A UK Single Centre Retrospective Analysis of the Relationship between Haemodynamic Changes and Outcome in Patients Undergoing Prolonged Left Ventricular Assist Device Support.

Conclusion: Highly significant and favourable haemodynamic changes were found. However, group 3 did not undergo decrease in TPG and PVR possibly because of suboptimal LVAD flow, right heart dysfunction and unavoidable prolongation of support. PMID: 25017117 [PubMed - as supplied by publisher]
Source: Annals of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Authors: Tags: Ann Thorac Cardiovasc Surg Source Type: research

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ConclusionElevated pulmonary artery pressure at a first annual evaluation after HTx was the only hemodynamic variable that predicted impaired outcome in cardiac recipients.
Source: IJC Heart and Vasculature - Category: Cardiology Source Type: research
Publication date: Available online 20 November 2019Source: Canadian Journal of CardiologyAuthor(s): Stefan Elde, Y. Joseph Woo
Source: Canadian Journal of Cardiology - Category: Cardiology Source Type: research
Contributors : Chen L Zheng ; Bi C ChenSeries Type : Expression profiling by arrayOrganism : Rattus norvegicusPost-transplantation diabetes mellitus (PTDM) is a known complication of transplantation which affected the prognosis. Tacrolimus (Tac, or FK506) is a widely used immunosuppressant, has been reported as a risk factor for PTDM and further develops complications in heart and skeletal muscle , while the mechanism is still largely unknown. The gene expression of rat muscles of control group and Tac induced PTDM group were analyzed.
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by array Rattus norvegicus Source Type: research
Condition:   Graft Versus Host Disease (GVHD) Interventions:   Biological: Alpha-1 antitrypsin (AAT);   Drug: Placebo Sponsors:   CSL Behring;   Blood and Marrow Transplant Clinical Trials Network;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
The surgical director of the heart transplant program at Cincinnati Children ’s Hospital has been hired by another leading pediatric hospital.
Source: bizjournals.com Health Care:Biotechnology headlines - Category: Biotechnology Authors: Source Type: news
Condition:   Graft Versus Host Disease (GVHD) Interventions:   Biological: Alpha-1 antitrypsin (AAT);   Drug: Placebo Sponsors:   CSL Behring;   Blood and Marrow Transplant Clinical Trials Network;   National Institutes of Health (NIH);   National Heart, Lung, and Blood Institute (NHLBI);   National Cancer Institute (NCI) Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Sustained, indolent immune injury of the vasculature of a heart transplant limits long-term graft and recipient survival. This injury is mitigated by a poorly characterized, maladaptive repair response. Vascular endothelial cells respond to proangiogenic cues in the embryo by differentiation to specialized phenotypes, associated with expression of apelin. In the adult, the role of developmental proangiogenic cues in repair of the established vasculature is largely unknown. We found that human and minor histocompatibility–mismatched donor mouse heart allografts with alloimmune-mediated vasculopathy upregulated express...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
Since 2005, the United States donor heart allocation system assigned patients awaiting transplantation with measurably distinct outcomes into a single high urgency priority status. In this old system, patients in cardiogenic shock, as well as ambulatory stable patients with complications of a left ventricular assist device (LVAD) were allocated to a similar status of highest urgency (referred to as UNOS Status 1A) and competed equally for donor organs. This led to overcrowding of the list within this high urgency status category with consequent prolongation of waiting times and concerns of inequity in allocation across sev...
Source: The Journal of Heart and Lung Transplantation - Category: Transplant Surgery Authors: Tags: Research Correspondence Source Type: research
AbstractPurpose of ReviewRight heart failure (RHF) following left ventricular assist device implantation (LVAD) remains the primary cause of postoperative mortality and morbidity, and prediction of RHF is the main interest of the transplantation community. In this review, we outline the role and impact of right ventricular strain in the evaluation of the right ventricle function before LVAD implantation.Recent FindingsAccumulating data suggest that measurement of right ventricular longitudinal strain (RVLS) has a critical role in predicting RHF preoperatively and may improve morbidity and mortality following LVAD implantat...
Source: Current Heart Failure Reports - Category: Cardiology Source Type: research
ConclusionsThe high variability of tacrolimus pharmacokinetics early after thoracic organ transplantation is largely due to excessive variability in bioavailability, making individualised dosing based on measured concentrations futile. To bypass this bioavailability issue, we suggest administering tacrolimus intravenously and aiming below the upper therapeutic range early post-transplantation.Clinical Trial Registraion:  NTR 3912/EudraCT 2012-001909-24.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research
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