
Publication date: August 2019Source: Biomedical Signal Processing and Control, Volume 53Author(s): Marco Pota, Massimo Esposito, Rosario Megna, Giuseppe De Pietro, Mario Quarantelli, Vincenzo Brescia Morra, Bruno AlfanoAbstractMultiple Sclerosis (MS) is a chronic neuroinflammatory disorder of the brain and spinal cord, widely studied nowadays, due to its relevant prevalence in the population. Even though no cure exists, an earlier and more adequate choice of treatment could delay its evolution and prevent irreversible sequelae and disability progression. Currently, Magnetic Resonance Imaging (MRI) represents an essential n...
Source: Biomedical Signal Processing and Control - Category: Biomedical Science Source Type: research
Publication date: September 2019Source: Multiple Sclerosis and Related Disorders, Volume 34Author(s): Vanesa Pytel, Jordi A. Matias-Guiu, Laura Torre-Fuentes, Paloma Montero-Escribano, Jorge Matias-Guiu
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
We report the case of a first devastating NMOSD attack leading to death despite optimal treatment. While receiving steroids during a bilateral blinding optic neuritis, this female patient suffered a severe attack involving the spinal cord and circumventricular organs (CVOs), including the pineal gland. Early adjunctive daily PE failed to prevent sudden death. AQP4-antibodies were strongly positive.To our knowledge, this is the first case of exceptionally severe monophasic NMOSD leading to full-blown lesions in all AQP4-expressing sites. Lesions of the periventricular ependyma and CVOs are highly exceptional and the involve...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Novartis has won a U.S. federal court order preventing rival generic makers from selling versions of the Swiss drugmaker's top-selling multiple sclerosis medicine Gilenya in the United States, at least until a patent dispute is resolved.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
This study is an important first step toward a better understanding of cognitive dysfunction in individuals with progressive MS,' said Dr. Genova. 'By examining both the cognitive and affective components of Theory of Mind, we found evidence for differential effects of progressive MS, similar to the effects reported for relapsing remitting MS, including the apparent sparing of affective ability. Our findings indicate that VAMA will be an important tool for developing interventions that help individuals maintain the skills needed to function in everyday life.'
Source: EurekAlert! - Social and Behavioral Science - Category: International Medicine & Public Health Source Type: news
In this report we describe a rare case of concurrent AQP4-positive NMOSD and neurosyphilis. A 60-year-old man was admitted to our hospital with a complaint of progressive weakness in his legs for one month. T2-weighted magnetic resonance images of the spinal cord showed longitudinal extensive lesions at C7–T7. The rapid plasma reagin test and T. pallidum particle agglutination assay performed using patient serum and cerebrospinal fluid (CSF) were positive. Additionally, the AQP4-immunoglobulin (Ig) G was detected in the serum and CSF. The patient's symptom gradually improved after penicillin and methylprednisolo...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Publication date: Available online 22 June 2019Source: Multiple Sclerosis and Related DisordersAuthor(s): Tom A. Fuchs, Stefano Ziccardi, Michael G. Dwyer, Leigh E. Charvet, Alexander Bartnik, Rebecca Campbell, Jose Escobar, David Hojnacki, Chana Kolb, Devon Oship, Jeta Pol, Michael T. Shaw, Curtis Wojcik, Faizan Yasin, Bianca Weinstock-Guttman, Robert Zivadinov, Ralph H.B. BenedictAbstractBackgroundGrowing evidence supports the efficacy of restorative cognitive training in people with multiple sclerosis (PwMS), but the effects vary across individuals. Differences in treatment efficacy may be related to baseline individual...
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
Conclusion: PwMS prioritize accessibility, affordability, insurance coverage, and comprehensiveness in MS healthcare services.
Source: Multiple Sclerosis and Related Disorders - Category: Neurology Source Type: research
ConclusionCooccurrence of a seizure in a patient with MS may complicate the management process. In this review, we tried to provide answers to the frequently asked questions, considering the best available scientific evidence and expert opinion.
Source: Epilepsy and Behavior - Category: Neurology Source Type: research
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