In Process Citation.

[In Process Citation]. Anasthesiol Intensivmed Notfallmed Schmerzther. 2014 Jun;49(6):388-95 Authors: Görtler M, Oldag A, Brejova A Abstract Management of ischemic stroke is targeted on four therapeutic objectives: limitation of neurological deficit, prevention of earyl stroke recurrence, protection against complications, and secondary prevention. Intravenous thrombolysis within 4.5h of stroke onset is the only proven therapy to improvefunctional outcome. Although promising, neither endovascular recanalisation nor neuroprotective strategies have demonstrated efficacy so far. Immediate administration of antiplatelet agents like acetylsalicylic acid and clopidogrel - in case of intravenous thrombolysis at the earliest after 24h - is effective to prevent early stroke recurrence, whereas anticoagulants should be ommitted in this stage because of an increased risk of cerebral hemorrhage. Subcutaneous heparin/low molecular weight heparin, mobilisation, nasogastric tube, and decompressive craniectomy may protect from venous thromboembolism, aspiration pneumonia, and malignant brain edema, respectively. Secondary prevention is guided by stroke etiology, e.g. oral anticoagulation in the presence atrial fibrillation or endarterectomy in case of sympomatic high-grade carotid stenosis. PMID: 25007216 [PubMed - in process]
Source: Anasthesiologie, Intensivmedizin, Notfallmedizin, Schmerztherapie : AINS - Category: Intensive Care Authors: Tags: Anasthesiol Intensivmed Notfallmed Schmerzther Source Type: research

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Authors: Sarda C, Fazal F, Rello J Abstract Introduction: Treatment of ventilator-associated pneumonia (VAP) is a major challenge. The increase in multi-drug resistant bacteria has not been accompanied by the validation of new drugs, or by any new antimicrobial strategies to exploit the available agents. VAP due to Gram-negative bacteria has increased mortality, both due to the resistant pathogens themselves and due to inappropriate treatment. Local epidemiology, patients' characteristics and clinical responses provide the most important information for therapeutic decision-making. Moreover, data on VAP therapy due...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Publication date: Available online 18 June 2019Source: Journal of PhysiotherapyAuthor(s): Davide G de Sousa, Lisa A Harvey, Simone Dorsch, Bronwyn Varettas, Serena Jamieson, Abby Murphy, Sarah GiaccariAbstractQuestionDoes intensive sit-to-stand training in addition to usual care improve sit-to-stand ability in people who are unable to stand up independently after stroke?DesignA multi-centre randomised controlled trial with concealed allocation, assessor blinding and intention-to-treat analysis.ParticipantsThirty patients from two Sydney hospitals,
Source: Journal of Physiotherapy - Category: Physiotherapy Source Type: research
ConclusionAcute organophosphate poisoning treated with atropine showed a potential for inducing prothrombotic coagulation abnormalities, presented with PT. This life-threatening complication may additionally contribute to prolonged morbidity and mortality in OP poisonings, especially in patients with medical history of comorbidites.
Source: Toxicology Reports - Category: Toxicology Source Type: research
The role of the terminal complement pathway as the cause of atypical hemolytic uremic syndrome (aHUS) is widely recognized, but the relative contribution of the effectors C5a/C5aR1 and C5b-9 to disease pathogenesis has not been defined. Using FHR/R mice carrying a factor H mutation that causes cell surface complement alternative pathway dysregulation, Ueda documented that in FHR/R mice, C5b-9 causes renal thrombotic microangiopathy (TMA) whereas C5a/C5aR drives macrovascular thrombosis. This commentary addresses the implications and limitations of this study.
Source: Kidney International - Category: Urology & Nephrology Authors: Tags: Commentary Source Type: research
Mortality from inflammatory bowel disease (IBD) is rare and even rarer in paediatric patients. Usually when we consider causes of death in patients with IBD, cancer, venous thromboembolism, sepsis and nutrition are at the front of mind. However, the pop...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Adolescents Source Type: news
Temperature increases due to climate changes and operations expected to be conducted in hot environments make heat-related injuries a major medical concern for the military. The most serious of heat-related injuries is exertional heat stroke (EHS). EHS gen...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Environmental Issues, Climate, Geophysics Source Type: news
OBJECTIVE: Explore the association between demographic factors and functional performance measures of patients with acute stroke in an inpatient rehabilitation facility (IRF) and falls during the IRF stay, and to quantify the diagnostic accuracy of functio...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Ergonomics, Human Factors, Anthropometrics, Physiology Source Type: news
Publication date: Available online 18 June 2019Source: Respiratory Medicine Case ReportsAuthor(s): Ryota Shintani, Tsuneyuki Oda, Takashi Niwa, Akimasa Sekine, Eri Hagiwara, Koji Okudela, Tamiko Takemura, Takashi OguraAbstractA 53-year-old Japanese female was admitted to our hospital with 3-week history of cough and worsening dyspnea. Chest computed tomography revealed unilateral focal consolidation in the right lower lobe. She underwent transbronchial lung cryobiopsy (TBLC) and histology showed acute fibrinous and organizing pneumonia (AFOP). High-dose methylprednisolone treatment improved her respiratory condition and ra...
Source: Respiratory Medicine Case Reports - Category: Respiratory Medicine Source Type: research
We present a novel method that extends current CLSM approaches by introducing a fast reliable and accurate way for computing disconnectomes, i.e. identifying damaged or lesioned connections. We introduce a new algorithm that finds the maximally disconnected subgraph containing regions and region pairs with the greatest shared connectivity loss. After normalizing a stroke patient's segmented MRI lesion into template space, probability weighted structural connectivity matrices are constructed from shortest paths found in white matter voxel graphs of 210 subjects from the Human Connectome Project. Percent connectivity loss ma...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
Conditions:   Pusher Syndrome;   Subacute Stroke Interventions:   Other: Visual Feedback and Core Stability exercises protocol;   Other: Control stroke Sponsors:   Parc Sanitari Pere Virgili;   Universitat Internacional de Catalunya Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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