Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications.
Ultra-performance liquid chromatography-mass spectrometry as a sensitive and powerful technology in lipidomic applications. Chem Biol Interact. 2014 Jul 9; Authors: Zhao YY, Wu SP, Liu S, Zhang Y, Lin RC Abstract Lipidomics, the comprehensive illumination of lipid-based information in biology systems, involves in identifying lipids and profiling lipids and lipid-derived mediators. The development of lipidomics enables the characterization of lipid species and detailed lipid profiling in body fluid, tissue or cell, and allows for a wider understanding of the biological roles of lipid networks. Lipidomic research has been greatly facilitated by recent advances in ultra-performance liquid chromatography-mass spectrometry (UPLC-MS) and involved in lipid extraction, lipid identification and data analysis supporting applications from qualitative and quantitative assessment of multiple lipid species. UPLC technique, different mass spectrometry technique, lipid extraction and data analysis in lipidomics are reviewed. Afterwards, examples are provided on the use of UPLC-MS for finding lipid biomarkers in disease, drug, food, nutrition and plant fields. We also discuss the UPLC-MS-based lipidomics for the future perspectives and their potential problems. PMID: 25014415 [PubMed - as supplied by publisher]
Publication date: Available online 5 July 2020Source: Journal of the American College of RadiologyAuthor(s): Eric John Lopez
Publication date: Available online 5 July 2020Source: Journal of the American College of RadiologyAuthor(s): Sunyoung Lee, Yeun-Yoon Kim, Jaeseung Shin, Shin Hye Hwang, Yun Ho Roh, Yong Eun Chung, Jin-Young Choi
A nonprofit organization assessed almost 3,300 hospitals nationwide on 42 metrics. Its new methodology recognized civic leadership, value of care and quality of care as central components of the ranking.
By Matthew Warren As the reality of the coronavirus pandemic set in in March, we looked at the work of psychologists attempting to understand how the crisis is affecting us, and to inform our response to it. A few months later, and hundreds of studies have been conducted or are in progress, examining everything from the spread of conspiracy theories to the characteristics that make people more likely to obey lockdown measures. However, some researchers have raised alarm. They’re worried that many of these rapid new studies are falling prey to methodological issues which could lead to false results and misleading...
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