Nigeria: Malaria Drug Could Prevent Liver Cancer

[Guardian]A CHEAP anti-malarial drug could prevent liver cancer, scientists at University College London have discovered, offering hope for hundreds of thousands who are at risk of the disease
Source: AllAfrica News: Malaria - Category: Infectious Diseases Source Type: news

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Conclusion: There were gaps in detailed knowledge on NCDs, but positive attitude towards routine primary care integrated HIV/NCDs management, showing likely support for implementation of such policy.Keywords: Non-communicable diseases, knowledge, attitude, HIV, integration.
Source: African Health Sciences - Category: African Health Source Type: research
Abstract Tuberculosis is unfortunately once again killing more people than any other infection. Despite global biomedical and public health efforts, standard interventions to control the pandemic have not advanced in most resource-poor settings, in contrast to other global diseases such as malaria and HIV infection. The authors propose that reconsidering concepts of the optimal host immune response to Mycobacterium tuberculosis is required to develop a paradigm that will inform novel interventions. The development of active tuberculosis associated with cancer treatment by immune checkpoint inhibition highlights th...
Source: Am J Respir Crit Car... - Category: Intensive Care Authors: Tags: Am J Respir Crit Care Med Source Type: research
Nanorobots swimming in blood vessels, in silico clinical trials instead of experimenting with drugs on animals and people, remote brain surgeries with the help of 5G networks – the second part of our shortlist on some astonishing ideas and innovations that could give us a glimpse into the future of medicine is ready for you to digest. Here, we’re going beyond the first part with medical tricorders, the CRISPR/Cas-9 gene-editing method, and other futuristic medical technologies to watch for. 11) In silico clinical trials against testing drugs on animals As technologies transform every aspect of healthcare,...
Source: The Medical Futurist - Category: Information Technology Authors: Tags: Artificial Intelligence E-Patients Future of Medicine Future of Pharma Genomics Health Sensors & Trackers 3d printing AI bioprinting blockchain clinical trials CRISPR digital digital health drug development genetics Innovat Source Type: blogs
AbstractAlgeria, like all emerging countries, has been going through a health transition over the past 30  years or so, characterized by a drop in mortality rates, an increase in life expectancy and a change in the causes of death in favor of chronic non-communicable diseases. In the past, the country mainly faced infectious diseases such as typhoid, cholera and malaria. The prevalence of the latter ha s been significantly reduced thanks to the many social health and vaccination programs undertaken by the health authorities. As a result of this epidemiological transition, we are witnessing a growing increase in the in...
Source: Internal and Emergency Medicine - Category: Emergency Medicine Source Type: research
Abstract Macroautophagy (hereafter referred to as autophagy) is a highly conserved, intracellular degradation process characterised by de novo formation of autophagosomes. These double membraned organelles engulf and deliver cargo, for example damaged organelles and protein aggregates, to lysosomes for degradation and recycling. Autophagy is primarily a stress response mechanism activated to survive unfavourable conditions such as starvation or hypoxia. In addition, autophagy functions in differentiation, immune responses against invading microorganisms and tissue remodelling in mammalian cells. Besides its cytopr...
Source: Swiss Medical Weekly - Category: General Medicine Authors: Tags: Swiss Med Wkly Source Type: research
gbe Malaria and cancer are chronic diseases. The challenge with drugs available for the treatment of these diseases is drug toxicity and resistance. Ferrocene is a potent organometallic which have been hybridized with other compounds resulting in compounds with enhanced biological activity such as antimalarial and anticancer. Drugs such as ferroquine were developed from ferrocene and chloroquine. It was tested in the 1990s as an antimalarial and is still an effective antimalarial. Many researchers have reported ferrocene compounds as potent compounds useful as anticancer and antimalarial agents when hybridized with oth...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Publication date: Available online 4 October 2019Source: TrAC Trends in Analytical ChemistryAuthor(s): Pravin Shende, Bala Prabhakar, Amar PatilAbstractColor changing sensors (CCSs) emerge as a novel approach for the diagnosis of various ailments like cancer, diabetes, chronic kidney diseases, neurodegenerative disease and malaria. This review article focusses on the mechanism, historical evolution, types of sensors based on biological fluids, nanomaterials and smart technological aspects of CCSs. The advantages and limitations of CCSs associated with their uses in different fields like diagnosis and food and beverages are...
Source: TrAC Trends in Analytical Chemistry - Category: Chemistry Source Type: research
We present here a novel experimental approach based on mathematical modeling of drug encapsulation efficiency (EE) data in liposomal systems by which microspecies-specific partition coefficients are reported as a function of pH and phospholipid compositions replicating the RBC membrane in a simple and highly translatable manner. This approach has been applied to the study of several diprotic basic antimalarials of major clinical importance (quinine, primaquine, tafenoquine, quinacrine, and chloroquine) describing their respective microspecies distribution in phosphatidylcholine-LP suspensions. Estimated EE data according t...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
Conclusion: The ethanolic leaf extract of X. strumarium is a potent growth inhibitor of Leishmania major and can affect vital metabolic pathways of Leishmania promastigotes. The assay provided new perspectives on the development of novel treatment strategies for leishmanial activity derived from natural products. PMID: 31543914 [PubMed]
Source: Iranian Journal of Parasitology - Category: Parasitology Tags: Iran J Parasitol Source Type: research
AbstractA series of quinoline-chalcone(E)-1-[3 or 4-(7-chloroquinolin-4-ylamino) phenyl]-3-(phenyl substituted) prop-2-ene-1-one (4,5), and quinoline-pyrazoline hybrids 7-Chloro-N-[3 or 4-(4,5-dihydro-5-(phenyl-substituted)-1H-pyrazol-3-yl] phenyl) quinoline-4 –amine (6,7) were synthesized with the aim of achieving an antimalarial and anticancer dual action. Most of the compounds showed significant inhibition (%>80) of β-hematin formation. The existing structures were tested in vivo as potential antimalarials in mice infected withP. berghei ANKA, chloroquine susceptible strain. Some of the compounds exhibited...
Source: Medicinal Chemistry Research - Category: Chemistry Source Type: research
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