The cardiopulmonary effects of dexmedetomidine infusions in dogs during isoflurane anesthesia

Conclusions and clinical relevanceCardiopulmonary changes associated with LD were within clinically accepted normal ranges whereas HD produced clinically significant changes. The LD may be useful as an anesthetic adjunct in healthy dogs.
Source: Veterinary Anaesthesia and Analgesia - Category: Veterinary Research Authors: Tags: Research Paper Source Type: research

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Cheng Luo1†, Xiqing Bian1†, Qian Zhang2, Zhenyan Xia1, Bowen Liu1, Qi Chen1, Chienchih Ke3,4, Jian-Lin Wu1* and Yonghua Zhao5* 1State Key Laboratory of Quality Research in Chinese Medicine, Faculty of Chinese Medicine, Macau University of Science and Technology, Macau, China 2Department of Biotherapy, Shenzhen Luohu People’s Hospital, Shenzhen, China 3Department of Medical Imaging and Radiological Sciences, Kaohsiung Medical University, Kaohsiung, Taiwan 4Biomedical Imaging Research Center, National Yang-Ming University, Taipei, Taiwan 5State Key Laboratory of Quality Research in Chinese Medi...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: This systematic review and meta-analysis indicates that propofol use for general anesthesia in young healthy children undergoing surgery does not increase complications and that propofol could be at least comparable to other anesthetic agents. PMID: 31001938 [PubMed - in process]
Source: Journal of Korean Medical Science - Category: Biomedical Science Tags: J Korean Med Sci Source Type: research
Authors: Ali A, Dorman Y, Abdullah T, Yasa C, Orhan Sungur M, Akinci IO, Ergin-Ozcan P Abstract BACKGROUND: Pulse pressure variation (PPV) and stroke volume variation (SVV) can predict fluid responsiveness effectively. However, high body mass index (BMI) can restrict their use due to changes in respiratory system compliance (CS), intra-abdominal pressure, and stroke volume (SV) in the prone position. Therefore, we aimed to investigate the effectiveness of mini fluid challenge in predicting fluid responsiveness in obese (BMI ≥30 kg/m2) patients in the prone position. METHODS: A total of 33 patients undergoing...
Source: Minerva Anestesiologica - Category: Anesthesiology Tags: Minerva Anestesiol Source Type: research
Julia B Kendrick, Alan David Kaye, Yiru Tong, Kumar Belani, Richard D Urman, Christopher Hoffman, Henry LiuJournal of Anaesthesiology Clinical Pharmacology 2019 35(5):29-34 Improvement in patient outcomes has become a significant consideration with our limited resources in the surgical setting. The implementation of enhanced recovery pathway protocols has resulted in significant benefits to both the patients and hospitals, such as shorter length of hospital stays, reduction in the rate of complications, and fewer hospital readmissions. An emerging component and a key element for the success of Enhanced Recovery After Surg...
Source: Journal of Anaesthesiology Clinical Pharmacology - Category: Anesthesiology Authors: Source Type: research
(NEW YORK) — Scientists restored some activity within the brains of pigs that had been slaughtered hours before, raising hopes for some medical advances and questions about the definition of death. The brains could not think or sense anything, researchers stressed. By medical standards “this is not a living brain,” said Nenad Sestan of the Yale School of Medicine, one of the researchers reporting the results Wednesday in the journal Nature. But the work revealed a surprising degree of resilience among cells within a brain that has lost its supply of blood and oxygen, he said. “Cell death in the brai...
Source: TIME: Health - Category: Consumer Health News Tags: Uncategorized Brain Activity onetime Source Type: news
In conclusion, our data show some of the brain modifications probably responsible for the behavioral phenotype associated with TBI and suggest the CBD as a pharmacological tool to improve neurological dysfunctions caused by the trauma. Introduction The phytocannabinoid cannabidiol (CBD), the major non-psychoactive constituent of Cannabis sativa, exhibits a broad spectrum of potential therapeutic properties, including neuroprotective effects in Central Nervous System (CNS) disorders (Fernández-Ruiz et al., 2013; De Gregorio et al., 2018; Schonhofen et al., 2018). Through a multitarget mechanism, CBD shows pot...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Apelin-13 Suppresses Neuroinflammation Against Cognitive Deficit in a Streptozotocin-Induced Rat Model of Alzheimer’s Disease Through Activation of BDNF-TrkB Signaling Pathway Huaiqing Luo1, Yang Xiang1, Xiangping Qu1, Huijun Liu1, Chi Liu1, Guangyi Li2, Li Han3*† and Xiaoqun Qin1*† 1Department of Physiology, School of Basic Medical Science, Central South University, Changsha, China 2Department of Anatomy, Histology and Embryology, Changsha Medical University, Changsha, China 3Department of Physiology, School of Basic Medical Science, Changsha Medical University, Changsha, China Alzheimer&rsq...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
In conclusion, the present study identified canagliflozin as a potent inhibitor of human EC proliferation. The anti-proliferative action of canagliflozin is observed in ECs isolated from both the venous and arterial circulation, and is partly due to the blockade of cyclin A expression. In addition, this study found that canagliflozin inhibits tube formation in cultured ECs and mouse aortic rings. Notably, these actions are specific for canagliflozin and not seen with other SGLT2 inhibitors. The ability of canagliflozin to exert these pleiotropic effects on EC function may contribute to both the adverse and salutary actions...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
ConclusionWe thought that CEA remains the most efficient treatment modality among symptomatic and asymptomatic octogenarians with severe carotid artery stenosis and no difference was found compared to non-octogenarians. Advanced age should not be considered as a  high-risk group and selected octogenarians are good candidates for CEA.
Source: European Surgery - Category: Surgery Source Type: research
Hypertensive disorders of pregnancy (HDP) complicate approximately 5-10% of pregnancies. In the past 20 years the incidence of HDPs has increased by 25%.1 These disorders, combined with delayed or inadequate treatment of severe systolic hypertension, continue to be a leading cause of maternal death – nearly one woman dies every day in the United States of America (USA) and there are an additional 50-60,000 deaths per year worldwide.2,3 A vast majority of deaths result from hemorrhagic stroke and the complications of seizures.
Source: International Journal of Obstetric Anesthesia - Category: Anesthesiology Authors: Tags: Review article Source Type: research
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