Viral (HCV, HBV, HIV) Persistence and Immune Homeostasis.

This article is protected by copyright. All rights reserved. PMID: 24965611 [PubMed - as supplied by publisher]
Source: Immunology - Category: Allergy & Immunology Authors: Tags: Immunology Source Type: research

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We report a rare case of HBV reactivation in a patient with HCV infection after DAA therapy. Patient concerns: In 1996, a 53-year-old female was identified as infected with HCV at a medical check-up, following which she visited our hospital. She was infected with HCV genotype 2b, and at follow up in 1997, was found to be hepatitis B surface antigen (HBsAg) and antibody against HBsAg negative, antibody against HBV core positive. She then experienced malignant lymphoma in 2001 at 58 years of age. Complete remission was achieved following chemotherapy and autologous peripheral blood stem cell transplantation. In 2014, she ...
Source: Medicine - Category: Internal Medicine Tags: Research Article: Clinical Case Report Source Type: research
This article aims to estimate the cost-effectiveness of scaling up these interventions by scenarios, regions, and income groups.
Source: Value in Health - Category: International Medicine & Public Health Authors: Source Type: research
Medgadget would like to congratulate Harvey J. Alter, Michael Houghton, and Charles M. Rice on receiving the Nobel Prize in Physiology or Medicine for their work in discovering the hepatitis C virus. Hepatitis C, a virus that infects liver cells ...
Source: Medgadget - Category: Medical Devices Authors: Tags: Genetics Medicine News Source Type: blogs
(STOCKHOLM) — Americans Harvey J. Alter and Charles M. Rice and British-born scientist Michael Houghton won the Nobel Prize for medicine on Monday for their discovery of the hepatitis C virus, a major source of liver disease that affects millions worldwide. Announcing the prize in Stockholm, the Nobel Committee noted that the trio’s work identified a major source of blood-borne hepatitis that couldn’t be explained by the previously discovered hepatitis A and B viruses. Their work, dating back to the 1970s and 1980s, has helped saved millions of lives, the committee said. “Thanks to their discovery, ...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized News News Desk wire Source Type: news
Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
IntroductionResidual immune dysfunctions, resembling those that occur during normal aging, may persist even in well-treated people with HIV (PWH), and accelerated aging has been proposed. We aimed to determine if HIV infection is an independent risk factor for T-cell immune dysfunctions including increased immune activation, senescence and apoptosis. Moreover, in PWH we aimed to identify the associations between age and immune activation, senescence and apoptosis.Materials and MethodsWe included 780 PWH with suppressed viral replication (
Source: Frontiers in Immunology - Category: Allergy & Immunology Source Type: research
Two-year-old Aligos Therapeutics Inc. is seeking a $100 million initial public offering to help take its experimental chronic hepatitis B drugs into clinical trials. The South San Francisco company is the work of much of the executive team that translated $74 million in investments for hepatitis C-focused Alios BioPharma Inc. of South San Francisco into a $1.75 billion cash deal in 2014 with Johnson&Johnson's (NYSE: JNJ) Janssen Pharmaceutical unit. Janssen ultimately dumped Alios' oral drug,…
Source: Health Care:Pharmaceuticals headlines - Category: Pharmaceuticals Authors: Source Type: news
Abstract BACKGROUND: Accidental occupational injuries increase the risk of communicable diseases like hepatitis B virus (HBV), hepatitis C virus (HCV), and human immunodeficiency virus (HIV) among dental personnel. Such occupational injuries affect healthcare quality by enhancing dissatisfaction and lack of motivation to work among dental personnel. OBJECTIVE: The present study aims to assess knowledge and awareness regarding needle stick and sharp injury among dental personnel and compared the knowledge and awareness level about needle stick injuries between dental professionals and dental supporting staff w...
Source: Work - Category: Occupational Health Authors: Tags: Work Source Type: research
AbstractPattern recognition receptors (PRRs) are a pivotal part of the immune system. They are distributed in almost every site of higher organisms, able to recognize foreign pathogens or unwanted remnants of metabolism and mount innate immune response. Moreover, PRRs create bridging signaling to initiate adaptive immunity. The liver being the largest organ of the body, exposed to myriads of foreign substances often being immunogenic, is well equipped with PRRs. They act as sentinels of the organ, both in health and disease. In viral hepatitis C at least two of them, RIG-1 and TLR3 sense HCV, induce protective interferon p...
Source: Archivum Immunologiae et Therapiae Experimentalis - Category: Allergy & Immunology Source Type: research
F, Rizzo LV Abstract BACKGROUND: Coronavirus disease 2019 (COVID-19) convalescent plasma (CCP) collection began in two Brazilian hospitals for treatment of severe/critical patients. METHODS AND MATERIALS: Mild/moderate COVID-19 convalescents were selected as CCP donors after reverse transcription polymerase chain reaction (RT-PCR) confirmed severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and absence of symptoms for ≥14 days plus (a) age (18-60 years), body weight greater than 55 kg; (b) immunohematological studies; (c) no infectious markers of hepatitis B virus, ...
Source: Transfusion - Category: Hematology Authors: Tags: Transfusion Source Type: research
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