High-throughput sequencing of TCR repertoires in multiple sclerosis reveals intrathecal enrichment of EBV-reactive CD8(+) T cells.
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Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Nabil Seery, Vivien Li, Ai-Lan Nguyen, Izanne Roos, Katherine A Buzzard, Roberts Atvars, Nicola Taylor, Kelsey Tunnell, John Carey, Chris Dwyer, Hasini Fernandoa Lisa Taylor, Josephine Baker, Mark P Marriott, Trevor J Kilpatrick, Tomas Kalincik, Mastura Monif
Conclusions: A head-worn IMU during rehabilitation distinguished between groups. Furthermore, within the GPS group, the IMU quantified the progression of the frequency of head movements during gaze stability exercises over time. Video Abstract available for more insights from the authors (see the Video, Supplemental Digital Content 1, available at: http://links.lww.com/JNPT/A320).
Publication date: November 2020Source: Multiple Sclerosis and Related Disorders, Volume 46Author(s): Mia T. Minen, Kathryn B. Schaubhut, Kaitlyn Morio
Publication date: Available online 17 September 2020Source: IDCasesAuthor(s): Pushpinder Kaur, Alana Lewis, Abdul Basit, Nikolas St Cyr, Zaman Muhammad
Researchers have identified five cognitive phenotypes among patients with multiple sclerosis, which can help drive tailored rehabilitative strategies, say researchers.Medscape Medical News
Multiple sclerosis (MS) patients have been considered a higher-risk population for COVID-19 due to the high prevalence of disability and disease-modifying therapy use; however, there is little data identifying clinical characteristics of MS associated with worse COVID-19 outcomes. Therefore, we conducted a multicenter prospective cohort study looking at the outcomes of 40 MS patients with confirmed COVID-19. Severity of COVID-19 infection was based on hospital course, where a mild course was defined as the patient not requiring hospital admission, moderate severity was defined as the patient requiring hospital admission to...
The present study was carried out to investigate any possible linkage between cerebral grey matter volumetric, iron changes, white matter's lesions load and serum iron levels in a group of relapsing-remitting multiple sclerosis (RRMS) patients.
FRIDAY, Sept. 18, 2020 -- Pregnancy can delay the onset of multiple sclerosis (MS) by more than three years, researchers report. The international study found those who'd been pregnant had their first MS symptoms an average of 3.3 years later than...
B cells play a central role in multiple sclerosis (MS) through production of injurious antibodies, secretion of pro-inflammatory cytokines, and antigen presentation. The therapeutic success of monoclonal antib...
ConclusionsWe present 37 high-quality PRM assays across 21 CSF-proteins found to be affected by multiple sclerosis, along with a recommended workflow for future development of new assays. The assays can directly be used by others, thus enabling better comparison between studies. Finally, the assays can robustly and stably monitor biological processes in multiple sclerosis patients over time, thus potentially aiding in diagnosis and prognosis, and ultimately in treatment decisions.